Gonarthrosis is the most frequent artropathy of knee.The second joint of frequency and localisation osteorthrosis after joint of haunch. In complexive therapy of gonarthrosis, exept the medical therapy, important place has physical therapy
or special laser-therapy. 78 patients, where tested with a primary and secondary gonarthrosis, 19 men, and 59 women. They were all hospitalised on Rheumatology department of Internal Clinic of Clinical and Hospital Centre in Pri{tina. By objective using of parameters we show that, laser is a very important modern expedient on clinical results for gonarthrosis (volume of joint, volume of movements, muscle strength, and on the first pain, pain in static positions, pain in moving and night pain). It is seen that all values got by laserotherapy are statistically high significiant. During the use, of laserotherapy, the medical therapy was included.

Natural system of disease genesis is a complex occurrence. «Net» review of cause can be based on systematic approach and it doesn't have to, and so those are homonyms. Complex occurrence of the genesis of a disease is given as a arranged set by relation «predecessor-follower». Chain reaction is that one which has hierarchic arrangement because of managing. By systematic approach the causality is being created.

Change in left ventricular volumes, particularly end-systolic volume index is a major representative of left ventri cular dilatation, and is a predictor of mortality after acute myocardial infarction of anterior localization. Several large-scale trials have demonstrated beneficial effectiveness of ACE inhibitors on the process of left ventricular remodeling after myo cardial infarction, not only in patients with compromised systolic function. Aim of the study was to evaluate the influence of therapy for ACE inhibitors in the early faze of anterior myocardial infarction, trough dynamics of left ventricular volume in dexes. During six months 30 patients were evaluated with echocardiography in admission, before leaving the hospital, after
three and six months after myocardial infarction. In evaluated group there was increased end-diastolic and end-systolic vo lume index, but without statistically significant value. There were no new cardiac decompensations. We concluded that ACE inhibitors given in the early stage of acute myocardial infarction anterior localization have beneficial effect on the process of left ventricular remodeling and that is recommended to bee given to this patients, after excluded contraindications

Biliary calculosis is the most frequent disease of the hepathrombial system. Inflammation of the gall bladder appears in the acute and chronicle form. Acute inflammation presents one of the frequent complications of the gall bladder
calculosis. Acute inflammation of the gall bladder can appear in catarrhal, phlegmonous, gangrenous perforative form. Perforation of the inflamed changed gall bladder can lead to the diffuse biliary peritonitis, pericholecystitis and formation of
pericholecystitis infiltrate or abcess. Very often the acute inflammation of the gall bladder appears in combination with Acute inflammation of the pancreas. For the production of the work the biyearly material of the Emergency Surgical Centre
“Simonida” in Gračanica is used. In the ESC Simonida, in the period from January to December of 2004, 375 patients were operated. In the same period of time we operated 52 (13.86%) patients because of the gall bladder disease and biliary ways.
There were 45 female patients and 7 male ones. Gall bladder disease is 6.5 times more frequent at females in our material. Hard security situation and limited freedom of movement are one of the most important reasons of patients' late report to the
doctor, and appearance of the heavy forms of the inflammation of the gall bladder and biliary ways. The acute form of the inflammation of the gall bladder was noticed at 25 patients. The complications of the disease in the sense of cholecystopancreatitis, choledolithiasis, suppurating cholangiitis, choledolithiasis i cholecystoduodenal fistule were found at 27 patients. Postoperative complications were verified at 3 patients, wound infection at 2 patients and peritonitis at one
patient after drawing ouf the T-drain.

Defined daily dose (DDD) is arbitrary chosen technical unit for measuring medicament usage and it is not a recommended therapeutic dose. It is in fact a statistical parameter for monitoring medicaments usage, and it is related to the
dose which is usually prescribed for the indication that the medicament was registered for. The aim of this work is to perform a detailed analysis of the extent and structure of the region of South Backa. According to the obteined data, medicaments
used in treatment of gastroinestinal tract contributed with 15.52 DDD/1000 inhabitants per day. Most commonly used are antacids and anti-ulcer drugs (8.14 DDD/1000 inhabitants per day). Medicaments used in treatment of muscular and skeletal
system contributed with 14.30 DDD/1000 inhabitants per day. Antiinflammatory and antirheumatic drugs sre used in amounts of 14.18 DDD/1000 inhabitants per day. In our country there is no complex survey of drug usage because there is no way of monitor ing which could apprehend all possible information sources. Defined daily dose is not introduced into practical qualitative and quantitative monitoring. It is necessary to make systematic network of information sources to provide for insight into medicament usage

The retrospective study included all patients treated at Clinical Centre in Kragujevac, who needed an acute HD treatment due to vital endangerment, during 2003. The objective of this study was to demonstrate our experiences in treating these patients using central venous catheter. The results of this study show that femoral catheters are dominant (over 95%), with slight using of jugular and subclavial catheters (5%), in spite of the recommendation of the American Association for Renal Diseases to use femoral catheters only for patients supposed to be in hospital during the interval of 5 days. The
frequency of infections in our study (16,6%), coincides with the data of the American Association for Nosocomial Infections (NNIS)[1] (17,8% catheter infections). Gram-positive bacterium from Staphylococci group are the most frequent cause of catheter infections also in our patients

Besides big improvement of diagnostic, therapeutic and preventive procedures vascular disease generally and vascular disease of brain remain of biggest importance in total morbidity and mortality. This examination included patients in Urgent Surgery Center “Simonida” Gracanica. In article is represent relationship between brain and heart dysfunctions and it is obvious that cerebral disturbances can cause heart disturbances and also it can be in opposite direction. Well, based on this is very important to make fast and correct orientation: CARDIOCEREBRAL or CEREBROCARDIALSYNDROME. In diagnostic procedure and therapeutic treatment is necessary cooperation between cardiologist and neurologist because in most of these cases we have cardiocerebral or cerebrocardial syndrome. Better treatment patients with brain stroke claim teamwork different specialist.

Defined daily dose (DDD) is arbitrary chosen technical unit for measuring medicament usage and it is not a recommended therapeutic dose. It is in fact a statistical parameter for monitoring medicaments usage, and it is related to the dose which is usually prescribed for the indication that the medicament was registered for. The aim of this work is to perform a detailed analysis of the extent and structure of the region of South Backa. Antiinfective medicaments in systematic use, according to the obtained data, participate with only 7.96 DDD/1000 inhabitants. The most applied pharmacotherapeutic subgroup with 2.99 DDD/1000 inhabitants is comprised of cephalexine and cephachlor. 

Today it is noticeable that the incidence and mortality from cervical carcionoma increases, especially the growth of
frequency of those changes at younger women. The total number of diagnosis of invasive carcinoma at the processed biopsy and operative matrials was 186. The majority of results were the histological grade G1 N1 54,83% in the group of 41-50 years old patients, and the less significant was number of histological grade G2 N2 at the age 51-60 and G3 N3 at patients over 60 years old. In 72 cases the radical surgical treatment was done after previously made HP diagnosis of planocellular carcinoma on the biopsy material, and it was done in the cases that were operable in stage Ib (FIGO). The most of operated women were with histological grade G1 N1, so we followed in what degree the size of tumor, beside the histological grade G1 N1, so we followed in what degree the size of tumor, beside the histological grade, have an effect on the possibility of presence of the metastasis in regional lymphatic nodes. We came to the conclusion that with the growth of macroscopically size of tumor, the frequency of appearance of lymphatic nodes increases. Those parameters could not the small number of operated cases. When the disease is discovered in these histological grades. It is not operable, and then we perform radiotherapy as a method of treatment.

The genes mutate either spontaneously or under the influence of mutagenic agents (irradiation, viruses, toxins).
The occurrence of genetic syndromes in the scope of one family is pointing more to the inherited than to de novo mutation.
Aim of this study was to present two syndromes in the same family tree, occurring subsequently one by one, which carry severe mental retardation and have a poor prognosis and frequently tragic outcome. A case report was given of a patient in
whom both pregnancies were completed by birth of the newborns presenting with severe syndromes: the first one with
Down's syndrome and the second one with Prader-Willi-Labhart syndrome. The results of investigation point to the necessity of genetic investigations before pregnancy and during pregnancy as early as possible, in order to avoid giving birth to
the children with syndromes which bear severe mental retardation and having poor prognosis.