Defined daily dose (DDD) is arbitrary chosen technical unit for measuring medicament usage and it is not a recommended therapeutic dose. It is in fact a statistical parameter for monitoring medicaments usage, and it is related to the dose which is usually prescribed for the indication that the medicament was registered for. The aim of this work is to perform a detailed analysis of the extent and structure of the region of South Backa. Antiinfective medicaments in systematic use, according to the obtained data, participate with only 7.96 DDD/1000 inhabitants. The most applied pharmacotherapeutic subgroup with 2.99 DDD/1000 inhabitants is comprised of cephalexine and cephachlor. 

Chronic pulmonary heart (CPH) stands for presence of hypertrophy and/or dilatation of right heart ventricle caused by pulmonary hypertension as a consequence of diseases that are damaging lungs function or structure. By chronic pulmonary heart are not considered those hypertrophies of right ventricle which are consequences of left cardiopaths or congenital heart anomalies with skips. During the CPH evolution three stages were formed: a) uncomplicated pneumopathology, b) compensated chronic pulmonary heart and c) decompensated chronic pulmonary heart. The disorders of cardiac rhythm are often at decompensated CPH, which is proved by this scientific work as well. 40 sick people diseased of decompensated CPH are treated in purpose to establish the presence and the characteristics of cardiac arrhythmia at these patients. It is established that the major percentage of frequency is made by sinus tachycardia, atrial extrasystols, and ventricular extrasystols. Of 40 examinees 65% had sinus tachycardia, 37,5% atrial extrasystols, 30% ventricular extrasystols and 20% combined atrial and ventricular extrasystols. This proves us that there is a significant percentage of cardiac rhythm disorder frequency at the sick people of decompensated chronic pulmonary heart.

Premature labour is provoked by noumerous causes that represent a combination of socioeconomic, maternal and fetal factors, that usually act together. The introduction of of tocolytic agents in obstetric practice has not appeared to substantially change the incidence of preterm delivery. This problem is still one of the unsolved ones in perinatal medicine. The aim of the study was to present how structural and functional anomalies of placental physiology can be connected with this disarrangement of pregnancy.In our study of 327 pregnancies controled in our unit in 41 (13,26%) symtoms of premature labour were present: contractions, vaginal bleeding, abrevation and dilatation of cervical ostium. With adequate treatment, in form of combination of tocolytics, spasmolytics, hormones, nonsteroid antiinflammatorz drugs, antibiotics and atimycotics we have posponed delivery to term in 34 (82,92%) of cases. The use of appropriate medications, that blocks pahtophysiological mechanisms responsible for preterm labour in most cases we can enable prolongation of gestation and term delivery.

On autopsy material of fifty corpses, age 0-75 (Institute for Pathology of Medicine Faculty in Belgrade and KBC
Dragiša Mišović - Dedinje, Beograd) we have met with all kind of comlications of bronchyectazia and bronchyloectazia
which were mentioned in literature. All statement complications, which caused death, we classified into lung and out lung
ones. Among lung complications, we stated that pneumonia among children in a big number of cases of congenital
bronchyectazia and cystic fibrosis of lungs. The apses of lungs were represented in four cases of secular and spindle shaped bronchyectazia and in one case of distal secular bronchyectazia it was represented in empiem pleure. In two cases lung gangrene was noted. Among out lung complications we can emphasize two cases of sepses of brain Apses. Leptomeningitis was present at one case. Among long-term spread bronchyectazia and bronhyloectasis with chronically manure inflammation and lung abscesses (bronchiectasiae abscendons), we stated the deposit of amiloids in glomerulus's and blood vessel of kidney intersticium as well as in liver and spleen. Chronical lung heart (cor pulmonale chronicum) was the most often complication of bronchyectazia and bronchyloectasia in the middle and older age period of our cases and it had represented the major cause of death.

Foreign bodies of the lower respiratory ways represent a very important chapter in ENT and medicine in general,
becouse they can lead to child fatal results in very short time due the obstruction and suffocation. They considered as some of the most urgent states in medicine, so that the childs life depends on correctly and quickly made diagnostic and skilfully do
ne intervention. The authors have analysed the importance of anamnesis at the patients which have the foreign body in the
lower respiratory ways, hospitalized at the ENT Clinic and Pediatric Clinic of the CHC Priština, during the period of 1994 -
1999. Results of ork are showed that 132 childrens have been hospitalized during this period, and 119 of them were with
positively anamnesis for foreign body, while 13 were with negatively anamnesis, but with positive clinical and/or radiolo
gical findings. From 119 patients with positively anamnesis, 82.38% had positive TBSC finding, while patients with nega
tively anamnesis (13) had positive TBSC finding in 23.08% cases. The largest number of the children has been male pole
(64.36%), of the age of 3 and younger (73.27%), the most frequent foreign body was raw grain of bean (31.69%), and peanut (16.83%), and the most frequent localisation has been the right bronchi (57.43%). The most foreign bodies have been extracted by the upper tracheobronchoscopy (99.01%), while in only 0.99% of the cases tracheostomy and lower tracheobron choscopy applied. Positive anamnesis for foreign body of the lower respiratory ways was sufficient reason to indicate a tracheobronchoscopy, but if patients had positively clinical and/or radiological findings, negatively anamnesis must be interpreting very carefully

Urea is naturally present in healthy skin,but when the skin is dry, and in some skin condicions, such as eczema, psoriasis and dermatitis, the level of urea in the skin is reduced, because skin is dry and rough and irritation. Urea deserves a bigger role in our dermatotherapy and medical cosmetology-for curring skin disorders and for better care of healthy skin. Urea
helps replenish this essential skin component and help support the skin`s natural moisture levels.

The genes mutate either spontaneously or under the influence of mutagenic agents (irradiation, viruses, toxins).
The occurrence of genetic syndromes in the scope of one family is pointing more to the inherited than to de novo mutation.
Aim of this study was to present two syndromes in the same family tree, occurring subsequently one by one, which carry severe mental retardation and have a poor prognosis and frequently tragic outcome. A case report was given of a patient in
whom both pregnancies were completed by birth of the newborns presenting with severe syndromes: the first one with
Down's syndrome and the second one with Prader-Willi-Labhart syndrome. The results of investigation point to the necessity of genetic investigations before pregnancy and during pregnancy as early as possible, in order to avoid giving birth to
the children with syndromes which bear severe mental retardation and having poor prognosis.

Condylomata gigantea is an expansive, destructive lesion that affects most frequently anal and perianal region, and
rarely vulvar and vaginal region. We will describe a clinical case of a 28 years old female patient with a diagnosis of Condylomata gigantea in anal and perianal region with propagation on vulva, vagina and clitoris. After we detected a wide base of condylomas in anal and perianal region, we performed a deep, multiple biopsy for discover of eventual malignancy.
Histologically, malignancy was not confirmed, but it was discovered a presence of HPV types 6 and 11. The patient was initially treated with a wide surgical excision, and then the rest of condylomas were removed using CO laser which had an 2
haemostatic function in the same time. Three months later, there was no recurrence.

Trabeculodisgenesis of the primary congenital glaucoma because of the iris affiliate in front of the scleral ridge in
angulus iridocornealis. It is treated both surgically and with medication. We have showed you a patient which has, by the
time of illness diagnosing, developed morphological and functional optic papilla damages. We have applied both
comparative examinations and x-rays before and after sol. Xalatan therapy. With the research which is stillin progress, it is
estabilished that the values of intraocular pressure are brought to statistically normal frame (1,3 kPa-2,9kPa) and the
progression of both eyes´ optic nerves ganglion cells decadance is reduced, too

Acute louse born typhus is a nightmare to which our scientific medicine have provided significant importance.
Doctors in former Yugoslavia deem that the louse born typhus was rooted in Bosnia and Herzegovina from long time ago,
while in Serbia were individual cases without areas with pediculosis before the First World War, and there were no cases of
body pediculosis in villages. The author conducts medical, but also historical and linguistical research in order of collecting
data on louse borne typhus cases through information on causes of death written in death certificates. The research was done in more phases. The citizens were tested through questionnaires at the area of lower prevalence of louse borne typhus (only sero-positive cases); then at the area of higher prevalence (population through random sample). Contact with R. Prowazeki was established through sensitive serological method. In the final step, the popular name for typhus syndrome was checked - that is, if that name has been written into the death certificate. The objective of the research is to check if there were cases of louse borne typhus in the area of Metohia, and that was done through checking the death certificates. The author proves the endemics of the disease through explicit and implicit use of the name for the louse borne typhus during 1914 to 1935. This empirical check is the basis for the future researches of earlier endemic of louse borne typhus, this time through checking older documents from the used death certificates, which is kept in the archive of Serbia, town of Kotor, and other places.