Topiramate is the new antiepileptic drug, which is related with high efficiency in the reduction seazures, and also whit high prevalention of cognitive adverse events. Purpose of study is to define the relationship between efficiency topiramate in control of epileptic seizure and the apperance of cognitive adverse events. In the prospective stady we followed 40 adult patients with refractory epilepsy, which treatment took place on the Institute of neurology Clinical center of Serbia. The efficacy of treatment was estimated as the ratio of the total number of seizures during the last two months before the introduction of topiramate (on basic antiepileptic therapy) and during the last two months on stable (200mg/day) dose of topiramate.All patients are neuropsychological tested twice. First time before the start of therapy with topiramate, and next time two months after the achieving of stable dose. We used neuropsychological tests for evaluation attention, concentration, visual and verbal memory, speech, executive functions, divergent opinion and visual construction abilities. Patients with good success of topiramate in control of the seizures had worse scores on cognitive measurements than patients in whom topiramate was not demonstrated efficacy in treating epileptic seizures. Our findings indicate that the appearance of cognitive adverse events of topiramate possible in patients with reduction of seizure after the introduction of drug. This suggests that the same mechanism topiramat achieve a positive therapeutic effect and adverse effect on cognition in people with epilepsy.

Asthma is one of the oldest diseases although it's etiopathogenesis has been explained in more details recently. It is very commin in the general population, and especially in children's population. Lately, the rising trend of asthma is the result of the increased exposure of children to unfavourable environmental factors such as air pollutants and "new" allergens in the course of 20 to 30 years. Asthma is multifactorial disease, the interaction of many factors is responsible for its inception and deterioration. Our research included 95 children having allergic asthma and 40 children having nonallergic asthma. All examinees were interviewed by means of epidemiological questionnaire on risk factors. In that way, basic demographic data, data concerning predisposing, causal and contributing risk factors for asthma inception were gathered. The average age of children having allergic asthma was 11.18 years, and the ones having nonallergic asthma were 14.25 years. In regard to gender structure of those having asthma, asthma is more common in the case of male population (65%). The risk for allergic asthma inception is increased by air pollutants, respiratory infections, and increased level of serum IgE. The biggest relative risk is found for the increased levels of serum IgE (OP=5.839), allergy to medicines. Those are variables which increase the risk for allergic asthma inception. The above mentioned variables are predicative factors for atopy inception.

One of leading causes of death in the world is stroke, more often it strikes population under the age of 65, and those who survive it are left with a maximum degree of invalidity. Supratentorial infarcts are the most common form of ACM, occuring as a consequence of blood vessel occlusion, which irrigation zone is above tentorium, and it appears in 80% of infarcts. Diagnosing of such infarcts is based on clinical and neuroradiological parameters, and computed tomografy is called "gold standard". Therefor, our goal was to introduce a CT parameters, which follow complications of supratentorial infarcts and have predictional character. A prospective study followed the state of 60 patients with supratentorial infarcts of brain, performed CT diagnostics, established infarct complication parameters and their effects on clinical state and diseases outcome. Large tentorial infarcts in ACM vascularisation zone, mass-effects and mediosagital structure motions are significant predictors of infarct ill outcome when it comes to surviving and functional recovery. 

Regulatory T cells represent unique CD4+CD25+ population of T lymphocytes, which are involved in many immunological events. These cells have very important role in maintaining peripheral tolerance, prevention of autoimmune diseases, in immunological respond to infection, particularly by intracellular microorganisms as well as in a process of tumorogenesiz. There are two populations of regulatory T cells: natural regulatory T cells - nTregs and adaptive, inducible regulatory - iTregs. They differ between each other in accordance to the place of creation, in accordance to the specificity of the T cell receptor, as well as the action mechanism. nTregs and the other T cells arise in thymus, which provides specific inductive environment for maturation and immunological education of progenitor cells to imunocompetent T cells. iTregs arise on periphery from the conventional CD4+ T cells after stimulation by antigen under the different conditions. There is number of subpopulations of iTregs and the most important are Tr1 and Th3 cells. Tr1 cells produce big amounts of interleukin 10 (IL-10), and they are called IL-10-secretory regulatory cells, whereas Th3 cells are necessary for maintenance of peripheral tolerance to mucous surfaces, through their dominant cytokine TGF-â (transforming growth factor-â) and they are most widely spread in the mucosa of the digestive tract. Previous researches have shown that regulatory T cells achieve their suppressor activity via inhibitory cytokines, cytolysis, and induction of metabolic disorders and modulation of maturation or function of dendritic cells.

Within published data, arthropathies in diabetics, alcoholics, trauma, tabes dorsalis, syringomyelia, and scleroderma are judiciously called neuropathic arthropathies (Vargazon). Main common characteristics of these arthropathies are the following: they involve one or more joints; there is edema, deformity, ulcerations, increased pigmentation and myositis ossificans (Reinhardt, Clouse, Thornhill, et al.). The most common findings in diabetes mellitus are neuroendocrine dystrophies of musculoskeletal system. Diabetic osteoarthropathy is common name that refers to rheumatic diseases that are frequently encountered in diabetics. These diseases include: Charcot joint, hyperostotic spondylosis (Forestier's disease), humeroscapular periarthropathy, Dupuytren's contracture, joint contracture with skin thickening in juvenile diabetes mellitus, etc.

Materials wich use like base,and those used for direct and indirect capping should be, except certain physicalchemical and biological performance have and antibacterial effect, to act after the application on residual microorganisms. The aim of this study is that in vitro display antimicrobial activity of some selected resources that are used to protect the dentin below the permanent restoration, and some of this as medication in treating deep surface carious lesions and to directly cover any caries, either artificially open pulp. Antimicrobial activity was tested against microorganisms. On agar plates into the grooves 4 mm in diameter was inserted freshly prepared paste or base. After inserting the material into the surface of bloî od agar, was performed by incubation under aerobic conditions for 24 h in a thermostat at 37 C. Negative effect on the microorganisms, tested materials, it was estimated by the size of growth inhibition zone.

The aim of the research was to use a system of 25 variables of morphological characteristics on a sample of subjects numbering 200 top athletes, all males (50 handball players,50 volleyball players, 50 basketball players, 50 soccer players), aged 18 to 30, in order to determine their factor structure, which would be in aid of more rational procedures for the continual selection of athletes in these sports and the transformational training process. By means of the component analysis (the direct oblimin) and the GK criterion (ë≥1.00) used to obtain the common characteristic roots and the explained segments of common variance, five latent variables were isolated for the handball players (body mass and voluminosity and the subcutaneous fatty tissue of the upper body, the longitudinal dimension of the skeleton, the subcutaneous fatty tissue of the lower extremities and upper àrm, the transverse dimension of the lower extremities, the transverse dimension of the elbow and shoulder), six latent variables for the volleyball players (the transverse dimension of the wrist and body volume and mass, subcutaneous fatty tissue of trunck, longitudinal dimension of skeleton, the transverse dimension of knee and foot length, lower leg skin folds and fatty tissue of the upper arm,elbow diameter), another five latent variables for basketball players (the longitudinal dimension of the skeleton, body mass and voluminosity and subcutaneous fatty tissue of the trunck, the subcutaneous fatty tissue of the lower extremities and upper arm, transverse dimension of the lower extremities and the wrist, the transverse dimension of pelvis) and six latent variables for the soccer players (the longitudinal dimension of the skeleton, the subcutaneous fatty tissue of the lower extremities and upper arm, body mass and voluminosity, the transverse dimension of the legs, shoulder and hand, the subcutaneous fatty tissue of the trunck, transverse dimension of the arms). On the basis of the identified factor structures of the latent variables, it can be concluded that we are dealing with a case of different morphological structures of the different athletes. 

Basic features of spiral scanners are described, and constructive features of multislace devices are described in detail.Basic principles of functioning and detector number of multislace scanners are described, particularly in 64 layered devices.A short survey of device construction and received X-ray dose during examination is presented. Diagnostic possibilities and multislace scanner application according to organs and organ systems, as well as their advantages in relation to sequential and spiral scanners, are presented.

In this review paper, metabolism of most used inhaled halogenated anesthetics (halothane, enflurane, isoflurane, desulfurane and sevoflurane) is shown Only part of the anesthetics is metabolized, while the remainder is eliminated unchanged. They are metabolized by mixed function oxidases (reductive or oxidative pathways). 

Because of it’s anabolic and lipolytic effects and with the beginnings of the production of recombinant growth hormone for the treatment of many congenital diseases began and growth hormone abuse in sport. His contributions to enhancing the physical performances of athletes are debatable, and there are many side effects. Detection of growth hormone use as doping agents is impossible by standard means of doping because of the identity of its recombinant and natural forms. There are various tests measuring its isoforms and collagen peptide, while the use of carbon isotope is still under investigation. Efficient detection tests, the use of "athlete passport" and education of athletes, are good way to prevent misuse of growth hormone.