It is well known that there is a relationship between the zinc and diabetes, and its antioxidant potential. Based on that, the aim of this paper is to investigate the effects of different doses of zinc (9,2 and 18,4 mg / day) in combination with metformin and glibenclamide, to the total antioxidant status (TAS) and the activity of the enzyme superoxide dismutase (SOD) in experimentally-induced diabetic rabbits. The study was conducted on 24 New Zealand rabbits of both sexes, body weight 2,5 to 3,2 kg. In rabbits, experimental diabetes was induced i.v. injection of alloxan (80 mg / kg body weight). Three weeks after causing diabetes, the animals were divided into two groups: first group was treated oral with metformin, an appropriate dose (120 mg / kg body weight), while the second group of rabbits was treated with a suitable dose of glibenclamide (0,6 mg / kg BW). After the washout period (10 t1/2), the rabbits were treated with metformin and a first dose of zinc (9,2 mg) combination, i.e. glibenclamide and zinc (9,2 mg). After another washout period (10 t1/2) the rabbits were treated with metformin and a second dose of zinc (18,4 mg) combination, i.e. of glibenclamide and zinc (18,4 mg). Blood samples were taken in a specified time interval. The TAS value was significantly increased after administration of metformin, single and in combination with zinc, in doses of 9,2 and 18,4 mg, with respect to the value recorded before their application (p <0.05). Also, it is noted a significantly increased SOD activity after administration of metformin (i.e., glibenclamide), and zinc in combination, in a dose of 18,4 mg (p <0.05). This indicates that zinc and metformin have a significant positive effects on the parameters of antioxidative status, but with glibenclamide this effect did not occur.

Topiramate is a newer drug with a strong antiepileptic potential, but also with adverse effects, especially on cognitive functions. This review deals with the study covering the impact of topiramate on cognition in patients with epilepsy. The most common side effects are included somnolence, psychomotor slowing, difficulty in memory, concentration and attention disorder and problems with speaking. Most studies have shown that a high initial dose, rapid titration and application in polytherapy increase the risk of cognitive impairment after-introduction of topiramate. In addition, depression and early onset of the disease can also contribute to cognitive adverse effects, even at low doses of the drug. Although topiramate indisputably linked to the risk of interference cognitive impairments, some studies suggest their reversibility. This, together with high efficiency antiepileptic obliges researchers to continue searching for the risk factors and mechanisms of cognitive side effects in order to define the profile of patients who would be of maximum benefit of the drug in controlling seizures with absent or acceptable side effects.

Arthritis following dyzentery or urethritis was mentioned before our era and later by many others. In 1818 Benjamin Brodie described 5 patients with typical „ Reiters disease”: urethritis, conjunctivitis, arthritis. Many diagnostic criteria for Reiters disease / reactive arthritis have been proposed for practical purpose the most acceeptable is the folowing one: posturethritic or postenterocolitic arthritis is Reiters disease / reactive arthritis. The findings of Chlamydiy from the synovia or in the synovial fluid of itients with RD suggest that arthritis may be of infective but not of reactive origin.

Gout is a direct consequence of chronic hyperuricaemia, who 's prevalence is following sedentary lifestyle and improper diet dominated by foods rich in purines and non-alcoholic and alcoholic beverages with sweeteners. Since gout is associated with other serious comorbidities is essential that the treatment of this disease would be adequate. The results of numerous studies indicate that the worldwide therapy of gout is insufficient in most patients. There is no doubt that this assessment is true for the treatment of gout in the Republic of Serbia, and the reasons for such an assessment are numerous. The most important reason is related to the choice of drugs, because in Serbia they are only available xanthine oxidase inhibitors, which reduce the formation of uric acid, while drugs that increase the excretion of uric acid- Uricosuric drugs are not registered. Beside uricosurics, in Serbia is not registered neither colhicine, a drug that has a very important role in the prevention of adverse effects of antihyperuricaemia drugs in the first few weeks of treatment.

Introduction: Age-related cataract (senile cataract) is one of the leading causes of preventable blindness in the world. Objective: To determine whether other ocular comorbidities (glaucoma, age related macular degeneration, diabetic retinopathy) affect visual function and quality of life in cataract and pseudophakic patients, and, if possible, to determine which disease has a significant effect. Methods: In this study 202 patients were examinated, regarding of the status of cataract on the second, following eye; the patients were divided into two groups: cataract and pseudophakia. Results: Patients with myopia and capsular glaucoma had significant improvement in average visual acuity (0.87 vs. 0.65) after surgery compared to preoperative results (0.38vs.0.24) (p<0.01). Also, patients with age related macular degeneration and non-proliferative diabetic retinopathy with an average preoperative visual acuity (0.05 vs. 0.05) after surgery have a significant improvement in average visual acuity (0.2 vs.0.2) (p<0.01). Patients with primary open-angle glaucoma have significant improvement in average postoperative visual acuity (0.28) compared to the preoperative results (0.05) (p<0.01), while patients with primary angle closure glaucoma had improvement in postoperative average visual acuity (0.1) compared to the preoperative results (0.05) (p<0.1). Conclusion: Significant improvements in postoperative average visual acuity compared to preoperative results reduce difficulties in vision-related activities thus providing higher quality of life.

Salmonellosis are food-borne toxinfections flowing with the clinical picture of acute enterocolitis, and are caused by non-typhoid salmonella (Salmonella food poisoners). The main objective of the study was to identify the most important epidemiological characteristics of salmonellosis in Serbian areas of Kosovo and Metohija We used the data or reporting of infectious diseases, reports on infectious diseases (seven-day, month, year) of the Public Health Pristina in Kosovska Mitrovica. In our research we used epidemiological Studies of cross-section (cross-sectional) Between 2003-2015.god. Kosovo and Metohija (Serbian middle) registered 250 cases of salmonella. The average incidence in the reporting period was 12.35 / 10,0000. Analysis of age distribution revealed that the most common incidence in people aged 20-29 years, and the rarest people ages 15-19 godina.salmoneloze occur throughout the year showing seasonal variations. The trend in the incidence of salmonellosis is decreasing in the territory of Kosovo and Metohija Based on the results of our study we can conclude that a significant salmonellosis both public health and animal health but also economic problem .Epidemiological situation with regard to salmonella requires intense activity in the field of food safety not only medical services, but also veterinarians and veterinary and sanitary inspection.

Fibroepithelial polyps of the vulva are specific mesenchymal lesions that are commonly found in the vulvovaginal region in reproductive period and in premenopausal females. We present a case of a 36 year old female, who came for examination because of interruption of unwanted pregnancy. During the examination we revealed a large flank mass on the stalk, which started from the right labia. Tumor formation was measuring 165x120x10mm, soft consistency, painfully insensitive to palpation. The tumor was removed by excision, cutting the stem at the base and the material was sent for histopathological examination. Histopathological findings confirmed that this is a fibroepithelial polyp of the vulva.

Anatomy of the female pelvic viscera was investigated before and after the Tension free Vaginal tape (TVT-O). Forty patients were included in the study. Surgery was performed between 2009 and 2012 in Clinic of Urology (Clinical Center Nis) and Department of Urology (Municipal Hospital Prokuplje). Stress Urinary Incontinence (SUI) and anterior vaginal wall prolapse was confirmed in all patients. In all patients with anterior vaginal wall prolapse (grade≥2) both tension free vaginal tape (TVT-O) and anterior vaginal wall repair were performed. Pelvic Organ Prolapse Quantification (POPQ) system was used for the evaluation of prolapse before and after the surgery. Mean age of patients was 61 years. Spinal anesthesia was performed in thirty patients and general anesthesia in 10 patients. Intraoperative blood loss was under 50 ml. There were no bladder, nerve and blood vessels injuries . Thirty eight out of forty patients (95%) were satisfied with the outcome of the surgery. There was a significant correction of prolapse after the surgery. Recurrence of prolapse was found in patients with the high grade prolapse before the surgery, as well as, in patients with the history of previous anterior vaginal repair. Pelvic organ prolapse, congenital or acquired, is supported by the congenital weakness of the pelvic floor.

In care of minimal partial edentulism, ie the lack of a tooth, as an alternative method can be used inlay retained adhesive restorations. The aim of this paper is to present possibilities for the application ceramic systems used for adhesive prosthetic restorations. In the making inlay restorations in the region of the posterior teeth can be applied ceramic system of higher strength which can be veneered with translucent ceramics. With the development of adhesive dentistry, it is possible to establish a strong link between restoration and teeth by means of composite cements and thus ensure sustainability of recovery. The clinical procedure is simple, minimally invasive, and provides a glimpse into a way of making inlay retained fixed restorations.