Chronic pulmonary heart (CPH) stands for presence of hypertrophy and/or dilatation of right heart ventricle caused by pulmonary hypertension as a consequence of diseases that are damaging lungs function or structure. By chronic pulmonary heart are not considered those hypertrophies of right ventricle which are consequences of left cardiopaths or congenital heart anomalies with skips. During the CPH evolution three stages were formed: a) uncomplicated pneumopathology, b) compensated chronic pulmonary heart and c) decompensated chronic pulmonary heart. The disorders of cardiac rhythm are often at decompensated CPH, which is proved by this scientific work as well. 40 sick people diseased of decompensated CPH are treated in purpose to establish the presence and the characteristics of cardiac arrhythmia at these patients. It is established that the major percentage of frequency is made by sinus tachycardia, atrial extrasystols, and ventricular extrasystols. Of 40 examinees 65% had sinus tachycardia, 37,5% atrial extrasystols, 30% ventricular extrasystols and 20% combined atrial and ventricular extrasystols. This proves us that there is a significant percentage of cardiac rhythm disorder frequency at the sick people of decompensated chronic pulmonary heart.

Besides big improvement of diagnostic, therapeutic and preventive procedures vascular disease generally and vascular disease of brain remain of biggest importance in total morbidity and mortality. This examination included patients in Urgent Surgery Center “Simonida” Gracanica. In article is represent relationship between brain and heart dysfunctions and it is obvious that cerebral disturbances can cause heart disturbances and also it can be in opposite direction. Well, based on this is very important to make fast and correct orientation: CARDIOCEREBRAL or CEREBROCARDIALSYNDROME. In diagnostic procedure and therapeutic treatment is necessary cooperation between cardiologist and neurologist because in most of these cases we have cardiocerebral or cerebrocardial syndrome. Better treatment patients with brain stroke claim teamwork different specialist.

Defined daily dose (DDD) is arbitrary chosen technical unit for measuring medicament usage and it is not a recommended therapeutic dose. It is in fact a statistical parameter for monitoring medicaments usage, and it is related to the dose which is usually prescribed for the indication that the medicament was registered for. The aim of this work is to perform a detailed analysis of the extent and structure of the region of South Backa. Antiinfective medicaments in systematic use, according to the obtained data, participate with only 7.96 DDD/1000 inhabitants. The most applied pharmacotherapeutic subgroup with 2.99 DDD/1000 inhabitants is comprised of cephalexine and cephachlor. 

Ahigher concentrations of microorganisms in the vagina can lead to preterm delivery. Bacterial vaginosis is a well known risk factor of preterm delivery. Aim of this study was to estimate the presence of bacterial vaginosis as a potential cause of preterm delivery relative to the patients with term delivery, as well as to define the type of present bacteria. The results of our investigation showed more frequent presence of bacterial infection of the vagina in the patients with preterm delivery. The following bacteria have been cultured in the group of patients with preterm delivery: Streptocossus agalctiae, Enterococcus, Staphylococcus sp. and Escherichia coli. In prevention of preterm delivery, we recommend a routine screening of pregnant women (such as obtaining smears to bacterial infection) as well as administration of the therapy in case of positive findings, particularly in those presenting a risk for the development of bacterial vaginosis and preterm delivery. 

Premature labour is provoked by noumerous causes that represent a combination of socioeconomic, maternal and fetal factors, that usually act together. The introduction of of tocolytic agents in obstetric practice has not appeared to substantially change the incidence of preterm delivery. This problem is still one of the unsolved ones in perinatal medicine. The aim of the study was to present how structural and functional anomalies of placental physiology can be connected with this disarrangement of pregnancy.In our study of 327 pregnancies controled in our unit in 41 (13,26%) symtoms of premature labour were present: contractions, vaginal bleeding, abrevation and dilatation of cervical ostium. With adequate treatment, in form of combination of tocolytics, spasmolytics, hormones, nonsteroid antiinflammatorz drugs, antibiotics and atimycotics we have posponed delivery to term in 34 (82,92%) of cases. The use of appropriate medications, that blocks pahtophysiological mechanisms responsible for preterm labour in most cases we can enable prolongation of gestation and term delivery.

In regulation of specific immune responses the most important role play interleukin-2, IL-4, IL-5, IL-13, inter feron- (INF- ), transforming growth factor- (TGF- ) and lymphotoxin (LT). These signal molecules are produced mainly by T-lymphocytes after recognition of foreign antigens by specific receptors (TCR) placed on plasmalema. Some of mentioned cytokines stimulate proliferation and differentiation of various lymphocyte populations in the activation phase of T cell-de pendent immune responses, while the others activate and regulate the function of specialized effector cells, such as mono nuclear phagocytes, eosinophils, and neutrophils, to eliminate antigens in the effector phase of immune responses. In con trast to most of cytokines which have stimulating action on an initiation and course of humoral and cell-mediated immune responses, TGF- has an inhibitory effect on the activation and proliferation of T-lymphocytes and the other leukocyts

Osteoporosis is a condition chracterized by a reduced amount of bone which leads to diminihed physical strength of the skeleton and an increased susceptibility to fractures. There are many causes of osteoporosis but the most common by fair is due to the decrese in the amount of bone which occurs after the menopause, the so called postmenopausal osteoporosis. There is no evidence that postmenopausal bone loss itself causes any symptoms and ensuing osteoporosis has therefore been called «the silent epidemic».

There are different reports regarding the characteristics of examined quality of life (QOL) in patients with combined coronary and valvular surgery. Objective was to compare the quality of life changes after isolated coronary and associated coronary and valvular surgery. From February to May 2002, we prospectively studied 243 consecutive patients, who underwent elective CABG. The Nottingham Health Profile Questionnaire part I (NHPpart I) was used as a model for QOL determination. NHPpart I contains 38 subjective statements divided into six sections: physical mobility (PM), social isolation (SI), emotional reaction (ER), energy (En), pain and sleep. The scores ranged from zero to 100, by adding the item weight, determined by Thurstone method of paired compares, to every positive answer. We distributed the questionnaire to all patients before and six months after CABG. Two hundred twenty six patients filled in the postoperative questionnaire. An isolated coronary heart disease was present in 218 patients (89.71%), and associated coronary and valvular disease in 25 patients (10.29%). Preoperatively, there is no difference in QOLamong the examined groups. After operation, quality of life was improved in 84.65% (171/202) of patients using coronary surgery and in 79.17% (19/24) of patients using combined (coronary and valvular) surgery. Quality of life was statistically improved in the first group of patients in all sections, and in the second group of patients in 4 sections (PM, En, pain and sleep) (p<0.05). There is no significant correlation between the quality of life changes after operation and the type of surgical procedure. By univariate and multivariate logistic regression, combined procedure distinguished as the independent predictor of QOL worsening in the ER section (p=0.012, OR=3.62, 95% CI 1.32-9.92). Six months after CABG quality of life was significant better in most of patients in both studied groups. Associated coronary and valvular surgical intervention distinguished as the independent predictor of quality of life worsening in the ER section.

Parameters of anaerobic capacity were investigated in the group of 90 young subjects classed into diferent groups depent on their physical fitness. The group consisted of 30 wrestlers, 30 rowers and 30 students. Basic antropometric parameters were taken for each person and than Wingate anaerobic test was administrated. The aim of this investigation was to measure anaerobic parameters and determine weather there was a difference among sportsman and non sportsman. All parameters of Wingate test (anaerobic power, explosive power, anaerobic capacity) were significantly higher in the group of sportsman. (p0.05) Also, the highes values od anaerobic parameters were detected in the group of wrestlers, since this is typicaly anaerobic sport. The lower values were measured in the group of non sportsman, as expected.

In essential hypertension, hemodynamic changes in systolic and diastolic function acompany left ventricul hypertrophy ussualy. Both of these cardiac function can be detected with echocardiography and were measured during this study. 23 patients with moderate essential hypertension were treated with cilazapril plus small doze of diuretic (hydrochlorothiazide) once daily for 120 days. On the begining we found diastolic disfunction, but after the treatment there was a significant improvement in isovolumic relaxation time, early diastolic filling pattern and normalized left ventricular early/ atrial filling ratio. Cilazapril + diuretic combination in a dose once daily controlled blood pressure satisfactory, too. Parameters of systolic function were in the normal levels and there were no significant changes between the two determinations. Thickness of the interventricular septum and posteroinferior wall did not change significantly after 16 weeks of therapy, probably because of too short time of investigation.