Chronic appendicitis presents inflammation of appendix with atypical clinical findings, without significant signs
and symptoms. Because of that diagnosing chronic appendicitis presumes a great problem. Indications for operative treatment based on clinical impression are followed with a great number of unnecessary appendectomies. Barium enema can show morphlogic changes of appendix during its chronic inflammation. Our aim was to show values of barium enema in diagnosing chronic appendicitis. Study went prospectively, in period 1999-2001 on Clinic for abdominal and endocrine
surgery, Institute for surgery Novi Sad. It includes 100 patients with symptoms, 50 of them were operated after barium
enema, and other 50 were operated after clinical impression of surgeon. Each appendix was patohistologicaly examined.
Incidental appendectoies were exluded. Of total 1425 appendectomies in three years period, 100 were operatde because of chronic appendicitis. Fifty of them were operated after barium enema, and other 50 were operated after clinical impression of surgeon. Range of years was 15 59 in examined group with average 35,6 years. In control group range was 15 57, with average 32,9 years. Lasting of pain episode more than 12 hours had 94% of patients in examined group, and 72% of patients in control group had painn less than 24 hourrs. During of pain episodes at 92% of patients from examined group was 3 weeks to 12 months, and 86% of patients from control group had pain standing 3-36 weeks. The most common sign on barium enema was finding of coprolites in lumen (52%), followed with unfilled appendix (18%, angulations (10%), distal amputation (8%), segmentation of contrast (8%), and fixated appendix (4%). Intraoperative macroscopic findings were as followed: 40/50 coprolites in lumen, 7/50 fibrous bounds, and 3/50 fibroses of appendix. Patohistologicaly, chronic appendicitis was confirmed at 90% of patients in examined group, and 58% in control group. After surgery, 94% of patients from examined group don't feel the preoperative pain. Barium enema significantly increases of chronic appendicitis. It is non-invasive, and reliable method for showing morphologic changes of chronic appendix. Use of barium enema dereases number of unnecessary appendectomies. Barium enema is suggested for evaluation of patients with chronic pain in right lower quadrant of abdomen, and thereby for diagnosing of chronic appendicitis. 

Menopause may influence negatively the cardiovascular system of women, especially that of smokers. The aim of
our study was to compare lipid levels and left ventricular function in postmenopausal women smokers and non-smokers
during 12 months of oral estrogen replacement therapy. The study group included healthy postmenopausal women, 30
smokers and 32 non-smokers. Before and in 6 month intervals the following parameters were followed: total cholesterol,
LDL-, HDL-cholesterol, triglycerides, blood pressure and echocardiographic parameters of systolic and diastolic left
ventricular function. Before therapy non-smokers had higher total and LDL-cholesterol, when compared to smokers. Oral
estrogen replacement therapy significantly decreased levels of total and LDL-cholesterol and increased HDL-cholesterol,
only in non-smokers. No change in lipid levels was observed in smokers. However, women who smoked longer had higher
triglyceride levels after 12 months of oral estrogen replacement therapy. Echocardiography revealed significant improvement of systolic and diastolic left ventricular function in non-smokers, while improvement of only systolic function in
smokers. Our study has shown that 12 months of oral estrogen replacement therapy may not have a protective role on the
cardiovascular system of postmenopausal women smokers

The research was conducted at the Department of Pathology and Histology of Clinical center of Novi Sad. We analysed the reports of autopsies of newborns (to 28 days old), stillborns and miscarried fetuses in 1991 and 2001. Found
malformations were classified according to organ systems. Results for 1991 show next structure of congenital malformations: 3 malformations of central nervous system (14.29%), 0 malformations of urogenital system (0%), 3 malformations of
gastrointestinal system (14.29%), 1 malformations of musculosceletal system (4.76%), 9 malformations of cardiovascular
system (42.86%), 1 chromosomal defects (4.76%), 4 multiple malformations (19.05%). Results for 2001 have next value: 9
malformations of central nervous system (27.27%), 4 malformations of urogenital system (12.12%), 5 malformations of
gastrointestinal system (15.15%), 0 malformations of musculosceletal system (0%), 4 malformations of cardiovascular
system (12.12%), 2 chromosomal defects (6.06%), 9 multiple malformations (27.27%). By the comperison of the results of
structure of congenital malformations in 1991 and 2001, we can conclude that the differences of cardiovascular and urogenital malformations are statistically important

The frequent sign in renal disease and disease of urinary tract is presents of blood in urine, hematuria, and it is discovered very often in children. Aim of this work was to establish the most frequent causes of hematuria in our recorded
material. Investigation was accomplished on 60 patients, by using standard clinical and biochemical methods. The results of
work have showed that hematiria may be faund in any age in children. Most patients belong to age 5-10 years 27 (45.0%),
belong to age up to 10 years, and 26,6% belong to age 1 -5 year. Hematuria is more common in school-aged children and in
adolescence. Gross hematuria is found in 60% of patients, and microscopic hematuria in 40% of patients. Infective cause of
hematuria is found in 29 patients, and in 31 patients other causes, such as : stones, sec.glomerular diseases, tumors, hematologic disorders, etc. As infective glomerular disease and infection of urinary tract, in 25 % patients the cause of hematuria is acute poststreptococcal glomerulonephritis, tuberculosis in 6,66 patients,urinary tract infecion in 16,6 patients (in 8,33% patients caused by E.colli). Anatomic abnormalities is found in 15% patients,asymptomatic hematuria in 6,6%, lithiasis in 5%, and Henoch - Schönlein in 5%, and coagulopathies in5 % of patients, other causes are rare.In observed sample of patients, we have registrated high frequency of hematuria in chlidren with ac. poststreptoccal glomerulonephritis, then in children with morphological abnormalitis of urinary tract,urinary tract infection, and IgAnephropathia as a very rare cause, but Trachtman and Hagg in their reserches found Alport syndrom and IgA nephropathy as a most frequently causes of Hematuria

Powers was the first scientis who described Varices oesophagei in 1939 (Thomas in 1960) in the 19th century,
th Varices weve considered like consequence of splenies sicknes, was noted like 20 century, portal hypertension, noted like
pathogenesiscal machinery for begining. Varices oesophegei and classification. Oesophagoscopy was vade by 40 patients
because varices were veryfied and a factor of risk, which varices have was measured. Endoscopy morphologycal classification Varices oesophagei was used by Paque in 4 class. Varices in the first class was had 17,5% in the second class 35%, in the second and third class 22,5%, the fourth class 5%. Varices in the third and fourth class have observed like bigs Varices who have very risc and ruinouses for life.

On the territory of Yugoslavia Q fever presents a significant health and epidemiological problem. In Vojvodina Q
fever is being reported in epidemic form. In adition to, sporadic cases are registrated in Central Serbia as well. In Kosovo and Metohia during this period there was no single case of Q fever diagnosed. This disease is primary professional illness. Q
fever is more often diagnosed in male compared to female gender. Among reported cases elderly structures between 20 and
59 dominate and participation of those elderly groups estimate 78,4% of all registerd cases. Q fever has a strictly seasonal
character, and the most cases are reported in the period January-April

Hepatitis A is relatively benign disease. The duration of illness caused by HAV is variable, ranging from several
weeks to several mounths. Infection with HAV does not cause chronic liver disease. We have presented the clinical and
st epidemiological caracteristic an epidemic of hepatitis A in area of Toplica. Since late septembar 2001 to february of 21 in
2002, in hospital in Prokuplje have been treated 211 patients. The epidemic is spread by contact

Specific immunotherapy (SIT) has been used for almost a century but its form of administration is still a matter of
debate. At present curative SIThas only demonstrated its efficiancy, under the conditions that an appropriate allergen extract
is used, and patients are careffuly selected. However, many alergic patients likely to respond to immunotherapy are not
treated specificaly, due to the prevaling opinion that immunotherapy is ineffective, and has more uneffectable side effects
than drug treatment. Direct comparison of efficiancy between immunotherapy and drugs is problematic as this implies a
comparison between a treatment aiming at interfering with the pathophysiological mechanisms of the alergic inflammation
with potential for long term effect, or even cure (immunotherapy), and a treatment abolishing symptoms whi-le being
administered, but without long term preventive capacity (drugs). In most patients the situation is not an either but ra-ther
both and. The advantages of combinig immunotherapy and drugs are related to a higher likelihood of increasing effi-ciancy,
reducing side effects, and improving patient compliance by combining a treatment having an immediate effect with one
functioning more slowly

The level of the health protection determines the living standard of people in that area. If the standard is higher the health protection is on a higher level. Extraordinary circumstances on the territory of Kosova and Metohia in the period of th almost whole last decade of 20 century caused much lower of health protection. It happened a spontaneous mobilisation of all factors of normal life in this area, causing an improvement in this matter. First public health workers made some changes and permitted their work with a great enthusiasm. Social-political structure of this area connected humanitarian organizations while Serbian population showed a strong determination to struggle with is strength for the existence in this area. Therefore the lowest level of the health protection in 1999 started gradually to improve. By opening new section within the Health Center in Zubin Potok (orthopedic and neurological) the scope of the health protection of the people got more extended. Orthopedic section opened an X-ray room where we X-rayed injures and sickness of the locomotor systems. In the period 1999-2002. we checked 8692 sick people (42,65% workers, 49,30% housewives and pensioners and 8.30% children). However, we did 1404 surgery operation. We took out 82 benign tumors, 64 objects and 59 skin excision (removal of para-site-ixodes ricini). Nevertheless, we put 2039 bandages where injures and sickness of locomotor systems occurred. During the last 3.5 years we did 301 X-ray photos. Gradual improvement of the standard of people, improvement of the social-political situation and further strong motivation of the population to stay in this area, contributing to better medical treatment and healing of sick people. It is contributing to the existence of the Serbian population in this area.

Certainly the level of the health protection of the population is in a direct connection with the living standard of people. Life and work of all the people in Zubin Potok municipality, as well giving the health help, became more difficult after 1999. It is because of the exile of non-Albanian population from teritory of Kosovo and Metohia. The most difficult problem, taking care of sick people, results from the impossibility of the normal traffic communication with Priština and Kosovska Mitrovica, where the Main Health Centers are located. More over, the irregular supplying with medicines, difficult transportation of patients, as well the downsizing of mean in this area, made the workers of Health center in Zubin Potok to make some changes in order to provide an adequate health protection for more than 10000 people in this area.