One the of most importante charactersistics of drug is a drug safety. However, there is no absolute safety. Medicines are troughly tested in controlled clinical trials with limiting population and short duration. Experience has shown that much of our knowledge about a medicine becomes available during the subsequent prescribing practice. Therefore there is a need for continued monitoring medicines after granting of product licence for a new drug (phrmacovigilance). WHO international system for drug safety monitoring as maintained by the Upsala Monitoring Centre (UMC) in Sweden, has built up vastedatabase of reports of suspect adverse drug reactions, coming from national centres in 75 countries in all of the world. The international system products valuable information from countries around the world, to support regulatory follow-up and decision-making. Emphasis is on those signals that may remain at the national level, because of small numbers or absence of local reports. The aim of the WHO's international pharmacovigilance program is a safe and rational medicines evrywhere. In Serbia as of 2005. National Medical Devices Agency is acting on behalf of the Ministry of Health as National Centre for Adverse Drug Reactions. The form for reporting adverse effects of medicines, in both pre-marketing and post-marketing phase can be found and downloaded in Word format on the Agency`s web site www.alims.sr.gov.yu.

Reactive products of oxygen are among the most potent and omnipresent threats faced by the living organism. Intracellular accumulation of reactive oxygen species such as superoxide anion, hydrogen peroxide, hydroxyl radical, and peroxy radical, can arise from toxic insults or normal metabolic processes. These species may perturb the cell's natural antioxidant defence systems, resulting in damage to all of the major classes of biological macromolecules, including nuclear acids, proteins, carbohydrates and lipids. Oxidative stress has been defined as a disturbance in the prooxidant-antioxidant balance, resulting in potential cell damage. It has been implicated in several biological and pathological processes like ageing, inflammation, carcinogenesis, ischemia-reperfusion and in diseases including diabetes mellitus, atherosclerosis, and/or neurodegenerative diseases

In average 2% cases cause of blindness are mechanical injuries of the eye. This retrospective study was conducted in a 6 years period (from 1990 to 1995). Regarding to demographic data (74% were male with domination of children up to 6 years old of among age structure 151 patients, or 23%;The most numerous were pupils and students (247 or 37%).1% of patient were injured both eyes in the same time. The most common cause of eye trauma was wood (28%) and during the playing time (48%) and at home (27%). At 25 patients evisceration and enucleation were performed. Visual acuity was satisfied or good at 52% patients at the reception but on admission result was better: 68%

Nowadays, hysterosalpingography and laparoscopy are routine methods of exploration of the oviduct passability.The tests were made at department of infertility at the Gynecology and Obstretics Institute of Clinical Center of Serbia in the period from 01.01. untill 31.12.1998. The three hundred patients, on which hysterosalpingography (HSG) was made, and patients, on which chromolaparoscopy was made, were involved by prospectus studies. The analysis shows, that between hysterosalpingographical and laparoscopical investigation of the passability of the oviducts there exists an extremely high statistical difference in the distributions of findings of particular modalities of the passability of the oviduct. Two-way passability of the oviducts with growths of tissue has been established in a higher percentage in the patients who were examined laparoscopically, while the other alternations have been diagnosed hysterographically i a higher percentage. A statistical processing of data resulted in a significantly high statistical difference in the patients with two-way occlusion of the oviducts, whereas for other modalities no statistically significant difference has been established. The most researchers describe high perccentages of growths of tissue, from 64,0% to 72,0%, which have not been established by HSG. Growths of tissue have been confirmed by this investigation in a high percentage (70,0%). Establishing the passability of the oviducts is particularly important for further treatment of the patients.

In process of chlorine-alkali electrolyze the big mercury failure exist in vapor shape, which across respiratory system, expire in exposed persons organism. The aim of the work was to examine connection between mercury vapor air pollution and sicknesses coming from diseases belonging to the XI group of diseases by International Classification of Diseases th (ICD) - 10 revision. Exploring groups were workers “Kalium chemistry” factory and administration at CI ”Zupa”. Recognized diagnosis on periodical exams year 2000, 2002 and 2004 were entered in reports (expertises) analyzed later on. Analyzed reports for total 571 examinees were done, 184 examinees year 2000, 191 examinees year 2002 and 196 year 2004. As of diagnosis recognized the diagnoses were separate for diseases belonging to XI ICD group. Examinees were divided in a four group according to the grade of exposure: I group day by day exposed; II group sporadically exposed; III group earlier
exposed; IV group not exposed. First, second and third group of examinees were workers of “Kalium chemistry” factory. It was established during the examination at rooms were exposed workers stay that only mercury vapor pollution 3.01 overcomes Maximum Permitted Concentration allowed by JUS. The frequency differences testing between groups according to the grade of exposure, like as frequency differences testing of sicknesses between all exposed opposite un-exposed, showed
to us that differences are statistically significant. Based on the results of the this research it can be conclude that connection exist between mercury vapor air pollution and sicknesses coming from diseases belonging to the XI group of diseases by ICD.

Gonarthrosis is the most frequent artropathy of knee.The second joint of frequency and localisation osteorthrosis after joint of haunch. In complexive therapy of gonarthrosis, exept the medical therapy, important place has physical therapy
or special laser-therapy. 78 patients, where tested with a primary and secondary gonarthrosis, 19 men, and 59 women. They were all hospitalised on Rheumatology department of Internal Clinic of Clinical and Hospital Centre in Pri{tina. By objective using of parameters we show that, laser is a very important modern expedient on clinical results for gonarthrosis (volume of joint, volume of movements, muscle strength, and on the first pain, pain in static positions, pain in moving and night pain). It is seen that all values got by laserotherapy are statistically high significiant. During the use, of laserotherapy, the medical therapy was included.

Natural system of disease genesis is a complex occurrence. «Net» review of cause can be based on systematic approach and it doesn't have to, and so those are homonyms. Complex occurrence of the genesis of a disease is given as a arranged set by relation «predecessor-follower». Chain reaction is that one which has hierarchic arrangement because of managing. By systematic approach the causality is being created.

Change in left ventricular volumes, particularly end-systolic volume index is a major representative of left ventri cular dilatation, and is a predictor of mortality after acute myocardial infarction of anterior localization. Several large-scale trials have demonstrated beneficial effectiveness of ACE inhibitors on the process of left ventricular remodeling after myo cardial infarction, not only in patients with compromised systolic function. Aim of the study was to evaluate the influence of therapy for ACE inhibitors in the early faze of anterior myocardial infarction, trough dynamics of left ventricular volume in dexes. During six months 30 patients were evaluated with echocardiography in admission, before leaving the hospital, after
three and six months after myocardial infarction. In evaluated group there was increased end-diastolic and end-systolic vo lume index, but without statistically significant value. There were no new cardiac decompensations. We concluded that ACE inhibitors given in the early stage of acute myocardial infarction anterior localization have beneficial effect on the process of left ventricular remodeling and that is recommended to bee given to this patients, after excluded contraindications

Biliary calculosis is the most frequent disease of the hepathrombial system. Inflammation of the gall bladder appears in the acute and chronicle form. Acute inflammation presents one of the frequent complications of the gall bladder
calculosis. Acute inflammation of the gall bladder can appear in catarrhal, phlegmonous, gangrenous perforative form. Perforation of the inflamed changed gall bladder can lead to the diffuse biliary peritonitis, pericholecystitis and formation of
pericholecystitis infiltrate or abcess. Very often the acute inflammation of the gall bladder appears in combination with Acute inflammation of the pancreas. For the production of the work the biyearly material of the Emergency Surgical Centre
“Simonida” in Gračanica is used. In the ESC Simonida, in the period from January to December of 2004, 375 patients were operated. In the same period of time we operated 52 (13.86%) patients because of the gall bladder disease and biliary ways.
There were 45 female patients and 7 male ones. Gall bladder disease is 6.5 times more frequent at females in our material. Hard security situation and limited freedom of movement are one of the most important reasons of patients' late report to the
doctor, and appearance of the heavy forms of the inflammation of the gall bladder and biliary ways. The acute form of the inflammation of the gall bladder was noticed at 25 patients. The complications of the disease in the sense of cholecystopancreatitis, choledolithiasis, suppurating cholangiitis, choledolithiasis i cholecystoduodenal fistule were found at 27 patients. Postoperative complications were verified at 3 patients, wound infection at 2 patients and peritonitis at one
patient after drawing ouf the T-drain.

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Diabetes mellitis,type 2 is often associate with disorders metabolism of lipid. That is base for development athero sclerosis, coronare disease and peripheral vascular complications. Patient with diabetes earlier get cariovascular disease. Frequency in equllent in female and male sex. Atherosclerosis is proces which is started earlier in patiens with diabetic, than in healthy population. So, prevention of cardiovascular disease is very important. When we elimination risk factors: smoking, hypertension and lipids, we will reduce coronary syndrome.The clinicly studies show us that the statins drugs are choice for prevention and controle metabolism lipids in these pations. Statins drugs had been show us the best therapy the efects on evolution of atherosclerosis plaques, reversed endothel disfunction and modulation of thrombotic parametars