It is well known that there is a relationship between the zinc and diabetes, and its antioxidant potential. Based on that, the aim of this paper is to investigate the effects of different doses of zinc (9,2 and 18,4 mg / day) in combination with metformin and glibenclamide, to the total antioxidant status (TAS) and the activity of the enzyme superoxide dismutase (SOD) in experimentally-induced diabetic rabbits. The study was conducted on 24 New Zealand rabbits of both sexes, body weight 2,5 to 3,2 kg. In rabbits, experimental diabetes was induced i.v. injection of alloxan (80 mg / kg body weight). Three weeks after causing diabetes, the animals were divided into two groups: first group was treated oral with metformin, an appropriate dose (120 mg / kg body weight), while the second group of rabbits was treated with a suitable dose of glibenclamide (0,6 mg / kg BW). After the washout period (10 t1/2), the rabbits were treated with metformin and a first dose of zinc (9,2 mg) combination, i.e. glibenclamide and zinc (9,2 mg). After another washout period (10 t1/2) the rabbits were treated with metformin and a second dose of zinc (18,4 mg) combination, i.e. of glibenclamide and zinc (18,4 mg). Blood samples were taken in a specified time interval. The TAS value was significantly increased after administration of metformin, single and in combination with zinc, in doses of 9,2 and 18,4 mg, with respect to the value recorded before their application (p <0.05). Also, it is noted a significantly increased SOD activity after administration of metformin (i.e., glibenclamide), and zinc in combination, in a dose of 18,4 mg (p <0.05). This indicates that zinc and metformin have a significant positive effects on the parameters of antioxidative status, but with glibenclamide this effect did not occur.

Topiramate is a newer drug with a strong antiepileptic potential, but also with adverse effects, especially on cognitive functions. This review deals with the study covering the impact of topiramate on cognition in patients with epilepsy. The most common side effects are included somnolence, psychomotor slowing, difficulty in memory, concentration and attention disorder and problems with speaking. Most studies have shown that a high initial dose, rapid titration and application in polytherapy increase the risk of cognitive impairment after-introduction of topiramate. In addition, depression and early onset of the disease can also contribute to cognitive adverse effects, even at low doses of the drug. Although topiramate indisputably linked to the risk of interference cognitive impairments, some studies suggest their reversibility. This, together with high efficiency antiepileptic obliges researchers to continue searching for the risk factors and mechanisms of cognitive side effects in order to define the profile of patients who would be of maximum benefit of the drug in controlling seizures with absent or acceptable side effects.

This case report describes the application of adhesively cemented restorations made out of related, although not identical types of ceramic materials in the treatment of inborn hypodontia of the lateral incisors, as well as the aesthetic imperfections of certain teeth in the whole smile. Considering the minimally invasive approach, and the preservation of natural tooth fibers, the restorations have shown to be acceptable both aesthetically and functionally, and have proven themselves as a safe and comfortable solution for patients.

Determination of preoperative prostate-specific antigen (PSA) value is primary procedure in diagnosis of different pathological prostate changes (prostate cancer-PC, prostatic intraepithelial neoplasia-PIN and benign prostatic hyperplasia-BPH), followed by digital rectal examination and prostate biopsy as gold standard. Disadvantage of high sensitivity and low specificity of PSA testing in diagnosis of PC is a problem in clinical practice. Aim was to determine the diagnostic performance of PSA in diagnosis of PC, PIN and BPH. The study included 100 patients divided into three groups: 70 with PC, 20 with a PIN and 10 with BPH. Patients with PIN and BPH were control group. Preoperative PSA values were determined by Tandem-R, The patients were divided into subgroups by baseline PSA level as follows: 4-10, 11-20, 21-30, 31-40 and> 40. The definitive histopathological diagnosis was made on routine hematoxylineosin slides. The area under the receiver operating characteristic curve (ROC), sensitivity-SE and specificity-SP of each PSA level were evaluated for PC. Preoperative serum PSA levels in patients with PC (median-35.82 ng/ml, min-6 ng/ml, max-960.40 ng/ml) were significantly higher than with PIN (median-9.15 ng/ml, min-3.16 ng/ml, max-27.61 ng/ml) and BPH (median-8.68 ng/ml, min0.80 ng/ml, max-31.20 ng/ml). The best diagnostic characteristics of the PSA are on limit value 10 ng/ml (AUC=0.781, SE=92.9%; SP=63.3%; p<0,0001). PSA is of great help in diagnosis of advanced and initial form of PC. The chance of PC diagnosis was greater than that for other pathological changes when PSA level was higher than 10 ng/ml.

Acute bleeding of the upper gastrointestinal tract is an urgent condition with high morbidity, and a significant mortality despite advanced diagnostics and therapy. The goal is to investigate the determinants of the severity of duodenal peptic ulcer bleeding. The research included 304 patients hospitalized for acute bleeding from the upper part of gastrointestinal tract in a five year period. They had been treated in the Clinical Hospital Center Bežanijska Kosa in Belgrade. The diagnosis was made via gastroduodenoscopy. Out of the 304 patients, 197 (65%) suffered from bleeding peptic ulcer. 144 (73,1%) patients suffered from bleeding duodenal ulcer, most frequently with bulbar localization 124/86 (12%); 78 (62,9%) with a duodenal bulb back wall lesion. 48 (35,1%) of the bleeding duodenal ulcers were in the Forrest Ib stage, in 68 (47,2%) patients the size of the ulcer lesion was between 1,1-2,0 cm. A statistically positive correlation was determined between the duodenal ulcer lesions and the intensity of the bleeding (p<0,005). With 68/79/86,1% patients treated endoscopically, haemostasis was successful, whereas in 13/19,1%, rebleeding was localized in 11/84,6% in the duodenum bulb bask wall.

Salmonellosis are food-borne toxinfections flowing with the clinical picture of acute enterocolitis, and are caused by non-typhoid salmonella (Salmonella food poisoners). The main objective of the study was to identify the most important epidemiological characteristics of salmonellosis in Serbian areas of Kosovo and Metohija We used the data or reporting of infectious diseases, reports on infectious diseases (seven-day, month, year) of the Public Health Pristina in Kosovska Mitrovica. In our research we used epidemiological Studies of cross-section (cross-sectional) Between 2003-2015.god. Kosovo and Metohija (Serbian middle) registered 250 cases of salmonella. The average incidence in the reporting period was 12.35 / 10,0000. Analysis of age distribution revealed that the most common incidence in people aged 20-29 years, and the rarest people ages 15-19 godina.salmoneloze occur throughout the year showing seasonal variations. The trend in the incidence of salmonellosis is decreasing in the territory of Kosovo and Metohija Based on the results of our study we can conclude that a significant salmonellosis both public health and animal health but also economic problem .Epidemiological situation with regard to salmonella requires intense activity in the field of food safety not only medical services, but also veterinarians and veterinary and sanitary inspection.

Introduction: Sapho syndorm is a syndrom characterizing with osteoarticular end dermatologic symptoms. Acronym „SAPHO“ means: S-Sinovitis, A-Acne, H-Hyperostosis, O-Osteytis. SAPHO syndrom has a 50 different names in existing literature. For now, etiology remains unclear, but it belongs to group of seronegative spondylarthropathies. Therapy of SAPHO includes NSAIL, glucocorticosteroids, disease modifying anthireumatic drugs (DMARD), antibiotics, bifosfonatos, and anti TNF - alfa drugs with variable success. Case outline: Pacent P.Z, 47 age, female, comes in the hospital, because of pain in anterior chest, with propagation in right arm, end morning stiffness in sacral part, which passes short after. Also, with recidivant pustules on the palms, bilaterally, which precedes itch. Bone scintigraphy was performed: There is a clear increasing binding of radiopharmacs in projection of strenoclavicular joint, and slightly in both shoulders and both knees. HP: Pustulosis palmoplantaris. We introduced in therapy azithromycin in the dose of 500 mg, two times weekly, for 16 weeks. Patient, one year after, is without relapses of arthritis and skin lesions. Conclusion: This report has goal, to get more knowledge about this rare disease, and to be easier for recognition. Also we want to introduce other physicians, of varying specialities, like orthopaedics, and other surguries, with this disease, not only rheuamatologists, dermatologists, and pediatrics.

Hepatitis A is an acute viral disease of the liver caused by the hepatitis A virus (HAV) .In many areas of the world represents a significant epidemiological problem, and the infection is usually transmitted by contact, rarely contaminated water and food. The main objective of the study was to identify the most important epidemiological characteristics of hepatitis A in Serbian areas of Kosovo and Metohija. We used the data of reporting of infectious diseases, reports on infectious diseases (seven-day, month, year) of the Department of Public Health Pristina in Kosovska Mitrovica. In our research we used epidemiological Studies of cross-section (crosssectional). Between 2003-2015. in Kosovo and Metohija (Serbian middle) registered 223 cases of hepatitis A. The average incidence in the reporting period was 11.03 / 10,0000. Analysis of age distribution revealed that the most common incidence in people aged 15-19 years, and the rarest people aged 50-59 years. Hepatitis A occurs throughout the year, showing seasonal variations. Trend of incidence shows a negative trend with a reduction in the number of cases in the territory of Kosovo and Metohija. Based on the results of our study we can conclude that hepatitis A is an important public health and socioeconomic problem. In order to prevent hepatitis A, it is important to continue to improve hygiene and sanitary conditions of life as the best general preventive measures.