Vitiligo manifests with hypopigmentated and depigmentated plates on the skin and mucous membranes. Etiopathogenic mechanism of disease appearing is not completely explained, though there are theories explaning the appearance of the disease. Precipitant factors, especially psyhotic stress, are very important for the appearance of the disease. The
patients usually come because of cosmetics defects, because vitiligo areas appear mostly on uncovered parts of a body. We
are presenting a girl, with the first sings of the disease appeared when she was seven, located symetrically periorbitally and
in capilicium followed by polyosis. The beginning of the disease might be connected with a psychotic stress.

The aim of the work is to study the development of twin pregnancy after one of twins died in early pregnancy and
possible negative influence on clotting system of pregnant women. Observation is done on patient DM, 30 years old, and
housewife. She was observed from her first appearance at the department. Personal and family anamnesis was regular. She
had one delivery tree years ago with Cesarean section. In the first ultrasonographic examination we found twin pregnancy
with obvious heartbeats of both twins. After two weeks on control examination we find only one fetus, regularly developed,
and in a separate amniotic cavity a fetus without heart beat with small quantity of amniotic fluid in bizarre position. Patient
was immediately admitted in the hospital. Ultrasonographic examination, as well as a routine laboratory analyses were
repeated every ten days. After 28-th week of gestation we included a cardiotocographic (CTG) control every five days. In
38-th week the birth was finished by cesarean section (indication for operation - previous cesarean section). Afemale child
was born. After delivery, placenta was extracted with membranes, which contained a dead fetus, 12-cm length. After
recovery which lasted seven days patient was dismissed in good condition with healthy baby. An ultrasound examination
proved to be of great help in putting a diagnosis. It is very important to put diagnosis in time, because if we don't do it, we
will probably have a great and heavy complication.

Hiposmia or anosmia are common cases after infections. The virus of influenza is most common cause of anosmia
and hiposmia. In a cause of hiposmia and anosmia which are the results of influenza it is need to start with regular and actual theraphy, or in other case anosmia or hiposmia are permanent.

Despite of Aspirin use in acute virus infection and reduce of incidence in many parts of the world, the Reye's syndrome is also actual in our country. Reye's syndrome was described for the first time in 1963. It's a non-inflammatory encephalopathy and lipid infiltration of liver and other organs. Etiology is unknown. Some viruses, some chemical compounds,
Aspirin and genetically abnormal answer have the role. The damage of mitochondria appears. Organism is in hard catabolism. The biochemical parameters in serum and liquor were followed at 26 children cured in treated in Pediatrics Clinic in Priština in the period from 1991-1998. The extreme hypoglycemia (<2.2 mmol/L) was in 46,1%, medium hypoglycemia
(2,3-3-,3 mmol/L) in 7,7%. Three times high transaminases appeared in 46% of children. The level of chaemostasis was reduced in 11,5% of children. Half of the total number children had the higher values of urea and creatinine. Hyperproteinorachia in liquor was 27% and hypoglycorachia was 19,3%. Metabolic acidosis was present in 61,5%. Half of the children had convulsions and pneumonia. Enterocolitis, acute renal insufficiency, anemy and urinary infection were also present.

In this work the authors have treated patient with a wide range of skin symptomes and a various clinical sings and
manifestations of this serious bullous skin disease. The complications such as secondary bacterial infections on eroded
areas and swallow difficulties, because mucous membrane of oral cavity was affected, have supplemantary disabled quick
and efficient therapy. Therapeutical problems were presented as weakness, exhaustion, obstruction syndrome and asthmatic
constitution of a patient. The high doses of corticosteroids could provoke a hypertension, but still, with gradually reduced
doses of corticosteroids, supported by local therapy with antibiotics and corticosteroids, we achieved rehabilitation and
healing of our patient

Spinal anesthesia is one of type of central block anesthesia. It is an anesthesia of choice for surgical procedure open prostatectomy. According to our experience this type of anaesthesia is more safe than the other type of central block or regional anaesthesia in a high risk patient for surgical procedure prostatectomy. In a 10 years period we have given in a 242
patients spinal anaesthesia for prostatectomy. From the complication after giving of spinal anaesthesia according to our data
were: 1. post-spinal head-ake (3-5 days) - 5 patients; 2. post-spinal head-ake (vp to 3 days) - 6 patients; 3. paraparesis (to
36 h) - 1 patients; 4. local pain on the back - 1 patients; 5. CVI - 1 patients; 6. MI - 1 patients; 7. mortality rate - 0. We can
conclude that spinal anaesthesia is one of anaesthesia of choice for prostatectomy.