The complexity of the open bite is attributed to the combination of the skeletal, dental and soft tissue elements. Depending on the etiology there are different approaches in their solution from conventional to surgical orthodontic treatment. In boys, aged 15 years, was found anterior open bite. After diagnostic procedures and growth assessment, the Demon nonsurgical orthodontic treatment technique was performed. The use of mild force, low friction and early use of intraoral elastics, arterior vertikal and class II in the area of the side teeth, have enabled us to take advantage of favorable growth type maxillofacial complex by which we have achieved a satisfactory therapeutic effect and close the open bite.

Basal cell carcinoma is a slow-growing malignant skin tumor and its often found in elderly patients on sun exposed areas that confirming chronic UV radiation. Demographic, clinical and histological characteristics of the patients have been analyzed of nodular type of basal cell carcinoma in order to determine correlation between localization, duration and tumor size. Database was searched for medical records of patients with nodular BCC evaluated in Health Center of Kosovska Mitrovica and Clinical Center of Nis during the period of 2006 through 2008 year with the focus on demographic characteristics, localization, duration, size and clinical and histological characteristics of the tumor. Results: 36 patients with nodular BCC, 14 female and 22 male, in average old between 72.5±7.26 years of age. Two thirds of patients is older than 60 years and only 3 (8.33%) male patients are younger than 60 years of age. 72.11% of patients living in rural areas unlike 27.77% that lives in urban areas. Nodular type is occurring more often in males on skin of frontal and zygomatical region and in females on zygomatic and nose region. We found that the size of the tumor is in close correlation with length of duration of illness. Nodal BCC is more common in elderly male patients. Nodular type is occurring more often in males on skin of frontal and zygomatical region with a different distribution among women.

Frequent occurrence of dental caries and periodontal diseases, especially gingivitis, in school-aged children, is becoming one of the most important problems in oral pathology, although they all can be brought under control through health education and implementation of preventive and prophylactic measures. The aim of this study was to determine the incidence of dental caries and gingivitis in children, aged 12 years, attending primary schools in Kosovska Mitrovica, as an urban area, and schools in Gračanica and Laplje Selo, as rural areas. The study included 227 schoolchildren, aged 12 years, divided into two groups. One group, 129 of them, consisted of children from primary schools in Kosovska Mitrovica, as urban areas. The other group, 98 of them, consisted of children from primary schools in Gračanica and Laplje Selo, as rural areas. Klein-Palmer DMFT system (D-Decayed, M-Missing, F-filled) was used to estimate the prevalence of dental caries, while Silness-Löe plaque index, Löe-Silness gingival index and Muhlemann sulcus bleeding index were used to estimate the level of oral hygiene, gingival status and severity of gingival inflammation. The average number of permanent teeth with caries per respondent (DMFT) was 4.6 in total, for all children. The average value of DMFT in children from urban areas was 3.8, and 5.3 in children from rural areas. SiC Index was 7.9. The average value of the plaque index (PI) was 1.53±0.61, of the gingival index (GI)1.05±0.58 and of the bleeding index (BI) 0.64±0.59. The established state of oral health and periodontium in examined children points to the necessity of applying modern preventive and prophylactic measures in order to improve the oral health and increase the motivation for the overall health care.

A cardiovascular comorbidity (CVC) in psychiatric patients represents a simultaneous occurrence of a cardiovascular and a mental illness in the same patient regardless of the order of occurrence or of the cause and effect relationship that conjoins them. The objective was to determine the frequency and sort of the CVC in previously hospitalized patients with diagnoses of schizophrenic and affective disorders along with the differences in distribution of said disorders between the two groups of patients. Design-wise this is a retrospective study of intersections. It is based on the analytics of medical data (the history of disease along with the internal medicine consultant reviews) of the hospitalized patients in the Clinic for psychiatric disorders “Dr. Laza Lazarević” in Belgrade during the period between November 2014 and February 2015. Patients who were involved were older than 18 and they had diagnoses of schizophrenic disorders (F20-F29) and affective disorders (F30-F39), according to diagnostic criteria in the International classification of diseases 10 (ICD-10). CVC which were previously diagnosed or registered during the examination we separated into the following groups according to ICD-10: hypertension (HTA) I10, cardiac arrhythmia (CA) I47-I49, chronic cardiomyopathy (CMP) I42-I43 and ischemic heart disease (IHD) 120-125. The two groups of patients were analyzed according with socio-demographic characteristics (gender and age range) and CVC diagnosed according to MKB-10 classification. CVC were registered in 66% of the patients diagnosed with schizophrenia and 34% of the patients with affective disorders. Hypertension was most common in both groups of patients following with cardiac arrhythmia. Cardiac arrhythmias were statistically significantly more common in patients diagnosed with schizophrenic disorders (p<0.001) compared to patients with affective disorders. The frequency of hypertension, ischemic heart disease and chronic cardiomyopathy rises with age in both groups of patients. The results of this research confirm a high degree of CVC in hospitalized patients with diagnoses of schizophrenic and affective disorders (especially cardiac arrhythmia and hypertension). A multidisciplinary team is the key for diagnosing and monitoring patients with schizophrenic and affective diseases in both primary and secondary preventions.

Endocardial endothelium (EE) is a barrier which controls the passage of macromolecules and fluids between the blood and the adjacent miocardial interstitium. At the same time it is the place of synthesis of numerous endothelial mediators. Histamine as an inflammation mediator increases the permeability of the endothelium, but also has a positive inotropic and chronotropic effects on the heart through the activation of histamine H1 and H2 receptors. The aim of this study was to determine the importance of the role of endocardial endothelium in the effect of histamine on myocardial contraction in the conditions of histamine receptors blockade. The study was carried out on the samples of the right ventricle of the albino Wistar rats (n = 42, age 8 weeks, body mass 180-200g) presented in two experimental models. The first experimental model presented the right ventricle of the rat heart with an intact endocardial endothelium and the second with the endothelium chemically removed by immersion of the chamber in a 1% solution of Triton X-100. Histamine (1x10-4 mol/l) increases the contraction of the right ventricle of the heart with intact endocardial endothelium but also with the removed endocardial endothelium. The effect of the histamine on the contraction was significantly increased in the absence of endocardial endothelium (p<0.05). H1 receptor antagonist, pyrilamine (1x10-6 mol/l) significantly inhibites the positive inotropic effect of histamine on the heart in both groups, with or without endocardial endothelium. Modulatory role of endocardial endothelium in the effect of histamine after the receptors blockade by pyrilamine is not significant. H2 receptor antagonist, cimetidine (1x10-4 mol/l), blocks the positive inotropic effect of histamine on the heart reagardless of the preservation of the endocardial endothelium. Our results indicate the undoubted importance of the modulatory role of endocardial endothelial in the effect of histamine on myocardial contraction.

Hypertension represents one of the most significant preventable causes of death worldwide, and accordingly the target group for its prevention and early detection primarily refers to young population. Assessment of prevalence of selected risk factors for the development of hypertension among students, and determination of the existence of differences between genders, defined age groups and included faculties. A cross-sectional study was carried out during 2013., at Faculties of Medical Sciences, University of Belgrade. Respondents completed an questionnaire specially designed for the purpose of this study. Categorical data were analyzed using statistical chi-square test of independence. The study included 600 respondents, mainly female (61.2%), with the mean age of 53.1 ± 17.4 years. More than third of the participants (38,6%) reported the genetic predisposition to development of hypertension. Recorded modifiable risk factors were overweight (22,33%), regular extra salt intake (86,3%) and smoking (32,8%). The results of the study indicate presence of reversible risk factors in the observed population. Designing educational programs on chronic diseases during graduate studies is necessary to keep hypertension from developing at older age and mitigate the number of existing risk factors development.

Delivery before 37th week of gestation is defined as preterm, independently of body mass of babies, according to the World Health Organization. Premature birth is the current problem in the world due to the high risk of neonatal morbidity and mortality and incompletely clear etiology. In our country the frequency of preterm delivery is 6%. We have retrospectively analyzed early deliveries in Health Center Kosovska Mitrovica in the period from 2009 to 2013. In this five-year period, there were totaly 3398 deliveries, of which 148 or 4.35 % were preterm delivery. The aim of this study was to investigate the incidence of premature birth in the five-year period in relation to: the total number of births in a given period, the age of the patients, the manner of completion of delivery, gestational week of pregnancy, parity and the most common causes that led to the PTP. In the analysis we have included the body weight and Apgar score of premature infants. We have used protocols of births, maternal history of disease, neonatal protocols and lists of newborns. Most of them were multiparas (41.2 %),56.7 % of pregnant women were aged of 21-30 years and pregnancy in 79.9 % of cases ended with 33 to 37 ng. Vaginal deliveries were completed in 84.4% of premature births, and caesarean in 15.6%. Twin pregnancies with preterm deliveries were represented in 10.2%. The most common weight of premature infants ranged from 2000 to 2500 grams (48.6 %). The most common causes that led to the PTP were PPROM (22.9 %), unknown causes (27. 1 %), multiple pregnancy (18.2 %), genital infection (8.7 %), cervical incompetence (6.7 %), IUGR (5.4%), PIH (4.2%), placental abruption and placenta previa (2.1 %) and other (4.7%) .

Class II malocclusion are complex anomalies of the skeletal and dental systems. The aim of this study is that the rengenkefalometrics analysis closer determine the morphological characteristics of this malocclusion. For this study were used 30 patients aged 18-30, previously clinically diagnosed class II, before the planned orthodontic treatment. The results analisis lateral cephalometric radiographs were compared with the 30 patients with class I malocclusion. Analyzed three linear and two angular cranial base dimensions and nine angular and four linear measures from the facial skeleton. The Results show: No statistically significant differensis in cranial base angle (SNBa) and anterior cranial base length (S–N) between class II and control Class I. Angle maxillar prognathism ( SNA) is no signifikant different between class I and Class II but SNB angle were signifikant smaller. The length of maxillary base (A`-SnP) is longer and the length of mandibule (Pg`-MT1/MT) is signifficantly smaller. The gonial angle (ArGo–Me) was smaller with open articular angle (GoArSN). Morphological characteristics of class II malocclusion are , retrognathic and smaller mandibular ligth, normognathic and longer maxilla, open articular angle with vertical tendency of the craniofacial growth pattern.

Primary angle-closure glaucoma (PACG) is highly prevalent in Asian countries, compared with primary open-angle glaucoma (POAG), which is reported predominant disease among Whites and that is the reason for paucity of reports about central corneal thickness (CCT) and corneal curvature (CC) in eyes with PACG in Europe. To determine central corneal thickness, corneal curvature and refractive error in patients with primary angle-closure glaucoma (PACG) and primary open-angle glaucoma (POAG). A total of 288 patients were enrolled into this study; 132 patients with PACG (mean age of 73 ± 7 years) compared with 156 patients with POAG (mean age of 70 ±7 years). The data was collected from all PACG patients who underwent Laser peripheral iridotomy at the Clinic for Eye Diseases, Clinical Center of Serbia in Belgrade between January 2012 and October 2012 and controls with POAG examined in the same period. Data from the right eye was used for analysis. In PACG/POAG mean CCT was 549±38/547±35 µm (p=0.353) and mean radius of corneal curvature (Cr) was 7.92±0.22/7.75±0.29 mm (p=0.003). There was no statistically significant correlation between IOP and mean Cr in PACG (p=0.244 ) and POAG ( p=0.637) while it was in POAG group with refractive error (p=0.005) and CCT (p<0.001). We found that CCT in PACG and POAG group were in normal range and there was no diference between them. Our results showed that the eyes with PACG had the flatter corneas than eyes with POAG and were hyperopic.

Aging of population leads to limitations in functional abilities and in activities of daily living (ADL) which are the essential elements of independent care of oneself. Limitations in performing these activities result in increasing need for assistance and institutionalizing of the elderly. The aim of this study was to investigate the influence of fear of movement, or kinesiophobia, on ADL in elder institutionalized people with chronic pain. The research included 60 individuals older than 65 suffering from chronic musculoskeletal pain, institutionalized in Gerontoloski Centar Nis. The participants` fear of movement was assesed by Tampa Scale of Kinesiophobia, performing ADL was assesed by Katz index and pain intensity was evaluated by Numerical Rating Scale. We found that a large number of participants had high degree of kinesiophobia (63%), as well as that there is statistically significant negative correlation between the values of Katz index and Tampa Scale (r=-0.583, p<0.01). There is no statistically significant negative correlation between the values of Numerical Rating Scale and Katz index (r=0.139, p<0.289). There is no statistically significant positive correlation between the values of Numerical Rating Scale and Tampa Scale (r=0.215, p=0.098). The research showed that kinesiophobia has influence on ADL in elder institutionalized people with chronic pain. Higher degree of fear of movement corresponds to greater dependence of the participants in performing ADL. Pain intensity influenced neither the fear of movement nor the dependence/independence in performing ADL.