Dendritic cells (DCs) are antigen presenting cells which trace origin from bone marrow cells. These cells are discovered and described by Steinman i Cohn (1973) in peripheral lymphoid organs of mice. The cellular membrane of DCs are place of expression of plenty immunoregulatory molecules such as MHC class I and II, co stimulatory, and adhesion molecules, as well as many receptors for different cytokines. Armed on this way, DCs are one of the most effective antigen presenting and immunoregulatory cells. Moreover, role of DCs in development of immune reaction can be crucial due to they are one of the most important cellular “link” between native and adaptive immunity. DCs are engaged in mechanisms of antigen processing and presentation, induction of immune reaction, establishing immune tolerance and immune reaction regulation, balancing the immune reaction between autodestruction and protection of “self” cells. These functions makes that DCs play very important role in development of some pathological conditions and diseases such as autoimmunity, allergies and quality of anti-tumor and anti-microbe defense. Unbalanced immune reaction is hallmark of all cited diseases and immunopatological conditions, so that the function of DCs should be explored on the better way.
Bryant P. Ploegh H.: Class II MHC peptide loading by the professionals. Curr Opin Immunol. 16(1):96–102.
2.
N. SS, L. RB, J.L RF. The multiple personalities of the chemokine receptor CCR7 in dendritic cells. J Immunol. 176(9):5153–9.
3.
M. L, S. B, J. H, A S. CD83 on dendritic cells: more than just a marker for maturation. Trends Immunol. 23(6):273–5.
4.
S. A, D.W. O ’Neil, N B. Recent advances in dendritic cell biology. J Clin Immunol. 25(3):177–88.
5.
A.K A. Lichtman A.H.: Cellular and molecular immunology.
6.
J.C S. Class I MHC molecules: assembly and antigen presentation. Immunol Rev. 172:11–9.
7.
R. A, R T. The ABCs of immunology: structure and function of TAP, the transporter associated with antigen processing. Physiology (Bethesda. 19:216–24.
8.
F. M, P T. Tapasin - the keystone of the loading complex optimizing peptide binding by MHC class I molecules in the endoplasmic reticulum. Mol Immunol. 39(3–4):217–33.
9.
A.G G. Van Kaer L.: Tapasin: an ER chaperone that controls MHC class I assembly with peptide. Trends Immunol. 22(4):194–9.
10.
Inaba K. Inaba M.: Antigen recognition and presentation by dendritic cells. Int J Hematol. 81(3):181–7.
11.
J.A. V, P. S, N.S W. Control of MHC class II antigen presentation in dendritic cells: a balance between creative and destructive forces. Immunol Rev. 207:191–205.
12.
D. N, P. T, A. K, D C. The ubiquitin-proteasome system. J Biosci. 31(1):137–55.
13.
M. B, A C. Ploegh H.: Membrane specializations and endosome maturation in dendritic cells and B cells. Trends Cell Biol. 14(4):175–83.
14.
Watts C. Antigen processing in the endocytic compartment. Curr Opin Immunol. 13(1):26–31.
15.
L.C H. Rudensky A.Y.: The lysosomal cysteine proteases in MHC class II antigen presentation. Immunol Rev. 207:229–41.
16.
A.B V. Kropshofer H.: HLA-DM - an endosomal and lysosomal chaperone for the immune system. Trends Biochem Sci. 24(4):150–4.
17.
I. B, B K. Najman S.: Imunobiološke osnove trudnoće.
18.
Bubanović I. Origin of Anti-tumor Immunity Failure in Mammals.
19.
Bubanović I.: Crossroads of extrathymic lymphocytes maturation pathways. Medical Hypotheses. 61(2):235–9.
20.
Hangar/1962/idc-2.html.
21.
22.
N. R, S. H, C.H. T, F K. Stoitzner P.: Langerhans cells - dendritic cells of the epidermis. APMIS. 111(7–8):725–32.
23.
R.M S. Cohn Z.A.: Identification of a novel cell type in peripheral lymphoid organs of mice. I Morphology, quantitation, tissue distribution J Exp Med. 137(5):1142–62.
24.
D.H. S, N. F, F O. Melief C.J.: Ins and outs of dendritic cells. Int Arch Allergy Immunol. 140(1):53–72.
25.
R.M. S, D. H, M.C N. Tolerogenic dendritic cells. Annu Rev Immunol. 21:685–711.
26.
M. O, S.M A. On dendritic cell-based therapy for cancers. J Zhejiang Univ Sci B.
27.
F.J. H, C. B, F. F, T.M. L, D. C, B. T, et al. Levy R.: Vaccination of patients with B-cell lymphoma using autologous antigen-pulsed dendritic cells. Nat Med. 2(1):52–8.
28.
K.C. S, G.A. P, M.D W. Apostolopoulos V.: Dendritic cells: activation and maturation - applications for cancer immunotherapy. Curr Med Chem. 12(15):1783–800.
29.
H. G, N F. Cottrez F.: Role of dendritic cells in the generation of regulatory T cells. Semin Immunol. 16(2):99–106.
30.
G.T. B, W.R H. Carbone F.R.: The role of dendritic cell subsets in selection between tolerance and immunity. Immunol Cell Biol. 80(5):463–8.
31.
B.J O. O’Neil H.C.: Maturation of function in dendritic cells for tolerance and immunity. J Cell Mol Med. 9(3):643–54.
32.
M.A. W, P S. Tisch R.: Immunoregulation of dendritic cells. Clin Med Res. 3(3):166–75.
33.
Ardavin C. Origin, precursors and differentiation of mouse dendritic cells. Nat Rev Immunol. 3(7):582–90.
34.
L.P G. Hiatt J.L.: Color textbook of Histology.
35.
Z. A, Q. S, M. P, V. A, Lj. M, N K. Petrović A.: Histološka građa organa.
36.
Mizumoto N. Takashima A.: CD1a and langerin: acting as more than Langerhans cell markers. JCI. 113(5):658–60.
37.
M.H. R, G.I K. Pawlina W.: Histology: A text and atlas.
38.
M.S. B, A.S B. Everall J.D.: An electron microscopic study of basal melanocytes and high level clear cells (Langerhans cell) in vitiligo. J Inv Dermatol. 37:516–24.
39.
Wolff K. The fine structure of the Langerhans cell granule. J Cell Biol. 35:466–73.
40.
Takahashi S. Hashimoto K.: Derivation of Langerhans cell granules from cytomembrane. J Inv Dermatol. 84:469–71.
41.
H. S, F. K, E. K, P. S, A. L, C. H, et al. Schuler G.: Disappearance of certain acidic organelles (endosomes and Langerhans cell granules) accompanies loss of antigen processing capacity upon culture of epidermal Langerhans cells. J Exp Med. 172:147–82.
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