NEZELJENA DEJSTVA NSAR NA SLUZNICI GASTRODUODENUMA ORDINIRANIH U TERAPIJI REUMATOIDNOG ARTRITISA

M. Popovic ,
M. Popovic
R. Dani ,
R. Dani
Lj. Stalevic
Lj. Stalevic

Published: 01.12.2014.

Volume 44, Issue 1 (2015)

pp. 55-59;

https://doi.org/10.5937/pramed1501055p

Abstract

Cilj rada je da utvrdi patoloske promene na sluznici gastroduodenuma (erozije,ulceracije, ulkusi, komplikacije ulkusa,subepitelna krvarenja i dr) nastale kao posledica stetnog dejstva NSAIL (Nesteroidnih antireumatika )lekova koji su ordinirani u terapiji Reumatoidnog artrit-(RA). Ispitivanje je vrseno na 100 bolesnika sa dijagnostikovanim RA koji su bili na kontinuiranoj terapiji NSAIL. Kod polovine bolesnika uradjena je gastroskopija da bi se verifikovale patoloske makromorfoloske promene pre kontrolisanog uzimanja NSAIL Posle 2godine uzimanja kontinuirane terapije NSAIL uradjena je kontrolna gastroskopija a patoloske makromorfoloske-endoskopske promene verifikovale. Posle dvogodisnje kontrolisane terapije NSAIL na sluznici gastroduodenuma erozije su opisane u 66% bolesnika, ulkus zeluca u 18%, duodenalni ulkus kod 14% bolesnika, krvarenja u 25% bolesnika.

Keywords

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