One of leading causes of death in the world is stroke, more often it strikes population under the age of 65, and those who survive it are left with a maximum degree of invalidity. Supratentorial infarcts are the most common form of ACM, occuring as a consequence of blood vessel occlusion, which irrigation zone is above tentorium, and it appears in 80% of infarcts. Diagnosing of such infarcts is based on clinical and neuroradiological parameters, and computed tomografy is called "gold standard". Therefor, our goal was to introduce a CT parameters, which follow complications of supratentorial infarcts and have predictional character. A prospective study followed the state of 60 patients with supratentorial infarcts of brain, performed CT diagnostics, established infarct complication parameters and their effects on clinical state and diseases outcome. Large tentorial infarcts in ACM vascularisation zone, mass-effects and mediosagital structure motions are significant predictors of infarct ill outcome when it comes to surviving and functional recovery. 

Topiramate is the new antiepileptic drug, which is related with high efficiency in the reduction seazures, and also whit high prevalention of cognitive adverse events. Purpose of study is to define the relationship between efficiency topiramate in control of epileptic seizure and the apperance of cognitive adverse events. In the prospective stady we followed 40 adult patients with refractory epilepsy, which treatment took place on the Institute of neurology Clinical center of Serbia. The efficacy of treatment was estimated as the ratio of the total number of seizures during the last two months before the introduction of topiramate (on basic antiepileptic therapy) and during the last two months on stable (200mg/day) dose of topiramate.All patients are neuropsychological tested twice. First time before the start of therapy with topiramate, and next time two months after the achieving of stable dose. We used neuropsychological tests for evaluation attention, concentration, visual and verbal memory, speech, executive functions, divergent opinion and visual construction abilities. Patients with good success of topiramate in control of the seizures had worse scores on cognitive measurements than patients in whom topiramate was not demonstrated efficacy in treating epileptic seizures. Our findings indicate that the appearance of cognitive adverse events of topiramate possible in patients with reduction of seizure after the introduction of drug. This suggests that the same mechanism topiramat achieve a positive therapeutic effect and adverse effect on cognition in people with epilepsy.

Asthma is one of the oldest diseases although it's etiopathogenesis has been explained in more details recently. It is very commin in the general population, and especially in children's population. Lately, the rising trend of asthma is the result of the increased exposure of children to unfavourable environmental factors such as air pollutants and "new" allergens in the course of 20 to 30 years. Asthma is multifactorial disease, the interaction of many factors is responsible for its inception and deterioration. Our research included 95 children having allergic asthma and 40 children having nonallergic asthma. All examinees were interviewed by means of epidemiological questionnaire on risk factors. In that way, basic demographic data, data concerning predisposing, causal and contributing risk factors for asthma inception were gathered. The average age of children having allergic asthma was 11.18 years, and the ones having nonallergic asthma were 14.25 years. In regard to gender structure of those having asthma, asthma is more common in the case of male population (65%). The risk for allergic asthma inception is increased by air pollutants, respiratory infections, and increased level of serum IgE. The biggest relative risk is found for the increased levels of serum IgE (OP=5.839), allergy to medicines. Those are variables which increase the risk for allergic asthma inception. The above mentioned variables are predicative factors for atopy inception.

Tumor budding refers to an isolated cell or a cluster of up to five undifferentiated tumor cells, located in the stroma close to the invasion frontline of a carcinoma. It has been observed that tumor budding invariably precedes both an invasion into the lymphatic vessels surrounding a tumor and the development of metastases in lymphatic nodes. The aim of this paper is to determine the link between tumour budding, lymphatic vessel invasion and presence o lymph node metastasis in colorectal carcinomas. The study involved 92 cases of colon and upper rectum cancers removed at the Trebinje General Hospital and the Medical Centre in Kosovska Mitrovica. High-grade tumour budding was diagnosed in 66 (71.7%) cases, and lowgrade tumour budding in 26 (20.3%) cases. Lymphatic invasion was detected in 63 (68.5%) cases (55 (87.3%) of these cancers showed high-grade tumour budding, while on the other hand 8 (12.7%) had low-grade tumour budding). Lymphonodal metastases were found in 45 (48.9%) cases (of which 36 (80.0%) were high-grade and 9 (20.0%) low-grade incidents). Based on the ÷2-test, it may be concluded that the distribution of tumour budding in relation to lymphatic invasion (p<0.001) is statistically very significant, which was not confirmed in the case of metastases developing in lymphatic nodes (p>0.05). In conclusion, tumour budding is highly linked to lymphatic invasion, which it most probably precedes. 

The objective of this study that included 34 patients with psoriasis was to assess the reliability of the disease severity measures (i.e. Psoriasis Area and Severity Index - PASI) and the reliability of the health related quality of life measures (i.e. EuroQol EQ-5D Quality of Life Scale - EQ-5D, Dermatology Life Quality Index - DLQI and Psoriasis Disability Index -PDI). High interobserver correlation reliability and good test-retest reliability of PASI scores, as well as good test-retest reliability of EQ-5D, DLQI and PDI scores were achieved. Correlation coefficients between the test and retest scores on DLQI and PDI were higher than those on the dimensions and on EQ-VAS in EQ-5D. Disease severity scores given by PASI and the quality of lify scores given by EQ-5D, DLQI and PDI offered the reliable assessment of both the psoriasis severity and the quality of life of the people with psoriasis.

Any kind of ocular lens opacification is well known as cataract. Most cataracts are age-related, so called senile cataract. Cataractogenesis as process involves either pathological and natural aging processes. Chronical oxidative stress is considered as primary factor in age-related cataractogenesis. In this study we measured concentration of lipid hydroperoxides, sulfhydril groups (SH) and entire antioxidative capacity,as well as ocular superoxide dismutase and catalase activity in 11 subjects with diabetes mellitus (DM) type 2 and cataract and in 39 nondiabetic subjects with senile cataract. All patients underwent complete ophthalmological examination before they were surgically treated by phacoemulsifications. 0 During the intervention, aqueous sample in volume 0,2 was aspirated and refrigerated in -20 C and preparated for further biochemical analysis. Parameters of antioxidative power in diabetic subjects with cataract have decreased values (sulfhydril groups and antioxidative potential - FRAP test) in aqueous while one of lipid peroxidation product has increased value (lipid hyperoxide). Aqueous catalase activity in subjects with diabetes and senile cataract is remarkably higher compared with nondiabetic subjects (p<0.0.5). Oxydative stress and antioxidative capacity are well known risk factor in cataractogenesis but in DM 2 patients, oxydative stress is more intensive than in control group.

Chronic pulmonary heart (HPS) stands for presence of right ventricular hypertrophy with or without right ventricular failure, arising as a consequence of chronic bronchial diseases, lung, pulmonary artery, or severe deformation of the thoracic skeleton. Excludes the pulmonary hypertension as a result of heart disease of left cavities, and congenital heart disease. During the evolution of chronic pulmonary heart, distinguished three stages: a) uncomplicated pneumopathology, b) compensated chronic pulmonary heart and c) decompensated chronic pulmonary heart. Lung ventilation is the process of moving air from the external environment to the alveolar and back, and its ultimate aim is alveolar ventilation space. This process takes place through active action - inspirium and passive - expirium, which causes the lungs to the basic position of rest. The disorders of ventilation lung function can be obstructive and restrictive, and there are often mixed forms with predominantly obstructive or predominantly restrictive pulmonary function disorder. These disorders were particularly expressed in patients with chronic decompensated pulmonary heart, what indicates this work. We studied 40 patients and found low values of vital capacity (VC) and forced exspirium volume in the first second (FEV ), with normal values of 1 Tiffeneau index, which speaks to the fact that respondents with decompensated chronic pulmonary heart have mixed ventilation insufficienty, ìainly restricted type heavy degree. 

In the group of 30 patients with infarction in the border areas has found a total of 11 patients with anterior watershed infarcts between the artery cerebri anterior and artery cerebri media, 15 patients with posterior watershed infarcts between the artery cerebri media and artery cerebri posterior, and 4 patients with subcortical watershed infarcts between surface and deep branch artery cerebri media. Supratentorial watershed infarcts in the dominant hemisfere were seen in 21 patients, while in subdominant in 9 patients. Each type of watershed infarcts was characteristic neurologic picture. Results of this study depict to high incidence of aphasic disturbances, which is consistent with the anatomical presentation of the speech affected both the anterior ares cortical stroke in transcortical motor aphasia, and the posterior of transcortical sensory aphasia.

NAION is a stroke of the optic nerve. It is acute ischemic disorder of the optic nerve head, which it runs, irreversible loss of vision. Loss of vision in NAION happens suddenly and without pain, usually in morning hours, after waking up.The existence of normal visual acuity does not exclude NAION. The other eye may be affected in a very wide time interval. Results of this stady indicate the importance of a detailed ophthalmologic examination of persons older population, as well as the importance of early intensive therapy during the first weeks of illness. 

In the region of the thorax there are ten till twelve ganglia (ganglia thoracica); wich are white; triangle and irregular shape; rarely fusiform (spindle-shaped) or round. In the upper part of the thorax; ganglia are located in front of of the neck of ribs (collum costae); and in the middle part they are in front of head of ribs (caput costae). In the lower parts; they are near the vertebral bodies; therefore both of the trunks are slightly convergent. In this part; there are no branches which connected both sides of the sympathetic trunk. Lipofucin is yellow-brown; autofluorescent pigment; accumulated during aging in the lysosome of postmitotic cells; such as neurons.