Acute louse born typhus is a nightmare to which our scientific medicine have provided significant importance.
Doctors in former Yugoslavia deem that the louse born typhus was rooted in Bosnia and Herzegovina from long time ago,
while in Serbia were individual cases without areas with pediculosis before the First World War, and there were no cases of
body pediculosis in villages. The author conducts medical, but also historical and linguistical research in order of collecting
data on louse borne typhus cases through information on causes of death written in death certificates. The research was done in more phases. The citizens were tested through questionnaires at the area of lower prevalence of louse borne typhus (only sero-positive cases); then at the area of higher prevalence (population through random sample). Contact with R. Prowazeki was established through sensitive serological method. In the final step, the popular name for typhus syndrome was checked - that is, if that name has been written into the death certificate. The objective of the research is to check if there were cases of louse borne typhus in the area of Metohia, and that was done through checking the death certificates. The author proves the endemics of the disease through explicit and implicit use of the name for the louse borne typhus during 1914 to 1935. This empirical check is the basis for the future researches of earlier endemic of louse borne typhus, this time through checking older documents from the used death certificates, which is kept in the archive of Serbia, town of Kotor, and other places. 

With this work we intended to examine antipyretical effect of different extracts from the leaf. The following extracts were examined: etherical chloroformic The experiments were conducted on white laboratory mice, type BALB/C. Mice were divided in 5 groups, where each group received the appropriate extract. Rectal temperature was measured by "Termistorowy" termometer. After the temperatures were measured, for each of examined group we defined area under the curve. The area values were later used to determine statistically significant differences between them. Examination results of antipyretic effects of different extracts ( ) from the leaf, i parsley (Et O), (CHCl ), ethyl-acetic (EtOAC), n-bhutanolic (nBuOH), aquae- 2 3 ous (H O). 2 etherical (Et O), chloroformic (CHCl ), ethyl-acetic (EtOAC), n-bhutanolic (nBuOH), aquaeous (H O) parsley 2 3 2 n experiment with mice, show that all the extracts mentioned above, decreased (annuled) pyrogenic effect of 12% yeast suspension. 

A 23-year-old primigravida in 7 weeks of pregnancy with tubal pregnancy. Clinical and ultrasound examinations indicated ectopic pregnancy; emergency laparatomy was performed. Intraoperatively, the tuabal pregnancy with a ruptured hole was revealed. Typical salpingectomy was carried out. Hystology confirmed tubal pregnancy. The postope-rative cours was normal.

Hypoxic-ischemic encephalopathy (HIE) and intracranial haemorrhage (ICH) are the most common neurological
diseases in newborn period. Very often they are caused by perinatal asphyxia and they may lead to permanent disturbances in psychomotor development of infants. The aim of this study was to evaluate the significance of neurological examination and other diagnostic methods in both diagnosis and prognosis of HIE and ICH in high - risk newborn infants. We prospectively examined the group of 115 infants who were followed till the age of three years in order to evaluate their neurological development. Neurological status during newborn period and the first year of life were abnormal in 62% of infants, ultrasound examination of the brain results were abnormal in 60% of infants and electroencephalographic records were abnormal in 23% of infants. Magnetic resonance imaging were done in 25 infants, showing patological changes
predominantly localized in periventricular white mater, basal ganglia and talamus in 10 of them. At the age of three years, we
found that seven infants had moderately severe neurological deficits and nine infants had severe neurological deficits. We
concluded that neurological examination and ultrasound examination of the brain were of limited diagnostic and prognostic
value while electroencephalographic examination was of great significance in infants with neurological disturbances.
Magnetic resonance imaging of the brain was very good method in evaluating pathological changes in the brain of studied
infants, and the spectrum of pathological changes correlated very well with the type of neurological deficits. Prognosis of
neurological development of infants with pathological changes predominantly localized in the region of periventricular
white mater were better than of infants with pathological changes in the region of basal ganglia and talamus who had very
bad prognosis.

The aim of our work was to inquire after frequency and characteristics of repeated myocardial infarction. We questioned prospectively 123 patients, diagnosed with acute myocardial infarction, who were hospitalized in the Coronary unit
of Krusevac Health centre, during the period of 01. 02.- 31. 07. 2001. Repeated myocardial infarction was found in 16,26%
of questioned patients. Non Q acute myocardial infarction was found in 35,00% on patients with repeated myocardial infarction and 8,74% on patients with the first myocardial infarction (p<0,01). In patients with repeated myocardial infarction
more often was found heart failure (55,00% vs 20,39%, p<0,01). Repeated myocardial infarction have difficulty clinical
flow, but have not statistical significantly higher early mortality

In this research it was examined how fatigue in the working process affected the speed of reaction on a complicated
stimulus, and also on the frequency of inadequate reactions. The investigation was carried out by means method of combine
reaction time (CRT). CRT is the shortest time that passes from the moment when a person is affected by a complicated stimulus until the moment when the person responds to the stimulus, by making adequate and complicated reaction. CRTwas registrated in working population of railroad employees who were divided in two groups:group of locomotive drivers (n= 44) and group of a railroad employees (n=25). In the group of locomotive drivers it was taken into the consideration whether the type of locomotive was electrical or diesel power. In both groups, CRT was registrated in two phases of working process; before and after daily work. Results showed that in both examined groups CRT got significantly extended after the
working process. Duration of CRT was longer before and after working process in the group of electrical power locomotive
drivers compared to diesel power locomotive drivers. Fatigue did not affect significantly on the frequency of incorrect answers

Menopause may influence negatively the cardiovascular system of women, especially that of smokers. The aim of
our study was to compare lipid levels and left ventricular function in postmenopausal women smokers and non-smokers
during 12 months of oral estrogen replacement therapy. The study group included healthy postmenopausal women, 30
smokers and 32 non-smokers. Before and in 6 month intervals the following parameters were followed: total cholesterol,
LDL-, HDL-cholesterol, triglycerides, blood pressure and echocardiographic parameters of systolic and diastolic left
ventricular function. Before therapy non-smokers had higher total and LDL-cholesterol, when compared to smokers. Oral
estrogen replacement therapy significantly decreased levels of total and LDL-cholesterol and increased HDL-cholesterol,
only in non-smokers. No change in lipid levels was observed in smokers. However, women who smoked longer had higher
triglyceride levels after 12 months of oral estrogen replacement therapy. Echocardiography revealed significant improvement of systolic and diastolic left ventricular function in non-smokers, while improvement of only systolic function in
smokers. Our study has shown that 12 months of oral estrogen replacement therapy may not have a protective role on the
cardiovascular system of postmenopausal women smokers

The research was conducted at the Department of Pathology and Histology of Clinical center of Novi Sad. We analysed the reports of autopsies of newborns (to 28 days old), stillborns and miscarried fetuses in 1991 and 2001. Found
malformations were classified according to organ systems. Results for 1991 show next structure of congenital malformations: 3 malformations of central nervous system (14.29%), 0 malformations of urogenital system (0%), 3 malformations of
gastrointestinal system (14.29%), 1 malformations of musculosceletal system (4.76%), 9 malformations of cardiovascular
system (42.86%), 1 chromosomal defects (4.76%), 4 multiple malformations (19.05%). Results for 2001 have next value: 9
malformations of central nervous system (27.27%), 4 malformations of urogenital system (12.12%), 5 malformations of
gastrointestinal system (15.15%), 0 malformations of musculosceletal system (0%), 4 malformations of cardiovascular
system (12.12%), 2 chromosomal defects (6.06%), 9 multiple malformations (27.27%). By the comperison of the results of
structure of congenital malformations in 1991 and 2001, we can conclude that the differences of cardiovascular and urogenital malformations are statistically important

Until sixties of twenty centuries, it was little now abaot cancer. It was well-know than chemicals , radiation, onko viruses, can to provoke cancer.Untill seventies it was clear than cancer is not infection or inborn sicness.Than eighties discovering onko-gens (gens normal indebted for growth of cell who is mute. Understad is than cancer cell could be continue growth, and they must have onko gen ON and cancer supresor OFF. Discover so and fenomena of apoptosissuicide cell what something wrong begin.For the time of nineties thay are discover reasons of apoptosis. The main one is TP53 gen on short part of hromosoma 17, with 1179 letter. It's understand than cancer begining with muting gens what is reason of growth, continuing with muting gens what suprim growing and finish with fold of last defence muting gen TP53.In therapy of cancer is searcing for agenc who will stimulate apoptosis.Big step what genetics do on understanding cancer give us reall chance to beat cancer.

Nosocomial infectious (NI) are very big problem nowdays. The aim of this was to investigate the level of knowledge of medicial students of University Pristina about NI and to compare the knowledge level of preclinical with knowledge level of clinical students about NI. Cross-sectional study was conducte in May 2001. The instrument of survey was questionnaire with 28 questions wich were distributed to all third-year (preclinical) students and to all fifth-year (clinical) students and to all fifth-year (clinical) students at the Medical Faculty Pristina. The majority of third-year students (78,2%) and fifth-year students (91,1%) knew the definition of NI and their reservoirs (100.0%). The fifth-year students gave correct answers, statisticaly significant, more frequently (X} =4.62; df=1, p<0.05). The majority of students (89,1% of third-year and 96,4% of fifth-year students) knew that NI could be prevented, but only 14,5% of third-year and 25% of fifth-year students considered handwashing the basic measure for prevention, although there is no statisticaly significant difference between third-year students (X' =2.62; df=1, p>0.05). Around 98% students percepted the risk of NI for medical staff. Around 80% of students estimated that the aditional lectures about NI are needed during the studies. The fifth-year students more frequently showed higher level of knowledge about multidrug-resistant bacteria (X* =17.77; df=1, p<0.01).

Approximately 70% of third-year students gained knowledge about NI from sources other than lectures, but 75% of fifth-year students gained that knowledge from lectures in epydemiology. Additional information about NI, especially about univesal precution, is needen for medical students. Tt is very important to appropriately organise the studies with more practical work in prevention of NI. The emphasise should be put on health edecation in order to increase knowledge about NI, general hygienic measures encouraging handwashing and correct use proper dezinfectans in order to control the hospital environment.