Myeloperoxidase (MPO), a heme enzyme present in the primary granules of polymorphonuclear leukocytes (PMNs) participate in oxygen-dependent microbicidal activity of these cells. During the course of bacterial meningitis plenty of PMNs leave blood vessels and migrate to cerebrospinal fluid (CSF) space, and some of their MPO may become, extracellular. MPO activity in control CSF is low (Me = 0.5 U/L), comparing with patients CSF samples of all three groups of proteinorrachia where elevated values were found already on admission (3.5 U/L, 5.0 U/L and 12.0 U/L, respectively), with highest values found during second lumbal punction (5.5 U/L, 7.5 U/L and 14.0 U/L, respectively). Poor correlation was found between albumin quotient and MPO activity CSF/serum, but significant correlation between MPO in CSF and CSF PMNs count.

Apart from great frequency of epithelian, especially preinvasive changes, some very rear diseases common for other lower parts of genital tract (cervix and vulva), are vaginal epithelian changes and especially vaginal intraepithelial neoplasia (VAIN). That's the reason why we don't usually think about this disease, which can have very serious consequences, especially in late discovering of changes in the stadium of invasive malign disease.The aim of this work was to diagnose all pathological changes on vagina: benign, premalign and malign, according to the age of female patients. Biopsy and operative material taken from 1331 female patients treated in Ginecology and Obstetrics Clinic “Narodni front” in Belgrade, were used in this study. The most diagnosed benign changes was condylomata acuminate (42%). Out of 20 cases of premalign changes, VAIN I was diagnosed in 5 cases (25%) as a slight degree of premalign changes, while VAIN II and VAIN III were diagnosed in 5 cases as a severe degree of premalign lesions. Out of 11 cases, there were 3 cases (27.27%) of invasive planocellar vagina carcinoma with histological degree G1N1. 8 cases (72.72%) were with histological degree G2N2, while there were not a single case with histological degree G3N3. Planocellar vagina carcinoma is the most common in the age of 41-50.

Identification of victims during war and post war conflicts means for The Republic of Serbia the most important professional, scientific and ethical investigation. Before the process of identification forensics do the exhumation, very important part of process of which depends successful identification. On the Kosovo and Metohija, from 2001 till 2004. forensics did exhumation in some massive graves and in many single graves. Experiences of experts proove that the process of exhumation is very important becouse in that first phase collecting of evidence through forensic investigations have made “disappeared” victims “visible”, empowered survivors, corrected the historical records, and exposed cover-ups. Through forensic investigations including the identification of all injuries on the dead bodies, we faced with the marks and circumstances which followed the death under existing conditions on Kosovo and Metohija. Forensics promotes democratization and rule of law.

Oral isotretinoin is highly effective in treatment of patients with severe acne, but has been concerned with causing occasional depression. Clinicians should be alert to the high prevalence of depression among people with acne. Isotretinoin has many unwanted effects, among which possible unproven effects on mood have to be included. If depression or other mood change occurs, then isotretinoin treatment should be discontinued. If treatment is continued, psychiatric support should be obtained.

Inhibins are glycoprotein hormones of which there are two molecular forms, inhibin A and inhibin B. Classically, inhibin is known to have a negative feedback effect on pituitary follicle-stimulating hormone secretion. The fetoplacental unit produced inhibin throughout pregnancy. Inhibin Ais the predominant molecular form of inhibin in maternal circulation from 4 week of gestation. Although the precise biological function of inhibin Ain pregnancy is unclear, it is evident from recent studies that inhibin A could be a better marker of placental function than human chorionic gonadotropin because of its shorter half-life. The possible clinical application for the measurement of inhibin Ain early pregnancy could be in predicting miscarriage , Down's syndrome, preeclampsia and fetal growth restriction in the first and/or second trimester before the onset of yhe clinical symptoms. Inaddition, several evidences underline the potential role and the clinical usefulness of their measurements in the diagnosis, prevention,prognosis and follow-up of different gestational pathologies such as:threatened abortion, placental tumors, hypertensive disorders of pregnancy,intrautherine growth restriction,fetal hypoxia.The measurement of inhibin Aand activin Ainto the biological fluids of pregnancy will offer in the future further possibilities in early diagnosis,prediction and monitoring pregnancy diseases.

L-carnitine is assorted with non-vitamin nutritives (metavitamines) on the grounds of importance to the living process, while itb similar to aminoacids in terms of structure. It has multistructural role in functioning of an organism while one of the most important and best investigated roles is the sphere of energizing metabolism because it is needed for the transport of the longchain fatty acids into the mitochondria where they are subject to a β oxidation. It has widespread clinical application in prevention and therapy of: genetic and secondarycarnithine deficiency, cardiovascular disease, lipid metabolism disorder, carbohydrate metabolism disorder, aciduria of organic acids, renal and liver insuficiency, neuropathy, miopathy, as well as the means for improvent of fitness capacites of sportsmen. L-carnitine is crucial part of organism of mamals, therefore it can be applied in relatively big doses whereby it requires no detoxication in liver, on the contrary, it significaty increases its detoxication capacites. Key words: L-carnitine, Physiology, Prevention , Therapy. L-carnitine is assorted with non-vitamin nutritives (metavitamines) on the grounds of importance to the living process, while itb similar to aminoacids in terms of structure. It has multistructural role in functioning of an organism while one of the most important and best investigated rol condarycarnithine deficiency, cardiovascular disease, lipid metabolism disorder, carbohydrate metabolism disorder, aciduria of organic acids, renal and liver insuficiency, neuropathy, miopathy, as well as the means for improvent of fitness capacites of sportsmen. L-carnitine is crucial part of organism of mamals, therefore it can be applied in relatively big doses whereby it requires no detoxication in liver, on the contrary, it significaty increases its detoxication capacites.

Aim of this study was to determine characteristics and correlation between basic anthropometric and spirometric parameters in athletes of different sports and non sportsmen. Measurements were conducted on 140 male and female athletes: volleyball, basketball, soccer, handball players, runners, VESLACI and 60 non sportsmen, 30 female and 30 male. All measurements were conducted in the Laboratory for functional diagnostics at the Department of Physiology, Medical School, Novi Sad. BMI values were normal for all athletes except in handball players, whose average BMI was 25.70+/-2.35 2 kg/m . Average values of body fat percent (BF %) were significantly higher in female athletes, the lowest values were measured in female runners (determined by both methods anthropometry, bioimpedance), while in the group of male athletes the highest body fat was found in basketball players. Statisticaly significant gender difference was found for all anthropometric parameters. Athletes have significantly lower values of BMI and BF% compared to non sportsmen, and males compared to females. Those gender differences are the result of sex determined diferences in body fat distribution, and different length of sports activities. BMI is not a good predictor of body fat content in athletes, because it's high values indicates masculinity rather than fatness. Spirometric parameters show significantly higher values in athletes of both sexes, because ventilatory function is expected as an effect of chronic adaptation on training. Correlation differences between anthropometric and spirometric parameters can be explained by the age differences in our participants and the length of their sports activities.

The fractures of the tibia are mainly the fractures of the long bones. In the department of the orthopedic in Kosovska Mitrovica, 45 of patient with fracture of the lower leg had been treated with using the closed method. It had been the linear fractures in the 84% of the treated cases.The most number of the patients were treated in the hospital for 5 days. In our healing we are noticed the folowed complications in the treated patients: the major infections around the pin were in the 4% of the treated patients (2 patients),the fat embolism were in the 2% of the treated patients (1 patient),the pseudoarthrosis were in the 4% of the treated patients (2 patients). Aplication the extrafocal fixat r by Mitkovich using the closed method made possible that the fracture became stable in fast and simply way with the minnor invasion at the soft tissues and with this are made the conditions for splicing of the fractures.

The aim of this study was to identify main epidemiological risk factors for the Leptospirosis at territory of Serbia. The cross sectional study was used as epidemiological method during investigation. During period of 2000-2006. Leptospirosis affected 211 people, while 14 of them died as a consequence of this illness in Serbia. Number of patients with Leptospirosis was almost equal at the territory of Central Serbia and Vojvodina region, while at Serbian enclaves in Kosovo and Metohija there was no single case of sickness. Most of the affected patients were working people, males between 20 and 60 years old (97%) with higher risk factor for contamination with disease determined by their profession (farmers, fishermen, veterinarians. Seasonal character of illness (most of the affected in August) was caused by increased exposition to Leptospirosis in summer time (swallowing of contaminated water during swimming and diving, small wounds on skin etc)

Breast cancer is mostfreqency malignant tumor in womans, cardinal causer of death in malignant tumots with continous ascendig of incidence and mortality. Actual therapy of breast cancer is multidisclipinary to consist in surgical, irradiant, cytostatic, hormonal and imunological therapy with specific directive based in disease stage. Surgical therapy is now more effectiveness metod of therapy and base of multidisclipinary therapy. In aim of prognosis desease conclusion and risk ratio of local relapse in currency is prognostic factors. With combination a few factors derive prognostic indexes with whose can acquire more information aggainst biologic behaviour of each neoplasm.