The aim of this study was to determine whether there is a correlation of latency and amplitude of P300 cognitive potential and the degree of lateralization of brain hemispheres. The study included 60 subjects whose age was between 45 and 56 years. Bioelectric brain activity was recorded using argentum chloride (AgCl) electrodes that were placed at central line of the scalp (over Fz and Cz regions) according to the international 10-20 standard. P300 was generated using “oddball” paradigm with randomized stimuli: A frequent 1000 Hz tone with an occurrence of 80 % and a 2000 Hz tone (target) with a 20 % occurrence. The measurement is done with the right hand (first recording) and left hand (second recording). All subjects in this study were tested for usage lateralization and showed that they are right-handed. Based on the results of gestural lateralization subjects are divided in three groups. In the group with high degree of lateralization latencies of P300 were significantly lower when dominant hand was used in comparison to non-dominant hand, on Fz electrode (t = 4,162, p<0,01) and Cz electrode (t = 5,302, p<0,01 (p<0.01) and amplitudes of P300 were significantly higher, on Fz electrode (t=-2,725, p<0,05), on Cz electrode (t=2,527, p<0,05). However, there were no statistically significant differences (p>0.05) for latencies and amplitudes of P300 between dominant and non-dominant hand for the group of subjects with weak and average degree of lateralization. In both subject groups, significantly faster RT was measured when dominant hand was used. The P300 cognitive potential and reaction time can contribute to the study of indicators of the functional hemispheric asymmetry of the brain.

Aging begins at the moment of birth and it is inevitable part of our lives. Statistical data obtained in recent years, indicate that the average human lifespan is significantly prolonged compared to the previous century, which is likely to come as a result of technological progress and consequently the development of medicine. Whole teams of scientists are constantly trying to clarify the process of aging and in some ways make it slower.Attempts to find the causes of aging is present for the purpose of extending the creative activity of man

It is known in the literature that the incidence and prevalence of suicide and attempted suicide in psychiatric patients is significantly higher than in the general population. The paper examined risk factors for suicidal behavior in the category of admitted patients hospitalized with the diagnosis of sleep disorders and affective (Unipolar resp. Bipolar depression). Study activated by 80 patients, 40 in both diagnostic groups received treatment at the Special Psychiatric Hospital in Gornja Toponica near Nis. The work methodology used are: psychiatric interview, Hamilton Depression Rating Scale (HAMD), and the C-SSRS (Columbia-Suicide Severity Rating Scale)- assessment tool that assesses suicidal ideation and behavior. The study results show that there is a relationship between suicidal behavior (suicide attempts and suicidal ideation) and the diagnosis of bipolar affective disorder, positive history of previous suicide attempts, so that these factors are stronger, to the degree of suicidality higher. On this sample, clearly suicidal behavior, with the same purpose, intensity of suicidal thoughts and medical impairment after suicide attempts were significantly more frequent in patients with Bipolar Affective Disorder in the depressive phase of the illness. Patients with a previous suicide attempt, and poor personal and social circumstances had a higher rate of attempted suicide.

Chronic kidney disease (CKD) is a syndrome which is caused by gradual progressive and irreversible reduction of kidney function. CKD has become a global health care problem. From a mental hygiene point of view, the aim of this study is to present the most important stressors in patients with CKD. Knowledge and recognition of everything that influences the increase of stress in people with CKD, on one hand leads to an improvement of understanding , and on the other gives us possibilities to prevent or at least reduce the negative effects of stress. Furthermore, patients with CKD often have anxiety and depressive symptoms which overlap with the clinical symptomatology of kidney disease, which is mostly caused by uremia. We have given certain suggestions for early depression screening in patients with CKD by analyzing previously conducted research. As far as diet is concerned, research suggests that patients with CKD should be prescribed a low protein diet which delays the progression of CKD, reduces the metabolical disbalance and delays the need for dialysis. A traditional diet focused on protein intake without a special selection of meals is recommended. Other recommendations are vegan diet as well as vegan diet with suplements. Furthermore, a diet without proteins with pastas without proteins, bread and other carbohydrates. There are also recommendations for a low protein diet with suplements with an intake of only 0.3 g/kg BM/protein a day with an addition of proteins from vegetables, amino and keto acids. Finally, it should be mentioned that comorbidities should be taken into consideration when prescribing a diet for patients with CKD. It is necessary for the patient to be compliant with the recommended diet.

Herpetic stomatitis as well as many other infections of the orofacial region in everyday practice represent an important percentage of pathology. These diseases can be a major problem for therapists in terms of early diagnosis and, consequently, in determining the correct treatment. The disease belongs to a group of droplet infection, caused by the herpes simplex virus, with characteristic changes in the skin and mucous membrane in children and adults. A relatively small percentage, 10-15% of primary infections are manifested with clinically distinct symptoms. At the oral mucosa occurs triad of symptoms: generalized catarrhal gingivitis, coated tongue and erosions dispersed all over oral epithelium of the oral cavity.

As a mixed exocrine and endocrine gland pancreas has a very important role in the digestive tract. The juice of his exocrine part, which is released into the duodenum, carries more than 20 pancreatic enzymes, important for a normal process of digestion. Endocrine part of the gland, which consists of the islets-insula, actively participate in the metabolism of human organism, secreting two important hormones - insulin and glucagon. Because of its location, the pancreas is an extremely inaccessible organ for a physical examination. Despite of a large number of modern clinical methods for monitoring changes in the body, the detail knowledge of morphological characteristics of this gland is still very important. The material was taken from the cadaver of the fetus and newborn at the Institute of Pathology of the Faculty of Medicine. We classified samples of pancreas into three groups, with respect to age (from 3 months to neonates) and CS length. After dehydration and the molding compositions are cut at a thickness of between 6 and 10 microns. In addition to standard staining methods, some preparations are for identification of insula, painted by Grimelijus. In this study, we determined the morphological changes of the prenatal pancreas, from the third month of intrauterine fetal development, until the end of the fetal time and determine the dynamics of changes in the parenchyma and stroma. We could distinguish functional parts of the pancreas, in 10-11th week of development. In the first trimester of pregnancy, we have noticed an increase in parenchymal elements and the reduction of the stroma, which is slightly more pronounced in interlobular area, that clearly differentiating lobules. At the beginning of the second trimester of pregnancy, in the pancreas that are developing, we observed significant changes.The lobular structure of pancreas was clearly visible. Pancreatic acini are clearly differentiated and are in very close contact, since the stroma between them very reduced. Within almost all lobulus there are clearly expressed the islets of Langerhans, which are multiplied, different sizes, separated from the exocrine part by poorly expressed connective tissue. In the group of prematurely born children, we found that the morphology of the pancreas is very similar to the pancreas at the end of the fetal period.

Anatomy of the female pelvic viscera was investigated before and after the Tension free Vaginal tape (TVT-O). Forty patients were included in the study. Surgery was performed between 2009 and 2012 in Clinic of Urology (Clinical Center Nis) and Department of Urology (Municipal Hospital Prokuplje). Stress Urinary Incontinence (SUI) and anterior vaginal wall prolapse was confirmed in all patients. In all patients with anterior vaginal wall prolapse (grade≥2) both tension free vaginal tape (TVT-O) and anterior vaginal wall repair were performed. Pelvic Organ Prolapse Quantification (POPQ) system was used for the evaluation of prolapse before and after the surgery. Mean age of patients was 61 years. Spinal anesthesia was performed in thirty patients and general anesthesia in 10 patients. Intraoperative blood loss was under 50 ml. There were no bladder, nerve and blood vessels injuries . Thirty eight out of forty patients (95%) were satisfied with the outcome of the surgery. There was a significant correction of prolapse after the surgery. Recurrence of prolapse was found in patients with the high grade prolapse before the surgery, as well as, in patients with the history of previous anterior vaginal repair. Pelvic organ prolapse, congenital or acquired, is supported by the congenital weakness of the pelvic floor.