Diabetic retinopathy, particularly diabetic maculopathy, are leading cause of visual loss in the world.Purpose: to estimate type of diabetic maculopathy in patients with diabetic retinopathy. Method: hospital based study. 118 patients with diabetic retinopathy underwent complete ophthalmologic examination ( mean age 58,1 years, male 78, female 40; 7% were diabetes type 1 patients; 46% had nonproliferative diabetic retinopathy (NPDR) and 54% had proliferative diabetic retinopathy (PDR). Results: 88 patients (74% of all) had diabetic maculopathy. The most common type of diabetic maculopathy was diffuse (60% of all patients ), afterward focal (33% patients) ischemic maculopathy (both with PDR) had two patients (3%) and five patients had mixtus (7%) . Conclusions: diffuse diabetic maculopathy is the most common type of maculopathy both in NPDR and PDR

Authors analyse radiological characteristics of different forms of osteomyelitis in the period from 1990. to 1994. on Ortopedic and infective Clinic of Clinical hospital Centre in Pristina. Clinical picture of unspecific osteomyelitis of different forms, tubercular and brucellosis osteomyelitis is presented radiolography, tomography, myelography, fistulography, arteriography, scintigraphy, and computerized tomography. Radiological changes of osteomyelitis of different etiology and clinical picture are presented in detail

In two refugee camps, near K.Mitrovica (in little colliery city), gipsys refugees dislodge by Albanians were temporary located. In their blood, lead contamination is discovered. All together 310 children, 1-14 years old, were contaminated by lead. Examination and treatment is implement by the SZO patronage, which took capillar blood samples from 298 children and vein blood samples from 190 children. Level of lead, in 47 cases was more then 45 microgram./dl. All the children with high level of lead had physical and laboratory tests. Also, they were under special food diet, with a lot of calcium. In 45 cases, per os treatment is used with “Chemet” medication, produced by McNeil-USA.Only in 9 cases, week bad reaction was notice using this medication. In some isolated cases, headache, pain in stomach, sickness and sleepiness. This difficulties didn't required therapy cancelation. Treatment was fully successful except in two cases, where therapy was repeated.

Nitric oxide (NO) is a major messenger molecule that plays key roles in many physiological processes. NO is produced by nitric oxide synthase (NOS), which catalyzes the conversion of L-arginine to L-citruline and NO. At least three isoforms of NOS have been identified and characterized, namely, neuronal NOS (nNOS), endothelial NOS (eNOS) and inducible NOS (iNOS). Recent evidence indicates that most of the cytotoxicity attributed to NO is rather due to peroxynytrite, produced from the diffusion controlled reaction betwen NO and another free radical, the suproxide anion. Peroxynitrite interacts with protein, DNAand lipids via direct oxidative reactions or via indirect radical mediated mechanisms

Search for objective indicators of health state of the population is essential public health issue. First serious attempt of health evaluation of the population were observed in the end of 18. and beginning of the 19. century. In this period of time, description of health population was mostly based on indicators which were based on data of numbers of death. Later, because of significant decrease of infectious disease and improvement of life and work conditions comes to an extension of average life span. Also, comes to a change of conceptualization of health. As a result of all this changes it has been noticed need for consideration of other aspects of health. As a outcome, indicators of disease, disability and non-biological indicators of health (as a approach to health service, quality of health protection, condition of living, life style factors and environment factors) are more and more necessary for documentation of human capacity for physical, mental and social functioning as a objective analysis of health state. To get all the information of all aspects of health which can not be get from health statistics routine data, was started with examination of population health trough interview, respectively polling out representative population sample. Aim of this studies is to get basic information about population health, in manner to supplement the picture of population states, identify health problems and health needs, to get the picture of representations of risk factors among population; to get the picture of health service utility; to find out health disparity among different countries and inside the country, among different population groups; to follow the change of health states during the time; to follow achievement in health strategy; to insure data for people which are creating health politics, in manner to coordinate theirs politics, strategy and programs. This kind of study is taking place every year in many countries and in others periodically. In our country this kind of studies were done during the year of 2000. and 2006

Rituximab is a human/mouse chimeric IgG1 monoclonal antibody that specifically targets the CD20 surface antigen expressed on the cell surface of all preplasma cell stages of B-cell differentiation. By binding to CD20, rituximab causes selective B-cell depletion through antibody-dependent and complement-dependent cell lysis and apoptosis. B-cell depletion is believed to disrupt the many B-cell functions that contribute to the pathogenesis of RA. The purpose of this study was to examine the efficacy and safety of RTX an anti-CD20 B cell depleting monoclonal antibody in combination with methotrexate (MTX),in patients with rheumatoid arthritis who experienced an inadequate response to one or more TNF antagonists and had active disease despite ongoing treatment with MTX and a TNF inhibitor. ACR responses in RTX treated patients were superior to placebo. The primary end point was the proportion of patients in each group that achieved an ACR20 response at Week 24. Secondary endpoints included ACR50 and ACR70 responses, changes in Disease Activity Score (DAS28), and EULAR response

After restoration of approximative cavities where gingive wall is forming subgingivaly occurs an damage of epitel of gingival sulcus and subepitel fibrous tissue. These damages occur partially in order of direct irritative effect of materials, and partially because of inadequately made definite reisen. Anomaly which may occur while making reisen, is effect of micro leakage between reisen wall of cavities roughness and reisen parts which prominate above anatomic tooth sphere , enable faster and bigger accumulating of dental plaque. Gingive inflammation is widening deeper in parodontium trough vascular network situated in interdental bone septum. Inflammation is constantly spreading from the point and reaches parodontium. The aim of this study is to estimate clinical changes in parodontium within certain group of patients of different age and sex, caused by inadequate dental restoration. Results of this research present that anomaly in dental reisen , have great influence on inflammation reaction of parodontium. Composite reisen cause higher degree of inflammatory reaction in compared to amalgam reisen

The tibial and femoral shaft fractures representing prototyp in orthopedic traumatology and great problem for resolving. The speed of limb recovering functionality after surgery is important, and often desicisive for result of treatment. Place of external fixation (EF) in surgical treatment of femurs in DCOS (damage control orthopedic surgery), cominutions of femoral shaft and open fractures, rarely as definitive method. EF in treatment of tibial shaft fractures today take a place as a definitive method like intramedulary nailing. On department of orthopedic surgery in HC Kosovska Mitrovica we examined quality of life and speed of lower limb recovering functionality on 70 patients treated with EF tip Mitkovic as a definitive curative method. The time of achieving early function of lower limbs we divided on 4 levels, and writed time when patients achieved level 3 and 4. Also this timing we compared with middle time of healing tibial or femoral shaft fractures (golden standard) .We examined quality of life with EuroQol 5D evaluation system. 90% of our patient in period 8 to 12 weeks achieved level 3 and 4. There statisticaly significant diference between examined gropu and golden standard, p<0,05. We concluded that EF tip Mitkovic as definiyive curative method improved the speed of lower limbs recovering functionality. Quality of life is very high, 84 points. The number of complications where expected and in proportion with literatures data.

Prepathogenesis of mass occurrence of disease as a complex happening is hiding the “screen”. Social influence remained hidden inside school «25. may», which had as a consequence shown higher distribution of manifested disease. As the main point at performance of events is scientism based on “black box system”. There is uncritical trust in paradigm, statistic methodology there comes “parroting”. Sheltered by screen content of the events, between the enter of the first (sub)system and exit of the final (sub)system the most critical maintain “mixed approach”, with the aim to reveal into the real dynamics by “natural happening of mass disease”, into “driving force” that is causes of self moving - spontaneous genesis of epidemics: a) for mass effects of it is 'natural work' (appropriate according to another effect, with accidentally casual effect of helping of appearance of disease) which contributes coherence and consistence of contagion and man who can get disease - what will result with binary 'causative link'; while the following cause is important b) the appearance of disease: pathogenic of contagion will reflect only after previous appearance of permanent 'immanent causative link'. Reconstitution of epidemic is final act, recapitulation of familiar natural happening of concrete epidemic with anterograde chronology how the event itself happened.

The biggest Serbian medival hospital had founded Stefan Urosh III Nemanjich in the monastery named Dechani. In 1340, it had been founded the hospital of the emperors Dushan in monastery of St.Arhangel near tawn Prizren. By liberation of the province Kosovo and Metohija from the Turkish rule and by united with Serbia,the health had been diveloping in this region. In 1922, it had been founded the state hospital in 1931. Governor, and in 1938, this hospital had the 120 beds and three laboratory rooms for analyses of blood and of urine. In 1924, it had been formed the first bacterologist station in Prizren. In 1928, it had been formed the State childrens home which is in 1929. had been become public health station with the general school ambulanta first aid station,bathroom and laboratory. In 1927. it had been working the Polyclinic in Prishtina were theyhad been carrying on the laboratory analyses.In these health resorts in the province of Kosovo and Metohija have been carrying on the analyses of blood, urine and of bowel as and the microscopy of preparation to malaria and it has been carrying on the education of skilled workers for these analyses. After the Second World war it had been carrying on the education of laboratory technians it the courses and by opening of laboratories in hospitals and health stations in Kosovo and Metohija the specialization of medicine biochemistry have been ending a lot of pharmacists who give a famous contribution to the development of biochemistry in this territory.