In two refugee camps, near K.Mitrovica (in little colliery city), gipsys refugees dislodge by Albanians were temporary located. In their blood, lead contamination is discovered. All together 310 children, 1-14 years old, were contaminated by lead. Examination and treatment is implement by the SZO patronage, which took capillar blood samples from 298 children and vein blood samples from 190 children. Level of lead, in 47 cases was more then 45 microgram./dl. All the children with high level of lead had physical and laboratory tests. Also, they were under special food diet, with a lot of calcium. In 45 cases, per os treatment is used with “Chemet” medication, produced by McNeil-USA.Only in 9 cases, week bad reaction was notice using this medication. In some isolated cases, headache, pain in stomach, sickness and sleepiness. This difficulties didn't required therapy cancelation. Treatment was fully successful except in two cases, where therapy was repeated.

As a result of long-term heroin abuse we can see impairment of cerebral structures, that leads to specific deficits in cognitive and conative area. There is a positive correlation between intensity of mentioned deficits and duration of heroin abuse. Attention is a cognitive function highly sensitive to toxic effects of opioids. Attention disorders and concentration disorders in opiate addicts are frequently described as a part of frontal syndrome, in consideration of high neurons sensitivity of frontal and prefrontal cortex to heroin. The aim of this study was to evaluate results of heroin addicts on Trail making test, in order to estimate the effect of heroin abuse on attention and specific relation between attention deficit with the duration of abuse. Ninty heroin addicts, divided in tree groups, regarding to abuse duration, were included in study. Results showed that heroin abuse longer than one year is connected with attention disorders, like low flexibility of attention and low selectivity of attention. The intensity of mentioned effects is higher in addicts who use higher daily dosage of heroin

Arteriovenous graft are the most frequent alternative to the arteriovenous fistula. Although arteriovenous grafts 'mature' fasterthan endogenous fistulas, at least 3 weeks are needed before the first puncture to allow endothelialization of the internal wall. Implantation of arteriovenous graft is foreign material, are subjected to a high risk of thrombotic and infectious complications.

Every time, even ours, has its own «driving forces, starters and breakers». Dr Vladan Djordjevic resided during the very noisy time during the second half of the nineteenth century, known for intensive changes in biology and medicine. Contemporaries noticed peculiar nature of Dr Vladan Djordjevic: clairvoyant, cleverness - «gave more, than many other simple professionals together». If even nowadays the way of how a man thinks is not known, that is logical structuralism and logical functionality of thinking, scholastic is wrong that such a «natural thinking», certainly, enters into cliché. The author applied nine-valence logic and systematic approach. The measures in eradication of diseases which, used to be applied nowadays would be called "general hygienic measures". They didn't have to be sufficiently effective, so the possibility of appearance for some sick stayed, because it would appear in natural system of appendage, few «causative connection», but noticeable less that earlier. The helth ones exposed can be used for prooving cause, which contemporary statistic doesn't use for this purpose. By this, even when we have not existing of statistic importance it points out at the cause; that is, the existence of this one can direct someone to wrong road. The difference in the value of the result of the same event points out at the researches not being orientated and by that cosmopolitan community. Palliative measures made the doctors confused, as it was perfectly noticed by V. Djordjevic - "...he wouldn't make a mistake to prove, how people get sick and die because they are better dressed, better feed, because all their life is better organised than it used to be", although the group progressed by its better working. Multy valence »logic of allowance” as a natural and objective one, used to exist before its observation by logic and science. The result is «clairvoyant and restless spirit» of the future academic Vladan Djordjevic D. M. what is even nowadays desirable. The author concludes that there is one road to discover something (anticipate) by adding importance to «statistic importance»; and the other one, chosen by Dr Vladan Djordjevic by your own ratio (intuition). Although the disease appeared even when the progress is made - he didn't allow: «not to see the whole forest because of one wood», and to underestimate the applied measures. He didn't allow to be deceived by appearing of disease, because the palliative of measurements covers the system: а. When you are not successful, but and b. Even when you are successful - and those have to be separated by contemplation and by no means unifies!

Rituximab is a human/mouse chimeric IgG1 monoclonal antibody that specifically targets the CD20 surface antigen expressed on the cell surface of all preplasma cell stages of B-cell differentiation. By binding to CD20, rituximab causes selective B-cell depletion through antibody-dependent and complement-dependent cell lysis and apoptosis. B-cell depletion is believed to disrupt the many B-cell functions that contribute to the pathogenesis of RA. The purpose of this study was to examine the efficacy and safety of RTX an anti-CD20 B cell depleting monoclonal antibody in combination with methotrexate (MTX),in patients with rheumatoid arthritis who experienced an inadequate response to one or more TNF antagonists and had active disease despite ongoing treatment with MTX and a TNF inhibitor. ACR responses in RTX treated patients were superior to placebo. The primary end point was the proportion of patients in each group that achieved an ACR20 response at Week 24. Secondary endpoints included ACR50 and ACR70 responses, changes in Disease Activity Score (DAS28), and EULAR response

Important facts about recombinant human factor VIIa have been mentioned, also about the renal cell carcinoma. Case report: Male, aged 69, with infiltrative renal cell carcinoma, underwent radical nephrectomy using Hasagawa`s approach. Extirpated tumor had 35 cm in diameter. During the surgery, patient suffered a cardiac arrest with 3500 ml blood loss. After operation, he lost 2100 ml more blood. Despite of active blood supstitutions with intensive surgical attempts in order of haemostasis, bleeding did not stop untill the application of rFVIIa (300 I. U.). Patient survives and recovers completelly. Conclusion: RFVIIa is very succesful in controling of massive surgical bleeding, possibly associated with paraneoplastic syndrome.

Prepathogenesis of mass occurrence of disease as a complex happening is hiding the “screen”. Social influence remained hidden inside school «25. may», which had as a consequence shown higher distribution of manifested disease. As the main point at performance of events is scientism based on “black box system”. There is uncritical trust in paradigm, statistic methodology there comes “parroting”. Sheltered by screen content of the events, between the enter of the first (sub)system and exit of the final (sub)system the most critical maintain “mixed approach”, with the aim to reveal into the real dynamics by “natural happening of mass disease”, into “driving force” that is causes of self moving - spontaneous genesis of epidemics: a) for mass effects of it is 'natural work' (appropriate according to another effect, with accidentally casual effect of helping of appearance of disease) which contributes coherence and consistence of contagion and man who can get disease - what will result with binary 'causative link'; while the following cause is important b) the appearance of disease: pathogenic of contagion will reflect only after previous appearance of permanent 'immanent causative link'. Reconstitution of epidemic is final act, recapitulation of familiar natural happening of concrete epidemic with anterograde chronology how the event itself happened.

Anxiety disorders are very common illnesses that are reported in approximately one third to one quarter of the entire population during the lifetime. Many anxiety disorders are being reported early in life, they have chronic progress, and cause significant difficulties, interfere in daily life activities and create huge economical expenses. It has been evaluated that 46.6 billion dollars out of 147.8 billion dollars overall mental disorders expenses in US is being spent on anxiety disorders, while in European community those expenses exceed 41 billion Euros. In spite of that, pharmacoeconomical aspects of these illnesses so far drawn much less attention than so called large mental illnesses (schizophrenia, depression), and the reason for that is probably that earlier relatively cheep benzodiazepines were dominantly used in treating anxiety disorders. However, in newer times the anti-depressives became the first choice for anxiety disorders, especially those from the group of selective serotonin reuptake inhibitors (SSRI). The increase of anxiety disorders prevalence and changes in modern pharmacotherapy create promising research conditions for starting the studies in area of pharmacoeconomics in the world, and in our country

Drugs prescription and drugs accessibility are among the most important drug use related topics. A patients questionnaire was conducted in the area of Novi Sad, Bačka Palanka, Bač, Temerin and Odžak (all in South Bačka region), because the routine medical statistics does not provide all neccessary data about the drugs availability. It is demonstrated that pressure and expectations of patients and doctor-patient relationship influence the choice of drugs to be prescribed. Positive list drugs deficiency represent a great problem, forcing patients to buy drugs in private-owned stores or abroad.

Myocarditis is defined, clinically and pathologically, as inflammation of the heart muscle. The autoimmune phase is belived to play a major role and the use immunosuppressive agents may be useful in containing myocyte destruction. Aims was to systematically review the impact of Immunomodulative therapy on the outcame of severe and acute myocarditis in children. We retrospectively studied all the children admitted to University Children s Hospital with an acute viral myocarditis (AVM) from 2003-2008y. Patients were included if they had 1.severe and acute heart failure, 2 left ventricular dysfunction assessed by echocardiography, 3. a recent history of viralillness and 4. absens of personal or familial history of cardiomyopthy. Fourteen patient (37%) had severe and acute myocaditys. Seven patients were treated with immunomodulative therapy and anticongestive therapy (group I). Other seven patients were treated with anticongestive therapi only (group II). We comparred the use of antikongestiv therapy alone, with a combination of immunomodulative. Such studies have documented succeful outcome of AVM with immunomodulative trearment.