Hepatitis A is an acute viral disease of the liver caused by the hepatitis A virus (HAV) .In many areas of the world represents a significant epidemiological problem, and the infection is usually transmitted by contact, rarely contaminated water and food. The main objective of the study was to identify the most important epidemiological characteristics of hepatitis A in Serbian areas of Kosovo and Metohija. We used the data of reporting of infectious diseases, reports on infectious diseases (seven-day, month, year) of the Department of Public Health Pristina in Kosovska Mitrovica. In our research we used epidemiological Studies of cross-section (crosssectional). Between 2003-2015. in Kosovo and Metohija (Serbian middle) registered 223 cases of hepatitis A. The average incidence in the reporting period was 11.03 / 10,0000. Analysis of age distribution revealed that the most common incidence in people aged 15-19 years, and the rarest people aged 50-59 years. Hepatitis A occurs throughout the year, showing seasonal variations. Trend of incidence shows a negative trend with a reduction in the number of cases in the territory of Kosovo and Metohija. Based on the results of our study we can conclude that hepatitis A is an important public health and socioeconomic problem. In order to prevent hepatitis A, it is important to continue to improve hygiene and sanitary conditions of life as the best general preventive measures.

Injury of the deltoid ligament as a component of the lateral malleolus fractures is caused by the fact rotational forces during the support. The aim of this research is to examine the functional results of the patient who had undergone suture of the deltoid ligament and osteosynthesis of fracture of the lateral malleolus. In a retrospective study the analysis included a series of 45 patients.The diagnosis of rupture of the deltoid ligament is made based on physical findings islands and tenderness in the region of the deltoid ligament and roentgenographic confirmation width of the medial joint space > 4 mm. There is a high degree of correlation with the 25 (55.55%) patients between excellent functional outcomes of treatment calculated by Gregory[11] score and great roentgenographic findings by Konrath score[12]. The total clinical scores of subjective and objective clinical assessment by Gregory of a sample of patients, characterized by an excellent, even with the 40 (88.89%) patients. In the literature there is no agreement on the method of treatment of the deltoid ligament rupture associated with fractures of the lateral malleolus. Based on theoretical considerations, a number of authors advocate surgical treatment discontinued deltoid ligament. In our series, using suture of the deltoid ligament and osteosynthesis of the lateral malleolus, the best results are obtained with the PAB fracture, lower percentages of excellent results is with the SER fractures. The worst result was obtained with the PER type fracture. Anatomical and functional integrity of all parts of the talocrural joint that allows harmony of movement and stability is achieved with osteosynthesis of lateral malleolus and suture of the deltoid ligament.

The panoramic radiography is the most used diagnostic imaging method in planning impacted lower third molar extractions. However, often panoramic radiography does not provide enough information in treatment planning for performing safely surgical extraction of impacted third molars. CBCT (Cone beam computed tomography) provides more precise information in diagnostic analysis especially for planning surgical procedures where complications can be expected due to close relationship between mandibular canal and lower impacted third molars. The aim of this study is comparative analysis of panoramic radiography and CBCT in evaluating the topographic relationship between mandibular canal and impacted third molars. The study included 50 patients with close relationship between mandibular canal and impacted third molars detected using panoramic radiography. After panoramic radiography analysis CBCT was performed in order to diagnose, plan and prevent complications during the surgical tooth extraction. CBCT examination considered comparative analysis with panoramic radiography, marking, volume rendering and assessment of mandibular canal in buccolingual direction. Out of total patients where suprimposition of mandibular canal and impacted third molar on panoramic radiography was detected, in 32 patients mandibular chanal was localised on lingual side. Mandibular canal was positioned at bucal side in 18 of 50 patients. Results of this research indicate that panoramic radiography can be useful in everyday practice for diagnosis, planning and preparing lower third molar extractions, but in cases where close relationship between mandibular canal and lower third molars is detected CBCT is recommended as more precise radiographic imaging method in order to prevent complications.

Often the only available way of checking the adequacy of HD reaching dry weight after completion of dialysis treatment or monitoring arterial blood pressure. The goal of this paper is to show whether echocardiographic index measuring inspiratory collapse VCI can further assist in assessing the state of hydration of patients on HD. Method: In a study that we conducted on the UDK in Belgrade Centre for HD at 20 toro children on HD (before and after HD) and 20 healthy children, the control group. The M mode echocardiography we measured the diameter of the inferior vena cava (VCI) and calculated the index VCI inspiratory collapse. Also, accompanied by the correlation of these parameters with the dimensions of the left atrium, left ventricular in diastolic and body weight. Results: Children were before HD was significantly higher static diameter VCI and LA diameter compared to the control group (p <0.05). Index is collapsed before the HD was be substantially lower than in the control group (p <0.05). After HD LA diameter was still significantly higher than in the control group (p <0.05). while the other parameters were not statistically be substantially different. Index collapsing VCI differed significantly before and after HD (p <0.05), examining the correlation between VCI and diameter dimensions of the left ventricle during diastole (LVD) found a statistically significant positive correlation between these two parameters in all three groups of measurements (p <0.01). A statistically significant positive linear correlation was found between the VCI diameter and diameter of the left atrium (LA) in all three of measurements (p <0.01). A statistically significant positive linear correlation was found between the diameter of VCI and body weight in children after HD and control groups (p <0.01). CONCLUSION: Index collapsing and VCI in combination with other parameters can further improve the monitoring of the state of hydration and improve the quality of life of patients on hemodialysis.

Parodontopathy is a complex disease of periodontal tissues. The patological changes that occure here are destructive and lead to gradual or progressive periodontium disease and its anatomical and functional desintegration. The aim of the research was to use the PCR method (Polimerase Chain Reaction) to identify the presence and spreading of the oral pathogen Actinobacillus actinomycetemcomitans in subgingival plaque in patients suffering from the agressive parodontopathy and then compare it to qualitative-quantitaive structure of dental plaque in patients suffering from chronic parodontopathy. The study included 70 patients, average age of 45. The identification of microorganisms in subgingival plaque was determined by PCR method. In order to comfirm the diagnosis and determine the extent of destruction of periodontal tissue the standar epidemiological criteria were used: plaque index (Silness-Lӧe), gingival index (Lӧe-Silness), SBI index (Mühleman-Son) and DPP. Extremely high statictical significance of presence of A. actinomycetemcomitans was obtained in patients with agressive parodontopathy. The presence of A. actinomycetemcomitans and P. gingivalis showed the difference in distribution in patients with chronic as well as in patients with agressive pardontopathy. In our sample A.a was detected in a high percentage of younger patients with the diagnosis of agressive parodontopathy. Higher rate of A. actinomycetemcomitans in subgingival plaque has a direct impact on the course of parodontopathy. Its detection may be a useful marker for identifying the icreased risk for developing agressive parodontopathy in patients of younger population.

Parathyroid glands are small endocrine gland in the neck that men secrete parathyroid hormone , or PTH ( PTH) , which together with calcitonin and vitamin - D has a primary role in regulating the concentration of calcium and phosphate in the body. The most common disease of the parathyroid gland presents increased and uncontrolled secretion of PTH , which can be defined as primary hyperparathyroidism, if occurs as a result of enhanced functions of one or more of the parathyroid glands , or secondary hyperparathyroidism, which occurs most often in chronic renal failure or as a result of the deficiency of vitamin D. In our case report we describe a patient with cancer paratioidnih gland , which is a very rare disease and is the rarest malignant endocrine tumor

Standardized staging of tumors takes into account the depth of invasion of the intestinal wall and the presence of local or distant metastases, specifically focusing to precisely estimate length of patient survival. This assessment system does not fully reflect the biological behaviour of cancer individually, ie. tumor aggressiveness and ability of recurrence tumor after medical treatment. Futuremore, cancer at some patients have more aggressive growth than other carcinomas in the same clinical stage, because there are other parameters that determine the biological behaviors of colon cancer, which are not included in the standard classification of determining tumor stage. One of the recent arguments which are due in the spotlight is "tumor budding", which represents one cell or group of up to five non-differentiated tumor cells, which are found in the stroma out of the invasive front line of cancer. There are 92 colon cancer and upper rectum processed, which are collected at General Hospital in Trebinje and Medical Center in Kosovska Mitrovica. The aim is to determine whether there is a correlation between the number of tumor budding and stage of tumors in colorectal cancer. The tumor stage is determined by Astler Coller classification. Investigation, based on χ2-test, leads to the conclusion that there is not a statistical significance in tumor budding distribution in relation to tumor stage according to the Astler Coller classification (p = 0.383; p> 0.05).

Endocardial endothelium (EE) is a barrier which controls the passage of macromolecules and fluids between the blood and the adjacent miocardial interstitium. At the same time it is the place of synthesis of numerous endothelial mediators. Histamine as an inflammation mediator increases the permeability of the endothelium, but also has a positive inotropic and chronotropic effects on the heart through the activation of histamine H1 and H2 receptors. The aim of this study was to determine the importance of the role of endocardial endothelium in the effect of histamine on myocardial contraction in the conditions of histamine receptors blockade. The study was carried out on the samples of the right ventricle of the albino Wistar rats (n = 42, age 8 weeks, body mass 180-200g) presented in two experimental models. The first experimental model presented the right ventricle of the rat heart with an intact endocardial endothelium and the second with the endothelium chemically removed by immersion of the chamber in a 1% solution of Triton X-100. Histamine (1x10-4 mol/l) increases the contraction of the right ventricle of the heart with intact endocardial endothelium but also with the removed endocardial endothelium. The effect of the histamine on the contraction was significantly increased in the absence of endocardial endothelium (p<0.05). H1 receptor antagonist, pyrilamine (1x10-6 mol/l) significantly inhibites the positive inotropic effect of histamine on the heart in both groups, with or without endocardial endothelium. Modulatory role of endocardial endothelium in the effect of histamine after the receptors blockade by pyrilamine is not significant. H2 receptor antagonist, cimetidine (1x10-4 mol/l), blocks the positive inotropic effect of histamine on the heart reagardless of the preservation of the endocardial endothelium. Our results indicate the undoubted importance of the modulatory role of endocardial endothelial in the effect of histamine on myocardial contraction.