Bone and joints tuberculosis is a secondary infection of locomotor system, caused by a Mycobacterium Tuberculo- sis. Low incidence of tuberculosis has been maintained for a long period of time due to use of efficient chemotherapy. Howe- ver, in recent years increasing number of newly registered cases is seen, due to wide use of immunosuppressive therapy, spread of HIV, aging population. Those factors influence mycobacterium more likely to become drug resistant. The objecti- ve of the study is to review epidemiological, clinical,radiology and laboratory findings of bone and joints tuberculosis in our patients, and treatment efficiency. In 15 years of prospective study, 107 different ages male and female adult patients, were treated. In most cases spinal tuberculosis was registered (24%), then hip tuberculosis (17%), knee tuberculosis (16%) and tu- berculosis of sacroiliac joint (7%). Non operative treatment with antitubercular drugs was performed in all patients, while in 41% we used operative treatment. Early diagnosis of bone and joints tuberculosis, while treated with non operative (anti tu- berculosis drugs) and operative methods are preconditions to achieve high percentages of long term remission.

Aging as continous biological process, affect all organic systems. Aging is believed to affect the structure and function of the enteric nervous system. Prymary aim these studies is to verify changes in number of neurons in myenteric nervous plexus of human stomach within relation to process of aging. In the course of research played is analysis number of neurons in myenteric nervous plexus of anterior wall stomach. Analysis was performed within 30 tissue samples which are classified into three age groups: (from 20 to 44 years, from 45 to 64 years and over 65 to 84 year old). Played is histological processing and stained with HE, Cresyl-violet, AgNO3 and AChE methods. The morphometric measures operated by morphometric multipurpose test system M42. Finding results are statistically processed by Student-t-test and analysis of variance. Discernible is very heavy loss of neurons of myenteric plexus within the oldest group in relation to younger groups. Applied test show are having statistically notable variance between age groups. In percentage, the loss of neurons in the oldest group in relation to others was from 13,81% to 15,44%.

Copper is an essential element, a constituent of all living cells and an integral component of many enzymes. The increase in pollution of the environment, and various metabolic diseases, imbalances biological processes and homeostatic regulated content of bioelements in the body. For the purpose of determining changes in the contents of bioelements with increased intake of copper, the paper followed by interaction before and after ingestion of copper. The results showed that copper in excess causes disruption of physiological interactions of bioelements in tissues and significantly increases the content of iron and magnesium. The nature and relationships of these interactions are important, because in terms of exposure to metals, there are changes in their mutual relations, with some of these antagonistic relationships may be utilized for further study in order to protect them from toxicity.

Rheumatoid arthritis is a chronic multisistemic disease of an unknown cause characterised by persistens inflammatory synovitis which results in destruction cartilage and bone erosions. RA is a systemic disease with various out of joint manifestations of different clinical importance, among which rheumatoid knots, rheumatoid vasculitis, pleuropulmonal and ophthalmological manifestations are the most prominent ones. The most frequent changes of the eye in patients with RA are keratoconjunctivitis sicca (KCS), episcleritis and scleritis and ulcerous keratitis. Out of 70 examined patients, 52 (74.3%) are female, and 18 (25.7%) of male sex (ratio 4:1), average age 56.47. In 18 (25.71%) RA diseased patients eye changes found are as folows: secondary Sjögren syndrom, that is keratoconjunctvitis sicca in 18.57%, only in female patients, episcleritis nodosa and scleritis in 4.29%; 2.86% in male and 1.43% female patients and ulcerous keratitis in 2.86% RA diseased patients. 

In our work we analyzed utilisation of antibiotics for systemic use at the Surgical Clinic of the Clinical Hospital Centre - Pristina in Gracanica in 2007. and 2008. Data on antibiotic utilization were delivered on the basis of drug dispensing records from the Central Hospital Pharmacy during the two-years period. Antibiotics were distributed inside the ATC/DDD system in accordance with WHO guidelines. Quantitative antibiotics' utilisation was expressed as number of defined daily doses per 100 patient-days (DDDs/100 PD). Overall use of antibiotics in 2007 was 123.37 DDDs/100 PD, and 125.09 DDDs /100 PD in 2008. Three most utilized antibiotics in 2007. were cefuroxime 24.26 DDDs/100 PD (19.66 % of total antibiotics' use), ceftriaxone 16.65 DDDs/100 PD (13.49 %), and cephalexin 15.78 DDDs/100 PD (12.79 %). In 2008. the most utilized were ceftriaxone 23.23 DDDs/100 PD (18.57 %), cefuroxime 22.53 DDDs/100 PD (18.01 %), and co-trimoxazole 19,55 DDDs/100 PD (15.63 %). Qualitative and quantitative part of the consumed antibiotics was mainly in accordance with the results of similar researches in our country.

The two most common types of skin cancer are basal cell and squamous cell carcinoma, well known as nonmelanoma skin cancers. These cancers are the most common malignant tumors in white population and its incidence is increasing
dramatically. Information about the time of occurrence and cancer growth rate is a significant segment in establishing the primary skin cancer diagnosis. The aim of this prospective study is to determine the correlation between the size of basocellular and squamous cell carcinoma, represented through the function of cancer diameter and time period elapsed from their occurrence up to the surgical intervention. Apart from general anamnestic data, it was also insisted on as precise as possible datum referring to the cancer occurrence time. All cancers have been hystopathologically confirmed. Linear regressive analysis was used for establishing the interdependence between the diameters of tumors and their duration. The average growth of basocellular carcinoma in our patients was 4.3 mm on annual basis, i.e. 6.1 mm annually for squamous cell carcinoma. Tumor duration is a significant anamnestic datum for establishing diagnosis which can indicate a biological aggressiveness or skin cancer type. 

Diabetic retinopathy is the microangiopathy which procedures pre capillary arterioles, capillaries and post capillary venules. The length of disease and poor metabolic control, have the biggest impact on development and progression of DR. By the prospective study in Gracanica Health House, for the period time of six months, there were matched 50 patients with DM tip 2.Along of internal review, there were made ophthalmological review, and anthropometric and laboratory researches.

Even 1000 years BC the famous Persian physician Aviccena describet the first time gangrene diabetes mellitus as a complication. Basic pathohistological substrate vascular complication is atherosclerotic plaqueand therefore is an adequate treatment opf patients with vascular disease is conditioned by timely and precise diagnosis.The introduction of ultrasound technology in clinical practice enabled Edler and Hertz when the shou moves infarction 1954th,a then and Yoshida (1956.) and Sotomura (1959.), Frenklin (1961.) who are using ultrasound display of blood flow in the courts of man. The aim of our study was to deterimne the frequency of occurrences of atherosclerotic plaque in the carotid arteries and ultrasound examination of differences in the variability of certain plaques between patients with diabetes mellitus type 2 and healthy subjects. The examination was attended by a total of 82 people divided into two group. In first group they are 51 persons suffering from diabetes mellitus type 2 in to second control, the number of healthy respondents was 31. Among our respondents, a significantly higher incidence and plaque vulnerability was ina group of patients with diabetes mellitus type 2. 

In diabetics fungal skin infections are reported to be related to greatly disturbed metabolism. In order to get better insight into the association between diabetes mellitus and fungal skin infections, we started our study with the aim to assess the effect of metabolic regulation on the incidence of fungal skin infections is diabetics. The obtained results of our study show that in patient with metabolically poorly regulated primary disease i.e. diabetes the incidence of the fungal skin infections is highest (36.0%), its incidence is lower in patients with metabolically satisfactorily regulated diabetes (29.5%) and lowest in those with well regulated diabetes (18.8%), witch is statistically significant difference (p=0.045).

Endometrial hyperplasia appears like a result of continues, not mortified stimulation of endometrial by estrogenically hormones. Endometrial becomes nub which histological mirrors in endometrial gland multiplication, in smaller amount even endometrial strom. Endometrial polyp represents focal overmuch growth of gland stromas endometrial and its considered a focal endometrial hyperplasia. Therefore we will examine them at the same time. Medical faculty of Prishtina - Kosovska Mitrovica did an analysis of biopsy and operational material in pathology institute in the period from 2005 to 2008 out of 3696 histological proved cases, its recorded that 210 cases have endometrial hyperplasia and endometrial polyp, which is 5,68%. According histological type the most often seen is endometrii hyperplasia simplex who is spotted in 127 cases (60,48% - D= 0,195; p<0,001), endometrii hyperplasia complex in 19 cases (9,09%), cases where endometrial hyper-plasia and endometrial polyps are united are spotted in 14 cases (6,67%), while endometrii polypus in 50 cases (23,81%). By analysis of all types of endometrial hyperplasia and endometrial polyps we came to conclusion that all of these changes are mostly made at the age of 41-50 (60,48%) compared to other ages. (D=0,267; p<0,001). In between all patients the youngest was 22 years old (endometrii hyperplasia simplex) and the oldest 78 years old (endometrii polypus). On the basics of studied values, regression's analysis it's been confirmed that the numbers of cases with endometrial hyperplasia and endometrial polyps are growing for 8,6 every year, which points at bigger and bigger problem in the whole pathology.