Diabetes mellitus is one of the most common non-communicable chronic diseases, which is the combined action of genetic factors, environmental factors and lifestyle. Specific conditions occur in the oral cavity in the course of diabetes that cause changes in all oral tissues with different symptoms and signs. Increased salivary glucose level is followed by increased accumulation of dental plaque and decreased resistance to noxious agents. The most common oral manifestations in diabetic patients include higher prevalence of periodontal desease, burning mouth syndrome, disruption in salivary flow, opportunistic infections, higher prevalence of denture stomatitis, oral lichen planus, fissured tongue, angular cheilitis etc. Dental interventions in patients with well-controlled diabetes are not different from those applied to nondiabetic patients. Regular monitoring of these patients is required because of the complications that can occur.

One of the best-studied responses of cognitive evoked potentials is a so-called “P300”, the late positive wave complex that occurs about 300-500 ms after the stimulus. It is obtained when the subject’s attention is focused on a signal that is rare, especially if the signal has a motivational or emotional meaning. In the study of P300 potential, we followed the variations of potential amplitude and latency, so the objective was to examine whether there is a difference in Fz and Cz amplitudes of auditory induced cognitive evoked P300 potential depending on the performance of oddball tasks, both in male and female subjects. The study included 60 subjects (30 female respondents and 30 male respondents). P300 potential is induced by the auditory "oddball" paradigm with 80% of non-target and 20% of target stimuli that are presented to the patient through headphones. The target tones are high tones of 2000 Hz. The standard, 1000 Hz tones the respondent should ignore but when he hears the target tones the respondent should press the button on the special handle. The value of Fz and Cz amplitudes both in male and female subjects obtained in the classical "oddball" paradigm when the subject reacted to the signal by pressing the key with the dominant (right) arm were statistically significantly lower (p>0,05) than the values of Fz and Cz amplitudes obtained when the key was pressed by the non-dominant hand. Based on this experiment it can be concluded that both in male and female subjects the performance of oddball tasks does not affect the amplitude of P300 cognitive evoked potentials.

Najčešći maligni tumori kože epidermoidnog porekla su bazocelularni (BCK) i skvamocelularni (SCK) karcinom. U 90 % slučajeva nastaju na fotoeksponiranim delovima tela i direktno su povezani sa oštećenjima kože nastalim dugotrajnim izlaganjem UV zracima, obično kod osoba starijeg životnog doba i svetle puti. Od njihovih posledica godišnje u svetu umre 65000 ljudi. Najvažnija karika u sprečavanju nastanka ovih tumora jeste prevencija, dok njihovo rano prepoznavanje omogućava adekvatniji hirurški tretman sa poštedom okolnog tkiva. Osnovni cilj ovog rada je ispitivanje histopatoloških i kliničko-morfoloških karakteristika BCK i SCK kože glave. Analizom je obuhvaćeno 439 karcinoma (297 (67,7%) BCK, 126 (28,7 %) SCK i 16 (3,6%) BCK+SCK), među kojima je preko 60% dijagnostikovano kod muškaraca, najčešće u sedmoj i osmoj deceniji života, sa najvećom učestalošću BCK na nosu, odnosno na koži gornje polovine kože lica i SCK na usnama, odnosno na koži donje polovine kože lica. Svi karcinomi kože glave bili su češći na desnoj strani. Klinički i morfološki, najveći broj BCK manifestovao se ulceroznim oblikom prosečne veličine 1,2cm i mešanim histološkim tipom, a SCK vegetantnim oblikom prosečne veličine 1,55cm i histološki gradusom I. Najveći broj BCK i SCK bio je odstranjen u celini, za razliku od kombinacije ova dva tumora u kojima je u većini slučajeva bila neophodna i naknadna hirurška intervencija.

Necrotizing otitis externa, also known as malignant type of the inflammatory process, represents an infection of the skin of external hearing canal, a fast development of tissue necrosis and infection spreading to the surrounding structures. Basic clinical characteristics are: strong earache, leaking from ear, granulation findings at the bottom of the hearing canal, the disorder of hearing function and a potential possibility of complications (paralysis of facial nerve, intracranial infections). Mycrobiologically the most present bacerium is Pseudomonas aeruginosa. Other microorganisms that can be isolated are Aspergillus species, Staphylococcus aureus, Proteus mirabilis, Klebsiella oxytoca, Candida parapsilosis. The disease is more common in patients with general diseases, mostly of metabolic nature (diabetes mellitus). The approach to diagnosis and therapy is usually urgent in order to prevent the development of serious complications. This paper shows the results of the analysis of clinical process of malignant otitis in 25 patients from the Clinic of ORL and MFS KCS according to the type of the cause and the development of potentially severe and life threatening complications.

During the armed conflict in Kosovo and Metohija, and after it, were killed more than 5 000 people, and according to the International Red Cross Committee in March 2001, 3,338 people were still missing. Until the conclusion of this study, the number of missing persons in Kosovo and Metohia for which the trail is about 1700. This list includes people from all ethnic communities. The primary objective of the forensic investigation is to determine the identity of the missing persons and after that their remains returne to the families, in accordance with Geneva protocols. Experts post-mortem examination after the exhumation determine the cause and manner of death, which indicates a violation of human rights and war crimes.Conclusion. We are facing with reasonable fear that with the passage of time, less interest will be devoted to this issue and the activities on finding and identifying missing persons will completely stop.

The most important characteristic of calcium channels is selective regulation of slow incoming stream of calcium into the cell tissue providing the slow increasement of action potential. Such tissues include smooth muscles of blood vessels, cardiocytes and heart noduses (AV and SA node). Different calcuim antagonists have different effects on previous tissues due to their different chemical formula. Verapamile, Nifedipin and Diltiazem are the most frequently used of all. Their commonest characteristic is blocking the calcium channels causing vasodilatation of blood vessels as well as negative inotropic and chronotropic influence. By blocking the incoming calcium through slow channels of myofibrils of smooth muscles, the antagonists of calcium decrease the quantity of available calcium for contraction which causes vasodilatation. The most famous and most frequently used calcium antagonist is Verapamile. In terms of electrophysiology, Verapamile inhibits action potentials of heart noduses, especially the AV node, where the slow incoming of calcium is the most important for depolarization. Prolongation of the efective refractory period of SA node causes the heart frequency decreasement while prolongation of the effective refractory period of AV node slows down the work of chambers in case of flater and fibrillation of atriums. The molecules of calcium-bonding protein called kalmodulin are located in synaptic endings. Each kalmodulin can bond four calcium ions providing transfer into active calcium-kalmodulin complex which activates the kinase protein. Activated kinase protein starts the exocytosis of neurotransmitters into synaptic gap. Apart from activating kinase protein, calciumkalmodulin complex also starts the activity of calcium pump presynaptic membrane which pumps calcium out of presynaptic ending stopping the further exocytosis of neurotransmitters into synaptic gap. Taking into consideration the fact that opening the calcium channels on membrane of presynaptic ending is necessary to free the neurotransmitter out of the vesicle, the aim of our work is to study whether Verapamile has effects on the membrane of presynaptic endings of sympathetic nervous system checking the level of catecholamine in serum. The experiment was conducted in 6 healthy dogs which were, after 10-minute- infusion (0.9% NaCl), treated with intravenous bolus veramapile injections in three occasions, in every 5 minutes, until the first signs of intoxication had appeared. This caused bradycardia, heart rhythm disorder and blood pressure drop. In order to determine the level of catecholamine, blood was taken sequentially, in every 5 minutes, before the new dose of verapamile was given. Verapamile (given intravenous) significantly decreases the concentration of adrenaline and noradrenaline in the serum of dogs.

The mos Tooth whitening is a procedure that removes stains and various discolorations of tooth surface. Discoloration of teeth may be endogenous and exogenous nature. The aim of this study was to investigate the impact of bleaching combined with daily use of drinks that cause tooth discoloration. Evaluated the changes in surface structure of enamel, and changes in hardness after bleaching. Were 20 extracted teeth. The teeth are marked with longitudinal lines halves (medial vestibular and distal surfaces). Tretitana mesial half of the 16% carbamide peroxide, a distal was left as control. NDT device HL400DL, duroskopskom method of enamel hardness was measured before treatment, after treatment and after remineralization. Olympus inverted microscope GX41 enamel structures were observed in the treated and control half of the tooth. After bleaching there is a difference compared to the untreated surface, that surface is bleached a few shades lighter, but after the use of coffee and soft drinks teeth back to the original dark color. Enamel microhardness after the treatment is somewhat small but not significant. With a magnification of 2000x and see the structural changes in enamel. Tooth whitening, but that the remineralization and the abstinence from prebojenih beverages and tobacco.

Human preterm labor is a syndrome that may arise from different causes. Before 30 weeks of gestation, infection appears to predominate amongst these. In later gestation, premature activation of the fetal HPA axis in response to an adverse intrauterine environment, e.g. hypoxemia, undernutrition (UN) or even infection, may underlie the stimulus to prematurity. A third pathway clearly involves vascular thrombotic processes. Tests on sheep have been shown to there is a premature birth which is a significant change was associated with precocious increases in adrenocorticotrophic hormone (ACTH) and cortisol in the fetal circulation, and increased levels of mRNA encoding proopiomelanocortin (POMC) and prohormone convertase-1 (PC-1) in the pars intermedia of the fetal pituitary. It would seem that these different pathways may occur separately, or be activated to different degrees in the same patient.

Pokušaj samoubistva predstavlja aktivnosti koje imaju za cilj oduzimanje sopstvenog života, a koje ne završavaju smrću. Odnos pokušanih i realizovanih samoubistava izražen je tzv. Indeksom opasnosti (Hazard ratio). Faktori rizika koji podstiču samoubilačko ponašanje su: različita emocionalna stanja, crte ličnosti, stresogeni životni događaji, zloupotreba psihoaktivnih supstanci itd. Cilj rada: prikazati učestalost i epidemiološko demografske karakteristike pokušanih samoubistava kod žena i muškaraca. Urađeno je istraživanje na uzorku od 56 pacijenata kod kojih je postavljena dijagnoza pokušaja samoubistva (Tentamen suicidii), na psihijatrijskom odeljenju KBC Priština, Gračanica. Uzorak je analiziran na osnovu pola, starosne dobi, zanimanja/zaposlenosti, psihijatrijske dijagnoze, motiva i načina pokušaja samoubistva. Rezultati: samoubistvo su pokušale 42 žene (75%) i 14 muškaraca (25%). Najveći broj ispitanika (26.8) u našem istraživanju su iz starosne dobi <20 godina. Najzastupljeniji su nezaposleni, 33,3% žena i 50% muškaraca. Najčešća dijagnoza su anksiozni poremećaji, 61,9% žena i 57,1% muškaraca. Najčešći motiv kod žena je patrnerski konflikt 54,8%, kod muškaraca egzistencijalna ugroženost 50%. Od 56 pacijenata njih 51 (91,1%) je pokušalo samoubistvo trovanjem i to anksioliticima. Znatno veći broj pokušaja samoubistva (75%) desio se u popodnevnim i vešernjim časovima, u periodu od 12 do 24h. Zaključak: žene su češće pokušavale samoubistvo u odnosu na muškarce, odnos 3:1. Najčešće nezaposleni kod oba pola ispitanika, najčešća dijagnoza, anksiozni poremećaji. Najzastupljeniji motiv kod žena je partnerski konflikt, kod muškaraca egzistencijalna ugroženost. Kod oba pola ispitanika najčešći način pokušaja samoubistva je trovanje, najčešće u periodu od 12 do 24h.

Post-streptococcal glomerulonephritis (PSGN) is a frequent cause of acute nephritis in children. This case study was done with the aim to point out that the infections caused by Group A streptococci, in spite of antibiotic era, are still present in the population. An 8-year old boy was admitted in our hospital with a two-day history of fewer, tonsillopharyngitis. After hospital admission, patient was treated with penicillin during the period of 10 days, antihypertensive medications (captopril, furosemide), including restricted diet of salt. After the treatment, patient became better. On demission it was found proteinuria and microhematuriaPSGN is very serious disease, which leaves severe complications if the valid therapy with penicillin is not used in propriety time, during the recommended period of 10 days.