Oral health in patients with chronic kidney disease

Radojica Stolić Orcid logo ,
Radojica Stolić
Vekoslav Mitrović ,
Vekoslav Mitrović
Naja Suljković ,
Naja Suljković
Dušica Miljković-Jakšić ,
Dušica Miljković-Jakšić
Aleksandra Balović ,
Aleksandra Balović
Roksanda Krivčević ,
Roksanda Krivčević
Sanja Jovanović
Sanja Jovanović

Published: 01.12.2019.

Volume 49, Issue 1 (2020)

pp. 35-40;

https://doi.org/10.5937/pramed2002035s

Abstract

Objective: In the available literature data, there is not much information about problems of patients with end stage kidney disease in relation to oral health. Our objective was to show the importance of oral diseases for patients on hemodialysis. Data sources: In this review article, the sources of data are review articles and scientific articles in the English language published in MEDLINE database. The choice of studies was based on keywords: Chronic kidney disease, Hemodialysis, Oral health, Periodontal diseases. Results: It is assumed that almost 90% patients with chronic kidney disease manifest some symptoms of oral disease. Therefore, it is important to determine the impact of periodontal disease on the progression of kidney failure in these individuals, to evaluate inflammatory parameters in this patient population, to assess the degree of bone loss and periodontal disease index, to determine the presence of bacterial strains, paradontopathy of gingival fluid and antibody titers, to examine correlations of proinflammatory cytokines in the gingival sulcus and serum, as well as to determine the relationship between periodontal tissue and inflammatory mediators. Periodontal diseases can increase the possibility of developing chronic kidney disease by 1.5 to 2 times. These oral diseases include gingival hyperplasia, periodontitis, xerostomia, unpleasant breath, changes in the oral mucosa, malignancies, oral infections, dental abnormalities and bone lesions. Conclusion: This requires serious cooperation between nephrologists and dentists to make proper communication possible, in order to provide quality dental care for this growing patient population in accordance with new treatment strategies.

References

1.
KDOQI Clinical Practice Guideline for Diabetes and CKD: 2012 Update. Vol. 60, American Journal of Kidney Diseases. 2012. p. 850–86.
2.
Strippoli GF, Palmer SC, Ruospo M, Natale P, Saglimbene V, Craig JC, et al. Oral disease in adults treated with hemodialysis: prevalence, predictors, and association with mortality and adverse cardiovascular events: the rationale and design of the ORAL Diseases in hemodialysis (ORAL-D) study, a prospective, multinational, longitudinal, observational, cohort study. Vol. 14, BMC Nephrology. 2013.
3.
Grubbs V, Plantinga LC, Tuot DS, Powe NR. Chronic kidney disease and use of dental services in a united states public healthcare system: a retrospective cohort study. Vol. 13, BMC Nephrology. 2012.
4.
M.V. A, B.Y. H, P.L. F, S. K, J.A B. Fares G., et al: End stage renal disease as a modifier of the periodontal microbiome. Vol. 16. 2015.
5.
R. A, S. W, N. R, S. C, U. U, M R. Association of dental and periodontal disease with chronic kidney disease in patients of a single, tertiary care centre in Thailand. Vol. 6. 2016. p. 011836.
6.
Dioguardi M, Caloro GA, Troiano G, Giannatempo G, Laino L, Petruzzi M, et al. Oral manifestations in chronic uremia patients. Vol. 38, Renal Failure. 2016. p. 1–6.
7.
Simpson TC, Needleman I, Wild SH, Moles DR, Mills EJ. Treatment of periodontal disease for glycaemic control in people with diabetes. Cochrane Database of Systematic Reviews.
8.
Chambrone L, Chambrone D, Pustiglioni FE, Chambrone LA, Lima LA. The Influence of Tobacco Smoking on the Outcomes Achieved by Root-Coverage Procedures. Vol. 140, The Journal of the American Dental Association. 2009. p. 294–306.
9.
Kshirsagar AV, Offenbacher S, Moss KL, Barros SP, Beck JD. Antibodies to Periodontal Organisms Are Associated with Decreased Kidney Function. Vol. 25, Blood Purification. 2007. p. 125–32.
10.
Paraskevas S, Huizinga JD, Loos BG. A systematic review and meta‐analyses on C‐reactive protein in relation to periodontitis. Vol. 35, Journal of Clinical Periodontology. 2008. p. 277–90.
11.
Hernández C. Oral disorders in patients with chronic renal failure. Narrative review. Vol. 5, Journal Oral Of Research. 2016. p. 27–34.
12.
Soroye M, Ayanbadejo P. Oral conditions, periodontal status and periodontal treatment need of chronic kidney disease patients. Vol. 8, Journal of Oral Research and Review. 2016. p. 53.
13.
Anuradha B, Katta S, Kode V, Praveena C, Sathe N, Sandeep N, et al. Oral and salivary changes in patients with chronic kidney disease: A clinical and biochemical study. Vol. 19, Journal of Indian Society of Periodontology. 2015. p. 297.
14.
Kaushik A, Reddy S, Umesh L, Devi BKY, Santana N, Rakesh N. Oral and salivary changes among renal patients undergoing hemodialysis: A cross-sectional study. Vol. 23, Indian Journal of Nephrology. 2013. p. 125.
15.
Oyetola EO, Owotade FJ, Agbelusi GA, Fatusi OA, Sanusi AA. Oral findings in chronic kidney disease: implications for management in developing countries. Vol. 15, BMC Oral Health. 2015.
16.
F. S, S. H, A. T, H A. Eslami H.: Dental Health Status in Renal Dialysis Patients Compared to Healthy Individuals. Vol. 23. 2015. p. 844–52.
17.
Kim YJ, Moura LM de, Caldas CP, Perozini C, Ruivo GF, Pallos D. Evaluation of periodontal condition and risk in patients with chronic kidney disease on hemodialysis. Vol. 15, Einstein (São Paulo). 2017. p. 173–7.
18.
Verma S, Frambach GE, Seilstad KH, Nuovo G, Porcu P, Magro CM. Epstein–Barr virus‐associated B‐cell lymphoma in the setting of iatrogenic immune dysregulation presenting initially in the skin. Vol. 32, Journal of Cutaneous Pathology. 2005. p. 474–83.
19.
Alangaden GJ, Thyagarajan R, Gruber SA, Morawski K, Garnick J, El‐Amm JM, et al. Infectious complications after kidney transplantation: current epidemiology and associated risk factors. Vol. 20, Clinical Transplantation. 2006. p. 401–9.
20.
T. K, B. B, D. B, M V. Stolic R.: Impact of Chronic Kidney Disease Mineral and Bone Disorder on Jaw and Alveolar Bone Metabolism: A Narrative Review. Vol. 16. 2018. p. 79–5.
21.
Akar H, Akar GC, Carrero JJ, Stenvinkel P, Lindholm B. Systemic Consequences of Poor Oral Health in Chronic Kidney Disease Patients. Vol. 6, Clinical Journal of the American Society of Nephrology. 2011. p. 218–26.
22.
Stolic R. Most Important Chronic Complications of Arteriovenous Fistulas for Hemodialysis. Vol. 22, Medical Principles and Practice. 2013. p. 220–8.
23.
J.S E. New year challenges: major challenges facing today’s leaders of dental education. Vol. 12. 2004. p. 143.
24.
Spolidorio L, Spolidorio D, Massucato E, Neppelenbroek K, Campanha N, Sanches M. Oral health in renal transplant recipients administered cyclosporin A or tacrolimus. Vol. 12, Oral Diseases. 2006. p. 309–14.
25.
Radwan‐Oczko M, Boratyńska M, Ziętek M, Zołędziewska M, Jonkisz A. The Relationship of Transforming Growth Factor‐β1 Gene Polymorphism, Its Plasma Level, and Gingival Overgrowth in Renal Transplant Recipients Receiving Different Immunosuppressive Regimens. Vol. 77, Journal of Periodontology. 2006. p. 865–73.
26.
F. C, G. C, E. V, C. F, M.L. A, L. B, et al. Dental Care for Patients with End-Stage Renal Disease and Undergoing Hemodialysis. Vol. ID. 2018. p. 9610892 8.
27.
M. K, Y. M, Y. M, Y. O, K. M, T. M, et al. Pathological Characteristics of Periodontal Disease in Patients with Chronic Kidney Disease and Kidney Transplantation. Vol. 20. 2019. p. 3413.
28.
Souza CRD de, Libério SA, Guerra RNM, Monteiro S, Silveira ÉJD da, Pereira ALA. Avaliação da condição periodontal de pacientes renais em hemodiálise. Vol. 51, Revista da Associação Médica Brasileira. p. 285–9.
29.
H. Y, W. X, Z. CX, W. YD, J. LL, Z. XY, et al. Risk factors of periodontal disease in maintenance hemodialysis patients. Vol. 96. 2017.
30.
P.S D. Assessment of periodontal health of patients undergoing renal dialysis. Vol. 3. 2017. p. 397–9.
31.
Davidovich E, Schwarz Z, Davidovitch M, Eidelman E, Bimstein E. Oral findings and periodontal status in children, adolescents and young adults suffering from renal failure. Vol. 32, Journal of Clinical Periodontology. 2005. p. 1076–82.
32.
Olcay K, Eyuboglu T, Erkan E. Cyclic fatigue resistance of waveone gold, protaper next and 2shape nickel titanium rotary instruments using a reliable method for measuring temperature. Vol. 22, Nigerian Journal of Clinical Practice. 2019. p. 1335.
33.
A. T, A Y. The effect of periodontal therapy on glycemic control and fasting plasma glucose level in type 2 diabetic patients: systematic review and meta-analysis. Vol. 17. 2017. p. 31.
34.
Buhlin K. Risk factors for cardiovascular disease in patients with periodontitis. Vol. 24, European Heart Journal. 2003. p. 2099–107.
35.
Stolic R, Trajkovic G, Jovanovic A, Stolic D, Peric V, Sovtic S, et al. Carotid ultrasonographic parameters as markers of atherogenesis and mortality rate in patients on hemodialysis. Vol. 67, Vojnosanitetski pregled. 2010. p. 916–22.
36.
Slade GD, Ghezzi EM, Heiss G, Beck JD, Riche E, Offenbacher S. Relationship Between Periodontal Disease and C-Reactive Protein Among Adults in the Atherosclerosis Risk in Communities Study. Vol. 163, Archives of Internal Medicine. 2003. p. 1172.
37.
Stolic RV, Trajkovic GZ, Peric VM, Stolic DZ, Sovtic SR, Aleksandar JN, et al. Impact of Metabolic Syndrome and Malnutrition on Mortality in Chronic Hemodialysis Patients. Vol. 20, Journal of Renal Nutrition. 2010. p. 38–43.
38.
Stolic RV, Trajkovic GZ, Peric VM, Jovanovic AN, Markovic SR, Sovtic SR, et al. The influence of atherosclerosis and plasma D-dimer concentration in patients with a functioning arteriovenous fistula for maintenance hemodialysis. Vol. 40, International Urology and Nephrology. 2008. p. 503–8.
39.
Loos BG, Craandijk J, Hoek FJ, Dillen PMEW, Van Der Velden U. Elevation of Systemic Markers Related to Cardiovascular Diseases in the Peripheral Blood of Periodontitis Patients. Vol. 71, Journal of Periodontology. 2000. p. 1528–34.
40.
D’Aiuto F, Parkar M, Andreou G, Suvan J, Brett PM, Ready D, et al. Periodontitis and Systemic Inflammation: Control of the Local Infection                is Associated with a Reduction in Serum Inflammatory Markers. Vol. 83, Journal of Dental Research. 2004. p. 156–60.
41.
Bastos JA, Diniz CG, Bastos MG, Vilela EM, Silva VL, Chaoubah A, et al. Identification of periodontal pathogens and severity of periodontitis in patients with and without chronic kidney disease. Vol. 56, Archives of Oral Biology. 2011. p. 804–11.
42.
Castillo DM, Sánchez-Beltrán MC, Castellanos JE, Sanz I, Mayorga-Fayad I, Sanz M, et al. Detection of specific periodontal microorganisms from bacteraemia samples after periodontal therapy using molecular-based diagnostics. Vol. 38, Journal of Clinical Periodontology. 2011. p. 418–27.
43.
Vilela EM, Bastos JA, Fernandes N, Ferreira AP, Chaoubah A, Bastos MG. Treatment of chronic periodontitis decreases serum prohepcidin levels in patients with chronic kidney disease. Vol. 66, Clinics. 2011. p. 657–62.
44.
Ghabili K, Ardalan MR, Ghabili K, Shoja M. A causative link between periodontal disease and glomerulonephritis: a preliminary study. Therapeutics and Clinical Risk Management. p. 93.
45.
R.S. B, R.C. V, I.L. B, R.A. M, A.P R. Pepato M.T.: Lack of correlation between periodontitis and renal dysfunction in systemically healthy patients. Vol. 5. 2011. p. 8–18.
46.
Grubbs V, Plantinga LC, Crews DC, Bibbins-Domingo K, Saran R, Heung M, et al. Vulnerable Populations and the Association between Periodontal and Chronic Kidney Disease. Vol. 6, Clinical Journal of the American Society of Nephrology. 2011. p. 711–7.
47.
Iwasaki Y, Otsuka H, Yanagisawa N, Hisamitsu H, Manabe A, Nonaka N, et al. In situ proliferation and differentiation of macrophages in dental pulp. Vol. 346, Cell and Tissue Research. 2011. p. 99–109.
48.
Parkar S, Ajithkrishnan C. Periodontal status in patients undergoing hemodialysis. Vol. 22, Indian Journal of Nephrology. 2012. p. 246.

Citation

Copyright

Article metrics

Google scholar: See link

The statements, opinions and data contained in the journal are solely those of the individual authors and contributors and not of the publisher and the editor(s). We stay neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Most read articles

Indexed by