Type 2 diabetes represents a progressive disease, primarily characterised by impairment of glycoregulation, despite the application of various therapy modalities. The main problem with type 2 diabetes, is progressive impairment of betacell functioning, and impairment of insulin resistance. There is an ongoing pursuit after adequate therapy modalities aiming at preservation of beta-cell function followed by loss of weight and assurance of good glycoregulation. For mentioned reasons, research has been done recently on the functioning of enteropancreatic axis in type 2 diabetes. It has been noted that oral intake of food or glucose leads to higher increase in secretion of insulin in comparison to the intake of the same quantity of glucose intravenously, resulting in assumption that hormone signals from endocrine cells of intestine released by the intake of food represent potent stimulators of insulin secretion. Such role is played by GLP-1 and GIP, GIT peptide hormons which stimulate secretion of insulin and release themselves into blood when stomach himus penetrates into duodenum, that is before glucose from himus is absorbed into internal body media. Persons with type 2 diabetes have got low level of secreted GLP-1 after meal. Chronic administration of GLP-1 agonists leads to reducing glycemia and HbA1c. The potential of GLP-1 agonists to decelerate progressive decay of beta-cells at diabetics is alluring, but insufficiently documented. DPP-IV inhibitors represent complementary approach for provoking incretin effects, by oral intake of pills.

Helicobacter pylori infection is the largest number of infected people in the world. It is believed that 50 - 60% of world population infected, but with uneven schedule. Helicobacter pylori is the most important cause of duodenal and gastric ulcer. The prevalence of infection in different communities vary depending on geographic, racial and socioeconomic factors, and the last 10-20 years in some areas can be observed a significant reduction in the frequency of infection in both the general population and among patients with peptic ulcer. In our country, except in the territory of Vojvodina, there was no serious investigation of frequency of Helicobacter pylori infection in the general population.

Clinical praxis shows that patients with panic disorder have experienced different stressful life events which could be linked with the onset, development, and maintenance of the disorder. The aim of the study was to analyze the life events occurring one year before the onset of the panic attacks. The research has been conducted on the Psychiatry and Neurology Clinic, Clinical-Hospital Center Pristina, Gracanica. The sample consists of 84 patients with panic disorder. The data were obtained using the Questionary NIMH PQ consisting of 11 stressful life situations and a possibility for the participants to add a life event that was not included in the questionary. The standard descriptive and analytic statistic methods have been applied. The results revealed that a majority of patients (88%) have experienced some stressful life event in the period of one year before the first panic attack. The most common life event was change of life space. The second frequency has loss of job, following with death of a family member, disease, traffic accident, and continuing education moving to a different town. It can be concluded that stressful life events can be significant factors for the onset, development and maintenance of panic disorder. 

Dermatoglyphs are epidermal ridges on the volar surfaces of fingers, toes, palms and soles.Their development begins between 6th and 7th gestational week, so that critical stage of ridge differentiation occurs in the first trimester, coinciding with critical phase of embryonal development. The inheritance of epidermal ridge patterns is polygenic, often markedly affected by some environmental factors causing them to be reffered as multifactorial traits. Genetic determination, time of occurrence, stability and high individuality enable dermatoglyphic analysis to give an insight in critical stage of embryogenesis. Unusual dermatoglyphic variables are found to be significant markers in many numerical and structural chromosomal aberrations .Many investigations have proved epidermal ridges configuration analysis as a powerful additional screening method in identification of congenital anomalies, detection and prevention of different genetically caused disturbances.

Regulatory T cells represent unique CD4+CD25+ population of T lymphocytes, which are involved in many immunological events. These cells have very important role in maintaining peripheral tolerance, prevention of autoimmune diseases, in immunological respond to infection, particularly by intracellular microorganisms as well as in a process of tumorogenesiz. There are two populations of regulatory T cells: natural regulatory T cells - nTregs and adaptive, inducible regulatory - iTregs. They differ between each other in accordance to the place of creation, in accordance to the specificity of the T cell receptor, as well as the action mechanism. nTregs and the other T cells arise in thymus, which provides specific inductive environment for maturation and immunological education of progenitor cells to imunocompetent T cells. iTregs arise on periphery from the conventional CD4+ T cells after stimulation by antigen under the different conditions. There is number of subpopulations of iTregs and the most important are Tr1 and Th3 cells. Tr1 cells produce big amounts of interleukin 10 (IL-10), and they are called IL-10-secretory regulatory cells, whereas Th3 cells are necessary for maintenance of peripheral tolerance to mucous surfaces, through their dominant cytokine TGF-â (transforming growth factor-â) and they are most widely spread in the mucosa of the digestive tract. Previous researches have shown that regulatory T cells achieve their suppressor activity via inhibitory cytokines, cytolysis, and induction of metabolic disorders and modulation of maturation or function of dendritic cells.

Within published data, arthropathies in diabetics, alcoholics, trauma, tabes dorsalis, syringomyelia, and scleroderma are judiciously called neuropathic arthropathies (Vargazon). Main common characteristics of these arthropathies are the following: they involve one or more joints; there is edema, deformity, ulcerations, increased pigmentation and myositis ossificans (Reinhardt, Clouse, Thornhill, et al.). The most common findings in diabetes mellitus are neuroendocrine dystrophies of musculoskeletal system. Diabetic osteoarthropathy is common name that refers to rheumatic diseases that are frequently encountered in diabetics. These diseases include: Charcot joint, hyperostotic spondylosis (Forestier's disease), humeroscapular periarthropathy, Dupuytren's contracture, joint contracture with skin thickening in juvenile diabetes mellitus, etc.

Introduction: Delivery with foetus in breech presentation carries a dilemma for obstetrician concerning the method of choice which would be the best for the foetus and the mother. Goal: The aim of this study was to analyse the frequency of breech presentation, mode of delivery and the methods of manual assistance concerning the Apgar score of the children at delivery. Method: Study involved all women with a child in breech position who gave birth in the Institute for Gynaecology and Obstetrics of the Clinical Centre of Serbia in Belgrade during the period of six years. Results: Frequency of the breech presentation in the investigated period was 4.5%. In the last three years children in breech presentation are delivered more often by caesarean section (2.7-3.1%) than vaginally (1.6-1.7%). In vaginal deliveries manual assistance by Bracht/Lowset was performed most often- in 70.5%. At the second place is manual assistance by Bracht- in 18, 2%. Feet extraction of the foetus is performed in 4.4% of deliveries. The frequency of Smeli-Veit assistance is 6.7%, while the Forceps was used in 0.3% of cases. High Apgar score from 8-10 have foetuses born using the methods of assistance by Bracht/Lowset and Bracht (83 85%) with high statistical significance in comparison with other three methods of manual assistance (p<0.001). There is no statistical significance concerning Apgar score between the methods of Bracht/Lowset and Bracht (p=0.59). Conclusion: By using the adequate manual assistance which is the least traumatic for the foetus we achieve better postnatal prognosis. 

Arrhythmogenic right ventricular dysplasia (ARVD) is a myocardial disease, often familial, that is characterised pathologically by fibrofatty replacement of the right ventricular myocardium, and clinically by ventricular arrhythmias of right ventricular origin which may lead to sudden death, mostly in young people and athletes. The term "dysplasia" was originally used to describe an entity that was considered to be the result of a developmental defect of the right ventricular myocardium.

Degenerative diseases are no inflammatory diseases intervertebrales discus, joints and ligaments vertebrae with subsequent changes in the bony spine structures. Degenerative diseases are very common and lumbar syndrome is most of them common. Because large disability that gives not only a medical but also social and economic problem. Starting of these facts here, work is set purpose,to the overall context of the diagnosis,differential diagnosis of degenerative lumbar sindrom. This is a complex problem that requires a great effort, expertise and modern diagnostic procedures in clinical rheumatology, which is outstanding problem in practice. We hove processed 55 patients with chronic low back pain and 20 patients with chronic low back pain and other etiology. With history, clinical examination, laboratory analysis, Rtg recordings,and other additional analysis (EMG,CT,MRI) that dodge tried to make the diagnosis and successful treatment.

The pseudoarthrosis is a pathological state of the bone when the refracted bone fragments are not connected by bone callus. The causes for the occurrence of the pseudoarthrosis may be general and lokal.In treatment we were using two methods: the bone plastic and osteosynthesis and compression osteosynthesis by Ilizarov. The aim of this work is the analysis of patients with pseudoarthrosis and results of treatment. The study included 29 patients treated for the past ten years the Department of Orthopedics Health Center Z.C.Kosovska Mitrovica.The most frequently pseudoarthrosis were in humerusu 6 (21%), ulna 6 (21%) and skafoidne bone 6 (21%). The pseudoarthrosis in tibia was treated in 4 (14%) patients, in the femur 3 (10%) patients. 2 (7%) of the patients were operated with diagnosis the medial-maleolus pseudoarthrosis of the tibia fractures and 1 (3%) patient were operated with diagnosis the maleolus pseudoarthrosis of the fibula and of the radius.We were using the treatment methods osteoplastic and osteosynthesis for 28 (97%) patients and one patient was treated with the device by Ilizarov method. Patients were monitored by the clinical way, by the radiographic way ,by laboratory way and by the functional way The average time of the monitoring was ten months .The average time of the healing was the five months. We noticed the one complications only, a lesion of the radius, which is repaired. The pseudoarthrosis is not common, in our material it is 4% of the total number of the operated patients.The most frequently pseudoarthrosis was on humerous 21% (6 patients). By applying the compressive osteosynthesis methods and osteoplastic method we have achieved the completely curring in 89% (26 operated patients).