Stress ulcer presents acute lesion of gastric mucosa, which resulted from influence of different stressors: trauma,
shock, burns, drugs administration, various irritants etc. Since pathogenesis of stress ulcer is not completely clarified, the
most adequate therapy for the patients which suffer from it, is not defined yet. Esomeprazole is a S-isomer of omeprazole
and is the first inhibitor of proton pump synthesized as an isomer. Our aim was to test effects of esomeprazole, given during
pretreatment and posttreatment period, on progress of alcohol induced stress ulcer lesions. We had experiments on sexually
mature Wistar rats weight 200-250 g. Alcohol stress was induced by intragastric administration of 1 mL 96% alcohol.
Alcohol stress produced massive submucosal lesions in glandular part of stomach. Macroscopic lesions were verified
histologicaly. Intragastric pretreatment administration of esomeprazole (20 mg/kg BW) significantly (p<0,001) reduced gastric lesions. Intragastric post-treatment administration of esomeprazole (20 mg/kg BW) did not reduce gastric lesions. Esomeprazole (20 mg/kg BW) administrated in pretreatment period of alcohol induced stress significantly decreased dimensions of stress ulcer lesions in rats, while the same dose administrated in posttreatment period did not cause that effect.

It is known that the intoxication with heavy metals and pesticides is most often unmedical poisoning. In contrast to other heavy metals, for example: mercury, lead, cadmium and zinc, toxic copper activity and the mechanism of its effect are not known enough and they are not yet explained. Because of that, the aim of this work was ( with acute dog intoxication with copper sulfate ) to contribute to better clearing of biochemical mechanism as a result of copper toxical effect and to make analysis of its tissue distribution. Researching was done on adult dogs, both sexes, different races and body mass of 14- 20 kg, who were given a 10% water solution of copper sulfate in the dosage of 33mg/b.m. divided into 5 equal doses. The analysis of biochemical blood structure took the following things: total proteins, albumins, globulins, total lipids, chole2+ sterol, glucoze, transaminase (AST,ALT), catalase, peroxidase, vitamin C, proteine SH, the contretation of Cu in the serum 2+ and the content of Cu in the tissues. The results are presented in the charts and graphic presentation. All these changes can be the important directions in an biological monitoring as a biochemical indication of copper pollution in the surroundings.

Bacterial meningitis is an important medical problem, as because of the use of powerfull antibiotics and other
drugs, and therapeutic measures, the number of patients, as well as the mortality haven't been changed for years. Because of that the study of pathogenesis of bacterial meningitis has been one the most dynamic researsh fields in recent years. Meningitis caused by salmonella is not usual clinical manifestation of salmonella infections, but because of fulminant evolution and specific structure of cause. Path and effect of diseases, it deserves special attention. Our researches encompases 29 children who suffer from salmonella meningitis. Out of the whole number of cured children, the moust frequent was at newborn (58,6%), while the smallest number was in the group of older infant (6.9%). Concernig the sex structure of diseased, the biger number was at male (62.0%). The most important finding in liquor cerebrospinalis at patients is polymorphonuclear leucocytosis (average value of cell elements is 3744, with 82% polymorphonuclears). At the same time existed leucocytosis in peripheral blood with sigificant deviation into left. At all our patients hypoglycorachya expressed (1.45mmol/L). The value of proteinorachya was 1.71 g/L. The result of the disease was successful in 49.3%, died 24,1%, and cured with consequences 27,6%.

Pustulosis subcornealis is a chronic recurrent disorder with primarly sterile pustular lesion, initially bean-sized. The initial distribution is symmetrical and disseminated. The pustules is affected the trunk and the proximal extremities. A rare condition, affecting women. We want to present a woman with a characteristic subcorneal pustular lesions on the clinical findings and histpatology examination.

Women sexuality is a complex phenomenon encompassing biological, psychological, emotional and social aspects. The menopausal changes have undoubtedly a significant influence on sexuality. There is a widespread opinion that older women show a fading interest and desire for sexual relations. However, despite of all unavoidable changes brought about by menopause and elder age, the sphere of sexuality remains still very important. The paper reviews the changes occurring in the sphere of sexuality in the older age, influence of menopausal hormaonal changes, psycho-social factors and general health state in these changes, as well as of the possibilities of treating sexual dysfunctions in the menopausal period.

The thyroid gland produces two major active thyroid hormones, thyroxin (T4) and triiodothyronine (T3). The production of these hormones within the thyroid is regulated by thyreotropin (thyroid-stimulating-hormone- TSH). Iodine deficiency is the most common cause of goiter and borderline hypothireoidsm word-widw. In non iodine deficient areas, however autoimmunity is the most common cause of hypothyroidism. Destructive therapy by surgery or radioiodine for thyrotoxicosis acounts for approximately one third of all cases excessive iodine (e. g. as e result of chronic ingestion of proprietary cough medicines) may also cause hi pothyreoidsm. Primary hypothireoidsm due to failure much more common than failure secondary to pituitary dysfunction, or tertiary hypothireoidsm due to hypothalamic disease. The symptom of hypothireoidsm are non-specific and may be attributed by bath patient and doctor to ageing the onset usually being insidious. Hypothireoidsm is treated with replacement T4 therapy. The author describe a 55 year-old women with diagnosis of Primary hypothireoidism. The disease had a rarely course with disorders this metabolism lipids and complications here cardiovascular system. 

Dysplasio epiphysialis is congenital disorder of ossification and development of epiphysis that lead to deformation of epiphyses. This disorder of is not so frequent (1). Etiology is unknown. It appears in both sexes in the same percent, sporadically, but in the several members of one family also (2). It appears in two forms, polyarticular and oligoarticular. Clinical feature characterize low growing (150-160 cm) with short clumsy fingers, incrassate joints and limited mobility. Especially characteristic of this disorder is discrepancy between low degree of subjective complaints and marked radiological changes. (1). Laboratory findings most often are not specific. Metabolism of calcium and phosphorus is not changed (2). Radiological is characteristic irregular aspect of joint flanges and articulating surfaces and narrowing of the joint spaces, cartilage sclerosis, cystic changes in joints and, not so often periarticular chondromatosis. Vertebral joints if geared manifest platispondilia and ragged of vertebral joints surfaces (2). Conclusion: Dysplasio epiphysialis multiplex is characterized with specific clinical and radiological feature and appearance in jung ages; it is often substitute with primary generalized osteoarthrosis or rheumatoid arthritis (our case). From those reasons it is very important to recognize the specific nature of this disease for the therapeutic and prognostic purpose.

We presented you six patients suffering from phlegmona periurethralis. It is mens' disease and, in the greatest degree, it appears at stenosis and urethra trauma. The commonest case of this disease are patients suffering from diabetes and those who carry catheter all the time. The appliance of a large doses of antibiotics and early incision with drainage can help patients to be cured. Urine derivation is very important and it must be like minimal cystostomy

The injuries of genital organs are commonest today regarding to the fact that there are different kinds of firearms and contact mines, although testicles are well protected in thigh area. In cases where we have maximum testicles injuries the conservative surgical treatment should be applied, considering the fact that testicles have great power of "restitucio ad integrum".

In well organized societies, accept of material and technical progress, planning of the family and existing of human resources is of great importance. Every civilized society is tancing care of human potential, planning and progress, eather to stimulate or control of natural increase are bringing the suitable demographics of standards. With better family planning asspecially motivatiy the couples to decide for reproduction and delivering of optimal namber of children in optimal period between deliveries and in optimal ages, brings to decreased mortality among new-borns, and also their mathers.