Exudative age-related macular degeneration is leading cause of irreversible vision loss in developed countries. Subfoveal localisation of choroidal neovascular membrane is the most difficult form for treatment. At the last three years, the new group of agens well-known as anti-VEGF agens was approved for treatment of exudative AMD. In that purpose, intravitreally administrated agens is recommended. Efficacy and safety of anti-VEGF agens were proved in short-time follow up period.

Chronic vein insufficiency (CVI) is abnormal functioning of a system of veins resulted from incompetence of vein valves, with or without vein obstruction covering both surface and deep veins. Nowadays there are various standars in the diagnosis of CVI and variations of treatment modalities, which increases the importance of occuracy and foundations of the diagnosis. In the consideration of diagnostic needs of patients with CVI, CEAP classification is suggested. This classification defines clinic categories, etiology of problem, covered anatomical segments and pathological mechanisms of CVI.

+Gz acceleration is unique dynamic stress to organism. Development of this occurrence depends not only to magnitude of acceleration but to onset rate and duration too. The most of former researches pointed to +Gz stress as significant stress to basic physiological mechanisms like cardiovascular and respiratory system. The new study was to examine responses of neuroendocrine and immune system to +Gz stress.

Strenuous exercises greatly increase oxygen consumption in the whole body, especially in skeletal muscles. Large part of oxygen consumption by the body is reduced to H O and ATP, but smaller part (2-5%) of these tremendious increase 2 oxygen consumption results in an increased leakage of electrons from the mitochondrial respiratory chain, forming various reactive oxygen species-ROS (O ˙ˉ, H O i OH˙). TheseROS are capable of triggering a chain of damaging biochemical and 2 2 2 physiological reactions such as oxidative stress and lipid peroxidatio. There is a groving number of informaztions pointing on important role of free radicals as mediators in inflamation and damage of skeletal muscles after strenuous exercise. The mechanism of exercise induced oxidative stress are not well understood. The mitochondrial electron transport chain, polymorphneutrophil and xanthine oxidase have been identified as major source of intracellular free radical generation during and after exercise. Also the interaction of metmyoglobin and methaemoglobin with peroxides may be also an importante source of oxidative stress during exercise.

Oral isotretinoin is highly effective in treatment of patients with severe acne, but has been concerned with causing occasional depression. Clinicians should be alert to the high prevalence of depression among people with acne. Isotretinoin has many unwanted effects, among which possible unproven effects on mood have to be included. If depression or other mood change occurs, then isotretinoin treatment should be discontinued. If treatment is continued, psychiatric support should be obtained.

Its analyzed from a epidemic figurante aspect. The childrens department, health headquarters from Kosovska Mitrovica in the year of 2007. They were able to bring 748 children for healing. Down North Kosovo, they had 81% of children and another 7% from the village Priluzje and Plementina come. There was a increase in the number of incoming children in January and Febuary. And then the same time, in september and October. Half of the healed childrens age varies up to 2 years old. In a period of 6 days, they are able to heal 72, 6% of children. In the 94 stuctured diagnosises, they were able to show all the morbidity. Dominating sickness of the respitory system, in the winter season. And the digestive system in the fall season.

Aim of this study was to identify the most relevant epidemiological risk factors for acquiring tularemia. Method used in the study was cross section. During period 2000-2006 at the territory of Serbia (excluding Kosovo and Metohia region) 254 tularemia cases were identified. No lethal outcomes were noted. Tularemia was registered in 11 districts of Central Serbia, while no cases of the disease were noticed in region of Vojvodina. In Serbian enclaves in Kosovo and Metohia there were 4 cases of Tularemia. 4 epidemics with 21 diseased persons were reported at territory of Central Serbia. Majority of patients were 20-60 years old (86%). No significance difference in sex distribution was observed. Almost the same number of male (129) and female (125) patients was affected. This could be explained by identical exposure of both sexes to diseases causative agents. The disease has seasonal character. It occurs most often in late autumn and winter due to contact with diseased rabbits during hunting season, meat consummation, and inhalation of dust containing diseased animal excreta. During observation period linear trend of incidence rate have not shown statistically significant elevation neither decrease.

We have been analyzing a number of patients with cerebral-vascular insult in a period of 1998-2003 year, clinical picture in the time of the reception, the development of the illness, the result and the therapy access in the Neuropsychiatric Department of Health Center in Kosovska Mitrovica. It is concluded that the number of CVI is significantly higher after the NATO bombing, the development of the illness more difficult and a detailed analyses of the causes is in progress. In a period of 01. 01. 1998 until 31. 12. 2003. year, 1829 of patients have been on hospital treatment and 252 of them have been treated from CVI, in the Neuropsychiatric Department of Health in Kosovska Mitrovica. During clinical prospective, retrospective and static research in has been concluded that:in the above mentioned period the number of CVI patients have been increasing in regard to the total number of treated patients in Neuropsychiatric Department of Health Center in Kosovska Mitrovica. The percentage of CVI relapse is increasing(the highest percentage is in 1999). It has been established that besides the well known causes for the occurrence of CVI such as:hypertension, the heart disease, disorders of heart rhythm, endocrine disease(Diabetes mellitus) end also the well known factors of risk for causing of mentioned diseases(corpulence, raised value oh cholesterol in blood, smoking, insufficient physical activity, excessive consuming of alcohol etc). Relevant factor for the occurrence of CVI is the factor of stress, social and territorial isolation of the Serbian population immediate after NATO bombing on the territory of Kosovo and Metohija.

Rheumatoid arthritis is a complex disease, which produces articular symptoms and damage, leading to disability. The aim of the study was the estimate frequency comorbidity, functional ability of patients with rheumatoid arthritis.This study included 60 patients (48 female and 12 male) with rheumatoid arthritis, mean age 53,92±7,06. Anatomical stage and functional class were analyzed according to Steinbrocker`s criteria. Functional disability was perfo-rmed using health assessment questionnaire (HAQ) score. Comorbidity was observed in 36 (60%) of patients (33 female and 3 male). Hypertension were found in 19 (31,67%) of patients, whereas 8 (13,33%) of patients had diabetes. It was established that 7(11,67%) of patients suffered osteoarthritis. The median HAQ score was 1,25±0,70. Poorer functional status was observed in 40% of the patients with comorbidity (HAQ score ≥2), than in the group of patients without comorbidity (21,67 %). The results of the study are showing large frequency coexisting disease in patients with rheumatoid arthritis. The frequency of hypertension and diabetes was greater comparing to general population. The patients with rheumatoid arthritis show harder anatomical stage and comorbidity and greater functional disability, as compared to the patients without coexisting disease.

Prostatic intraepithelial neoplasia (PIN) is putative premalignant lesions of the prostate. This lesion has role as precuror of prostatic carcinoma (PC), predictive role for PC and high coexistens with PC. Existed two grade of PIN: low grade PIN (LGPIN) and high grade PIN (HGPIN). PC is most important malignacy in man and has high mortality in male. The aim of research was to invastigated morphological comparative patterns of HGPIN and PC. We analyzed biopsy material of 299 cases (cs). We used histopathological metods of investigation. We found HGPIN in 42 cs (14.0%) with mean age 66.3 y and PC in 35 cs (11.7%) with mean age 70.7 y. HGPIN was most frequently in the seventh decade of life (54.8%), and PC in the eight decade (45.4%). Four common pattern of HGPIN were identified: tufting (78.6%), micropapillary (72.8%), cribriform (16.6%) and flat (9.5%). In 21 from 35 cs (60%) with PC was coexistent HGPIN. HGPIN we found in the periferial part in the 22 cs. (52.4%) and in the periurthral part of the prostate in the 12 Cs. (28.6%). HGPIN were multicentric in the 22 cs. (52.4%), in the 15 cs. (68.2%) in the periferial part, and in the 7 cs (31.8%) in the periurethral part of the prostate. PC in the 22 cs (62.9%) was localized in the periferial, and in the 7 cs in the periuretral portion of the prostate. PC was multicentric in 28.6%. Important histological patterns for distinction HGPIN i PC are: disruption of basal cell layer, perineural invasion, mitotic figures, multiple nucleoli, collagenous micronodules, infiltrative growth. HGPIN and PC we found in sufficient percentage. Both lesion were most frequently multicentric, periferial localisation and coexistent. Because of that these lesions needed serious clinical and histological investigations for patients.