Stevens-Johnson syndrome (SJS) is a severe, episodic, acute mucocutaneous reaction that is most often elicited by drugs and occasionally by infections. The drugs commonly implicated as the cause of SJS are anticonvulsants, sulfonamides, non-steroidal anti-inflammatory drugs and antibiotics. Carbamazepine has been commonly implicated in SJS. We report a case of SJS-TEN overlap syndrome developing in patient who was prescribed carbamazeine after epileptic attack during radiotherapy for the purpose of treatment Glioblastoma multiforme, patients underlying disease, whose symptomatology deteriorated patients condition.

The aim is to determine pathological -ulcero-erosive changes in the gastroduodenal mucosa (erosions, ulcers, ulcers, ulcer complications, subepithelial hemorrhage, etc.) resulting from the adverse effects of salicylates /ACK/ corticosteroid, imunoodulatora which was prescribed in the treatment of rheumatoid arthritis (RA). The test was performed on 50 patients diagnosed with RA who were on the two-year continuous therapy. When respondents were done gastroscopy and pathological macroscopic changes resulting from the gastroduodenal mucosa as a result of adverse effects of administered drugs verified. After two years of preparations ACK controlled therapy, corticosteroids, imunomodula- sector on mucosa gastroduodenal erosions were found in 81.5% of patients, gastric ulcer in 33%, duodenal ulcer with 18.5% of patients and bleeding in 44.4%.

Dezmoidne ili agresivne fibromatoze pripadaju grupi benignih tumora koje karakteriše lokalno infiltrativan rast i sklonost recidiviranju, a koje ne metastaziraju. Prikazana je žena starosti 46 godina, koja dolazi na pregled zbog recidivantnog tumora prednjeg trbušnog zida, ranije PH verifikovanog kao dezmoidna fibromatoza. Uz tumor prednjeg trbušnog zida dimenzija 14.7x7.0x12.5 cm, CT dijagnostikom otkriven je i tumor veličine 5.8x6.2x8.8 cm u loži ranije odstranjenog desnog bubrega, koji je u bliskoj komunikaciji sa donjom šupljom venom (VCI) i desnom zajedničkom ilijačnom aretrijom (AIC dex.). Kompresija na iste je rezultirala otokom desne noge u cjelosti, koji se povukao nakon ekscizije tumora. Postoperativni tok je protekao uredno.

Class II malocclusion are complex anomalies of the skeletal and dental systems. The aim of this study is that the rengenkefalometrics analysis closer determine the morphological characteristics of this malocclusion. For this study were used 30 patients aged 18-30, previously clinically diagnosed class II, before the planned orthodontic treatment. The results analisis lateral cephalometric radiographs were compared with the 30 patients with class I malocclusion. Analyzed three linear and two angular cranial base dimensions and nine angular and four linear measures from the facial skeleton. The Results show: No statistically significant differensis in cranial base angle (SNBa) and anterior cranial base length (S–N) between class II and control Class I. Angle maxillar prognathism ( SNA) is no signifikant different between class I and Class II but SNB angle were signifikant smaller. The length of maxillary base (A`-SnP) is longer and the length of mandibule (Pg`-MT1/MT) is signifficantly smaller. The gonial angle (ArGo–Me) was smaller with open articular angle (GoArSN). Morphological characteristics of class II malocclusion are , retrognathic and smaller mandibular ligth, normognathic and longer maxilla, open articular angle with vertical tendency of the craniofacial growth pattern.

While different definitions for the diagnosis of metabolic syndrome (MetS) have been proposed, their applicability brings confusion about which criteria should be used in clinical practice. This was an observational cross-sectional study conducted during October 2008. in 3 university hospital centers in the north, midst and south of the Serbia. 1715 patients were recruited from outpatient clinical practice and primary health care offices: 37% males and 63% females, aged 34-80 years. To evaluate the impact of different criteria in discriminating high risk population for coronary artery disease (CAD) we used NCEP-ATP III, AHA/NHLBI and IDF definitions. 21,7% (373) from the patients included in the study sustained CAD. The prevalence of MetS in the CAD group was 84,7%, 86,1% and 82,0%, respectively, compared with 58,3%, 60,6% and 61,2% in the control group (p<0.0001). ROC curves ploted by the probabilities for CAD calculated in the logistic models for each definition (adjusted for age, sex, smoking and educational status) indicated that NCEP-ATP III and NHLBI-AHA definitions had a better predictive accuracy compared with IDF (p=0,006 and p=0,016, respectively). When the waist girth is introduced in NCEP-ATP III and NHLBI-AHA definitions as obligatory, this distinction was lost. The NCEP-ATP III and AHA/NHLBI definition is more suitable for discrimination of MetS diagnosis, than the later proposed IDF definition in the subjects of the given population. Inclusion of waist circumference as obligatory criteria failed to show increase in predictive accuracy for CAD.

Collagen is a major constituent of the gingival extracellular matrix, which crucially affects the histoarchitecture of the gingival tissue. Collagen type I dominates the gingival tissue, while type II, III and IV are present to a lesser extent. Changes in distribution and density occur in the inflamed gingiva. The aim of the study was to examine the organization and density of the collagen in healthy and inflamed gingiva. The material for the study consisted of the gingival biopsies performed in 96 patients aged from 13 to 70 years. The gingival specimens were classified into 4 groups: healthy gingiva, gingivitis, moderate periodontal disease and severe periodontal disease. The samples of the gingival tissues were stained by the method of Van Gieson’s Stain, while the VD of the collagen was measured bz the use of multipurpose testing system M42. In healthy gingival collagen are thick and receptive to color. In gingivitis collagen is mostly preserved structure, but reduced volume; in the periodontitis collagen bundles are reduced, short, thin, disorganized, often fragmented and less susceptibility to color. In healthy gingiva collagen fibers occupy 58.6 ± 5.1% of the volume of lamina propria; in gingivitis significantly lower (44.2 ± 6.2%); in moderate periodontitis 32.7 ± 8.5% and in the progressed periodontitis only 28.7 ± 9.7%. Based on our results, we concluded that in periodontal disease occurs collagenolysis. Quantitative evaluation of gingival collagen volume density may reflect the clinical severity of periodontal disease.

Aging of population leads to limitations in functional abilities and in activities of daily living (ADL) which are the essential elements of independent care of oneself. Limitations in performing these activities result in increasing need for assistance and institutionalizing of the elderly. The aim of this study was to investigate the influence of fear of movement, or kinesiophobia, on ADL in elder institutionalized people with chronic pain. The research included 60 individuals older than 65 suffering from chronic musculoskeletal pain, institutionalized in Gerontoloski Centar Nis. The participants` fear of movement was assesed by Tampa Scale of Kinesiophobia, performing ADL was assesed by Katz index and pain intensity was evaluated by Numerical Rating Scale. We found that a large number of participants had high degree of kinesiophobia (63%), as well as that there is statistically significant negative correlation between the values of Katz index and Tampa Scale (r=-0.583, p<0.01). There is no statistically significant negative correlation between the values of Numerical Rating Scale and Katz index (r=0.139, p<0.289). There is no statistically significant positive correlation between the values of Numerical Rating Scale and Tampa Scale (r=0.215, p=0.098). The research showed that kinesiophobia has influence on ADL in elder institutionalized people with chronic pain. Higher degree of fear of movement corresponds to greater dependence of the participants in performing ADL. Pain intensity influenced neither the fear of movement nor the dependence/independence in performing ADL.

Introduction:Istraživanja pokazuju da svako realizovano samoubistvo prati od 8 do 25 neuspelih pokušaja. Osobe koje su pokušale samoubistvo samotrovanjem najčešće navode da su bile preplavljene osećanjima i mislima koje su im bile nepodnošljive. Želele su da pobegnu iz, za njih u tom trenutku, nepodnošljive situacije, ili su izgubili kontrolu nad sobom. Kod osoba koje su pokušale samoubistvo, trovanje lekovima, želja da zaista umru, da nestanu, javlja se retko. Češće je prisutna potreba da „samo“ odspavaju, odmore se, naprave pauzu. Cilj rada: identifikovati najčešći način pokušaja samoubistva kod oba pola ispitanika i sredstva koja su upotrebljena u cilju izvršenja samoubistva. U našem istraživanju najčešći način pokušaja samoubistva kod oba pola je trovanje lekovima - 91,1%, sečenje vena - 5,4%, skok sa visine – 3,6% ispitanika. Najčešće korišćeni lekovi su anksiolitici - 55,4%, kombinacije različitih lekova - 25,0%, antidepresivi - 8,9% , neuroleptici - 7,1%, lekovi i alkohol - 3,6%. Zaključak: najzastupljeniji način pokušaja samoubistva kod oba pola ispitanika je trovanje lekovima. Od lekova u najvećem procentu korišćeni su anksiolitici a u najmanjem procentu kombinacija alkohola i lekova. Nakon pokušaja samoubistva 90% ispitanika su osećali olakšanje što im pokušaj samoubistva nije uspeo.Kod 86% ispitanika na izbor sredstva u cilju samoubistva uticala je laka dostupnost lekova. Kod 3% ispitanika je bio ponovljeni pokušaj samoubistva i to na isti način, trovanje lekovima.

Introduction: In over of 99% cases of cervical cancer its appearing is preceded by persistent cervical epithelium infection caused by high-risk oncogenic types of human papillomavirus (HPV). The aim of the study was to examine the distribution of high-risk oncogenic HPV types compared to patohistological diagnoses of cervical diseases in women. Materials and methods: The study included 56 women with suspected premalignant and malignant cervical lesions, due to suspected colposcopic and cytological findings (Papanicolaou test). The HPV typing by "in situ" hybridization method on high-risk HPV types 16, 18, 31 and 33 was performed in all patients from cervical smear as well as cervical biopsy. Histological findings of cervical biopsy was a "gold standard" in the analysis of materials. Results: Histologically detected premalignant or malignant changes of the cervix were found at 34 (60.7%) of all 56 examined women: 17 of them had LSIL, 13 of them had HSIL, while 4 had squamous cell carcinoma. A positive HPV test had a 47 (84%) of them with a prove of the presence of one or more types of HPV. The most common type of virus was HPV 16 and it was detected in 27 (48.2%) women, followed by HPV 31 that was detected in 26 (46.4%) women, HPV 18 in 18 (32.1%) of women and HPV 33 in 4 (7.1%) women. The infection caused by oncogenic type HPV16 was significantly more frequent in patients with HSIL and cervical cancer (p<0,001), while the infection caused by oncogenic type HPV 31 was significantly more frequent in patients with LSIL and cervicitis (p=0,003). The distribution of HPV 18 and HPV 33 types was not statistically significantly different in patients with different histological findings (HPV 18, p = 0.41; HPV 33, p = 1.0). Conclusion: Based on our results we can conclude that there is a good correlation of HPV infection with pre-malignant cervical lesions and cervical cancer. The incidence of HPV type 16 infection increased with severity of cervical lesions and it is usually detected high-risk oncogenic type virus in women with severe cervical lesions type like HSIL and cancer are. HPV 31 is the most common high-risk type of HPV of mild type lesions, like LSIL and cervicitis are. We believe that women infected by high-risk oncogenic HPV types, although without histologically diagnose of cervical lesion, should be more frequent controle by colposcopy and cytology (Papanicolaou) test, because of possible disease progression to a more advanced level.

Hypertension represents one of the most significant preventable causes of death worldwide, and accordingly the target group for its prevention and early detection primarily refers to young population. Assessment of prevalence of selected risk factors for the development of hypertension among students, and determination of the existence of differences between genders, defined age groups and included faculties. A cross-sectional study was carried out during 2013., at Faculties of Medical Sciences, University of Belgrade. Respondents completed an questionnaire specially designed for the purpose of this study. Categorical data were analyzed using statistical chi-square test of independence. The study included 600 respondents, mainly female (61.2%), with the mean age of 53.1 ± 17.4 years. More than third of the participants (38,6%) reported the genetic predisposition to development of hypertension. Recorded modifiable risk factors were overweight (22,33%), regular extra salt intake (86,3%) and smoking (32,8%). The results of the study indicate presence of reversible risk factors in the observed population. Designing educational programs on chronic diseases during graduate studies is necessary to keep hypertension from developing at older age and mitigate the number of existing risk factors development.