The belief in the inability of neurogenesis, that is the inability to create new neurons after embryonic and early postnatal development of the central nervous system, was rejected in the mid-nineties, when the existence of neurogenesis in restricted areas of CNS adult mammals, including humans, was discovered.Transplantation of stem cells or their derivatives into respective tissues or organs is considered as one of the most promising remedies for many incurable diseases.In this review, we summarized current knowledge and present and future perspectives andchallenges regarding stem cells treatment for Parkinson's and Alzheimer's disease, as the most common age-related neurodegenerative diseases.

Introduction: Psychogenic non-epileptic seizures represent a paroxysmal event followed by a sudden change of behavior, cognition or consciousness, mostly of short duration, which resemble or can be understood as epileptic seizures. They occur in persons without epilepsy and in patients with epilepsy. They are not associated with abnormal EEG discharges because their cause is a psychic disorder. Case report: A 20-year-old patient has been suffering of occasional “morning short-lasting jerking hand movements, staring and fainting” since the age of 14 years. Beside a symptomatic anamnesis for epilepsy and non-specifically changed standard EEG, antiepileptic therapy (valproate and lamotrigine) was introduced. Because of non-response to antiepileptic therapy, the patient was forwarded for further clinical examination involving video EEG telemetry, which indicated that this was a case of psychogenic non-epileptic seizures. A successive withdrawal of antiepileptic drugs was initiated, and also, a psychologist and psychiatrist were included into treatment, which resulted in the reduction of seizures and improvement of the patient's general condition. Conclusion: Psychogenic non-epileptic seizures represent a frequent diagnostic problem requiring team's work, while the video EEG telemetry is the method of choice for diagnosis.

Poremećaj podnošenja proteina kravljeg mleka se javlja kod 2-6% dece, uglavnom u dojenačkoj dobi. Cilj rada je bio da se prikažu iskustva i zapažanja u vezi sa kliničkim simptomima i znacima nepodnošenja proteina kravljeg mleka kod odojčadi. U istraživanje je bilo uključeno 121 odojče kod kojih je nepodnošenje proteina kravljeg mleka dijagnostikovano u uzrastu od petnaest dana do devet meseci. U kliničkoj prezentaciji nepodnošenja proteina kravljeg mleka dominirale su kutane smetnje, koje su utvrđene kod 88 bolesnika (72,72%), potom digestivne smetnje, zabeležene kod 68 odojčeta (56,20%), dok su respiracione tegobe bile najređe (14,87%). Ni kod jednog ispitanika nije zabeležen anafilaktički šok. Rezultati istraživanja pokazuju da u poremećaju podnošenja proteina kravljeg mleka kod odojčadi preovlađuju kutane i kutano-digestivne smetnje, dok su respiracione tegobe relativno retke.

Matične ćelije su nespecijalizovane ćelije organizma u vrlo ranom stadijumu razvića, koje u normalnim uslovima u datom tkivu mogu da se diferenciraju u različite tipove funkcionalno specijalizovanih zrelih ćelija. Mezenhimalne matične ćelije (MSCs) su atraktivni kandidati za kliničku primenu u obnavljanju oštećenih tkiva, pogotovu što se mogu izolovati iz više izvora i umnožavati, a njihova primena ne nosi nikakve etičke probleme. Metode izolacije MSCs iz masnog tkiva zasnivaju se na enzimatskom razlaganju dobijenog materijala. Uslovi kultivacije mezenhimalnih matičnih ćelija su temperatura od 37°C i parcijalni pritisak CO2 5%. MSCs se gaje u medijumu, najčešće u a-MEM medijumu sa 10% ili 20% fetalnim telećim serumom. Pod tim uslovima kultivisanja za 7-14 dana adherisane ćelije formiraju kolonije. MSCs su multipotentne i sposobne da se diferenciraju u uslovima in vitro u mezodermalnom pravcu, stvarajući osteoblaste, hondrocite i adipocite. Međutim, one mogu da se diferenciraju i u ćelije ektodermalnog (npr. neurone) i ćelije endodermalnog porekla (npr. ß-ćelije Langerhansovih ostrvaca pankreasa i hepatocite). U Laboratoriji za matične ćelije Departmana za biomedicinske nauke Državnog univerziteta u Novom Pazaru sprovodi se istraživanje MSCs poreklom iz humanog masnog tkiva. U saradnji sa hirurzima Zdravstvenog centra Novi Pazar, a uz poštovanje normi Etičkog komiteta obe ustanove u periodu od 01.07.2011. do 01.07.2012. godine dobijeno je 22 uzorka potkožnog humanog masnog tkiva od ispitanika starosti od 18 do 65 godina. Od 15 uzoraka uspešno je završen proces izolacije i kultivacije, a od 8 i ciljane mezodermalne diferencijacije.

Ocular contusion followed by hyphema is very common ophthalmologic problem. Aim: to determinate basic epidemiologic characteristics, comorbidity of other ocular findings, as well as complications associated with different grade of hyphema. Method: 55 patients with hyphema and ocular contusion were examinated. Results. Male had hyphema almost four times more often then women (80%:20&); workers (34.5%), afterward pensioners (20%) and pupils (18.2%) were the most often injured. The most frequent causes were the wood (43.6%), stone (10.9%) and vegetable foreign body (9.1%), The first grade of hyphema was demonstrated at 30 patients (54.5%), the second at 16 (29.1%), the third at 6 (10.9%) and the fourth at 3 (5.5%). The most frequent associated ocular findings regarding to segments were the following : haematoma palpebrarum, subconjunctival hemorrhage, erosio corneae and haemophthalmus. Secondary glaucoma was the most common ocular complication and it was finding at one patient with the first stage of hyphema but at all patients with the fourth grade of hyphema. Conclusion: grade of hyphema is directly proportional with a grade of ocular complications and frequency of associated ocular findings.

Malignant tumors of the skin (MTS) are between the most common malignant tumors at human population. Because of their similarities, and more important, their dissimilarities, it is very important to determinate histophologycal type, grading and staging, because they are the most important factors of therapy choise and prognosis. The aim of our work was to examine those parameters, and also to define sex, age and locations distribution, as well as the value of surgical treatment. We analysed biopsy material of Institute of pathology, Medical faculty Priština from 2004-2007. year. We found that squamocellular carcinoma (SCC) and basal cell carcinoma (BCC), and malignant melanoma (MM) were more common at older persons, about 2x more common at male, little bit younger at persons with BCC and MM than SCC. The most common location was skin face; at persons with SCC and BCC significant more common than on all other skin locations. SCC was more common below, and BCC was more common on skin face above imagine line from tragus to the same side lips corner. Average size was about 1,5 cm, and macroscopic they were ulcerous, verrucous and infitrative. Invasive SCC was diagnosed in 2/3 cases in the most early stadium. In opposite MM was diagnosed in late stadium in majority cases. Moderate inflammatory infiltrate was found in most cases of all MTS. MTS was adequate removed in the most part cases.

On autopsy material of fifty corpses, age 0-75 (Institute for Pathology of Medicine Faculty in Belgrade and KBC
Dragiša Mišović - Dedinje, Beograd) we have met with all kind of comlications of bronchyectazia and bronchyloectazia
which were mentioned in literature. All statement complications, which caused death, we classified into lung and out lung
ones. Among lung complications, we stated that pneumonia among children in a big number of cases of congenital
bronchyectazia and cystic fibrosis of lungs. The apses of lungs were represented in four cases of secular and spindle shaped bronchyectazia and in one case of distal secular bronchyectazia it was represented in empiem pleure. In two cases lung gangrene was noted. Among out lung complications we can emphasize two cases of sepses of brain Apses. Leptomeningitis was present at one case. Among long-term spread bronchyectazia and bronhyloectasis with chronically manure inflammation and lung abscesses (bronchiectasiae abscendons), we stated the deposit of amiloids in glomerulus's and blood vessel of kidney intersticium as well as in liver and spleen. Chronical lung heart (cor pulmonale chronicum) was the most often complication of bronchyectazia and bronchyloectasia in the middle and older age period of our cases and it had represented the major cause of death.