Drugs prescription and drugs accessibility are among the most important drug use related topics. A patients questionnaire was conducted in the area of Novi Sad, Bačka Palanka, Bač, Temerin and Odžak (all in South Bačka region), because the routine medical statistics does not provide all neccessary data about the drugs availability. It is demonstrated that pressure and expectations of patients and doctor-patient relationship influence the choice of drugs to be prescribed. Positive list drugs deficiency represent a great problem, forcing patients to buy drugs in private-owned stores or abroad.

The birthrate in Serbia has been falling and we are the last country in Europe according the number of newborn children. The aim of this study was to establish the birthrate trend during the period of five years on the territory of Central Kosovo and Metohija, according the data of Gynecology- Obstetrics Clinic/Gracanica, to indicate the importance of an improvement of women's health care, increase the birthrate and population growth rate. There was used a retrospective method of examination of the data from the maternity hospital register in Gracanica. There were also used the data from the death registry in the local community of Donja Gusterica and the records of students enrolled into the first grade of Primary School in Donja Gusterica. During the period from March 2002 to August 2005 there were born 1718 children (912 boys and 806 girls). There is almost no family on this territory with less than three children and there is a significant number of families with four or five children. The number of women who bore six times was 24, seven times was 13 and eight times was 11 while there were two women who born the ninth child and one woman who bore the eleventh child. During the five-year period, on the territory of local community of Donja Gusterica, there died 169 people while, at the same time, the number of students enrolled into the first grade of primary School was 293. An important contribution to growth of natality is an improvement of the women's health care. There was noticed a constant increase in number of newborn children for the mentioned period as well as a significant increase in population growth rate in Central Kosmet

Hypokaliaemia can be cause for beginning cardiac arrhythmias in patients with acute myocardial infarction. The aim of this investigation is to determine correlation between kalium level in serum and cardiac arrhythmias and conveying, to note down in first 24 hours in patients with acute myocardial infarction (AMI). Patients in this study attended in department of Internal medicine(coronary department ) in hospital in Health center in Kosovska Mitrovica.In this prospective study for one years we analyzed 110 patients with diagnosis of acute myocardial infarction. We found that cardiac arrhythmias represented in the most noumber of patients in the first 24 hours from receiving in hospital- 83,63%.The patients have had the more noumber of complex VES(20,91%),SVT(18,18%) than other cardiac arrhythmias in the first 24 hours from their received in the hospital. The low level of kalium have note down in 9,09% patients. The comlex VES have represented in patients with low level of kalium as VF. In the presence of kalium level under the 4,0 the risk for ventricular arrhythmias is higher.SVT have had in 20% patients with acute myocardial infarction,SVB in 10%,SVES in 16%,VF in 7% patients with normal kalium level in serum as branch block and AV-block I, II, III degree. Hypokaliaemia have influence on represence of VES and VF, but have not influence on represence of supraventricular arrhythmias and the disorders of conveying.

Dendritic cells (DCs) are antigen presenting cells which trace origin from bone marrow cells. These cells are discovered and described by Steinman i Cohn (1973) in peripheral lymphoid organs of mice. The cellular membrane of DCs are place of expression of plenty immunoregulatory molecules such as MHC class I and II, co stimulatory, and adhesion molecules, as well as many receptors for different cytokines. Armed on this way, DCs are one of the most effective antigen presenting and immunoregulatory cells. Moreover, role of DCs in development of immune reaction can be crucial due to they are one of the most important cellular “link” between native and adaptive immunity. DCs are engaged in mechanisms of antigen processing and presentation, induction of immune reaction, establishing immune tolerance and immune reaction regulation, balancing the immune reaction between autodestruction and protection of “self” cells. These functions makes that DCs play very important role in development of some pathological conditions and diseases such as autoimmunity, allergies and quality of anti-tumor and anti-microbe defense. Unbalanced immune reaction is hallmark of all cited diseases and immunopatological conditions, so that the function of DCs should be explored on the better way.

One the of most importante charactersistics of drug is a drug safety. However, there is no absolute safety. Medicines are troughly tested in controlled clinical trials with limiting population and short duration. Experience has shown that much of our knowledge about a medicine becomes available during the subsequent prescribing practice. Therefore there is a need for continued monitoring medicines after granting of product licence for a new drug (phrmacovigilance). WHO international system for drug safety monitoring as maintained by the Upsala Monitoring Centre (UMC) in Sweden, has built up vastedatabase of reports of suspect adverse drug reactions, coming from national centres in 75 countries in all of the world. The international system products valuable information from countries around the world, to support regulatory follow-up and decision-making. Emphasis is on those signals that may remain at the national level, because of small numbers or absence of local reports. The aim of the WHO's international pharmacovigilance program is a safe and rational medicines evrywhere. In Serbia as of 2005. National Medical Devices Agency is acting on behalf of the Ministry of Health as National Centre for Adverse Drug Reactions. The form for reporting adverse effects of medicines, in both pre-marketing and post-marketing phase can be found and downloaded in Word format on the Agency`s web site www.alims.sr.gov.yu.

The aim of the paper was to investigate whether nutrition based on animal fats in the group of patients who used them as dominant-group S ( the patients of Greek Orthodox creed), is a more signifikant risk factor in the development of stroke than nutrition based on vegetable fats-group A( the patients of Muslim creed). At the same time, the aim of the article was to find the parameters of lipid status which would define in a better way the connection between hypercholesterolemia and apoplexy. The research was done on 230 patients with ischemic CVI who underwent hospital treatment at the Neurological Clinic of the Clinical-Hospital Centre in Pristine. The patients at the Neurological Clinic of the Clinical-Hospital Centre in Pristine were divided into two groups: Group A (n=130)- the patients who based their nutrition mailnly on vegetable fats (the patients of Muslim creed) and Group S (n=100)- the patients who based their nutrition mainly on saturated fats ( the patients of Geek Orthodoc creed). It was stated that the intake of both vegetable and animal fats in larger quantities bears a risk of the development of the cerebra-vascular insult. The intake of saturated fats is a higher risk factor leading to the increased values of cholesterol, triglycerides and LDL-cholesterol in the group of patiebts of Greek Orthodox creed (group S) in comparison to the group of patients of Muslim creed (groupA).

Gonarthrosis is degenarative knee disease as well as the commonest chronic knee arthropaty. Nowadays more attention is given to modern pathogenesis of arthrosis in two levels: 1. immunological; 2. some ferments disbalance phenomenon. In the second level of pathogenesis, a special atention is given to metalloprotheasis. The importance of doxycyclin on the reduction of metalloprotheasis in synovia has a great therapy importance not only theoretically but pratically as well 78 patients with primary and secundary gonarthrosis has been examined (19 men and 59 women) the appliance of doxycyclin in clinic elements common for gonarthrosis caused the improvemnt of all clinic parameters especially muscular strenght and pain, but the largest improvement was noticed in knee - joint circumference

Seronegative arthropathy represents group of rheumatic diseases which affects younger patients, more often male. Ocular findings are numerous such as conjunctivitis, iridocyclitis, and they are a part of extraarticular clinical manifestations. Acute anterior uveitis, as most common ocular manifestation, could be a sole or associated morbidity condition at the forme of systemic diseases

In average 2% cases cause of blindness are mechanical injuries of the eye. This retrospective study was conducted in a 6 years period (from 1990 to 1995). Regarding to demographic data (74% were male with domination of children up to 6 years old of among age structure 151 patients, or 23%;The most numerous were pupils and students (247 or 37%).1% of patient were injured both eyes in the same time. The most common cause of eye trauma was wood (28%) and during the playing time (48%) and at home (27%). At 25 patients evisceration and enucleation were performed. Visual acuity was satisfied or good at 52% patients at the reception but on admission result was better: 68%

Diabetes mellitus is the most frequently chronical disease.In the relation on the degree of affection populations (over 150 000 000 peoples), was able speak about pandemic of this illnesses. In the orgin of insulin-indipendent diabetes mellitus, the primary role has the insuline resistence. Date from literature gives the evidence that the metformin is a drug for insuline resitence. Behaind the rest, has been proved that metformin, decrease risk factors for beginning complications this illnesses