Most frequent congenital malformations in human are congenital heart disease (30%). In this article we represented basic of their etiology, pathogenesis, diagnostic and new therapeutics possibilities. Also we represented three cases of congenital heart disease. These cases we considered as very interesting. First of all, in this article we try to emphasize some aspects of this problem, which is not well known, especially in our environment. This very rare congenital heart disease shows how much diagnostic procedure can be difficult and treatment hard or impossible besides big improvement, which has be done last decades. We must learn much more about congenital heart disease!

Fibromyalgia presents a great clinical problem. Existence of no objective criteria for diagnosis is the key problem of this disease in the clinical rheumatology. The task of this work was to present the most practical quantification of fibromyalgia in every-day practice. Out of 37 patients there were 29 (78,3%) women, and 8 (21,6%) men. Out of this number there were 3 (8,1%) with primary fibromyalgia, 8 (21,6%) with secondary fibromyalgia, 25 (67,5%) were concomitant, whereas there was only one atypical case, i.e. (2,7%).

The Global Initiative for Chronic Obstructive Lung Disease (GOLD) has emerged due to joint efforts and support of the American National Heart, Lung & Blood Institute and the World health Organisation, with the objective of enlightening the major issues regarding COPD, and reducing the morbidity and mortality rates of this disease. An exacerbation of respiratory symptoms requiring hospital treatment is a common clinical manifestation of COPD. The exacerbation is usually induced by an infection of the tracheobronchial tree or air pollution, but in about one third of severe exacerbations the cause remains obscure. Acute COPD exacerbations are effectively treated by the application of inhalatory bronchodilators (particularly β-agonists and/or anticholinergics), teophylline and systemic, especially oral glucocorticoids. The patients with COPD exacerbation presented with the clinical symptoms of a respiratory infection (e.g. increased volume and altered colour of the sputum and/or fever) may benefit from antibiotic treatment. Non-invasive Positive Pressure Ventilation (NPPV) in acute exacerbations may improve blood gases and pH levels, reduce intrahospital mortality and the need for applying invasive mechanical ventilation and intubation, shortening thus the hospital treatment duration

The surface area of the small intestine is enhanced by three morphologic features that are peculiar to the gut: plicae circulares, the villi and the microvilli. The plicae circulares (circular folds) consist of mucosal/submucosal invaginations that are predominantly located in the duodenum and jejunum. These infoldings are visible on gross inspection. The intestinal villi, finger-like projections that protrude into the intestinal lumen, are approximately 0,5-1,5 mm long and cover the mucosal surface. They can be viewed by close inspection of the mucosa under low-power microscopy. Their microscopic appearance varies: duodenal villi are characteristically broad and leaf-shaped, jejunal villi are tall and thin, and ileal villi are short and broad. The length and shape of the villi also vary with geographic region. At the base of the villi, the epithelium enters the lamina propria and forms the crypts of Lieberkühn, which extend almost to the muscularis mucosae. The microvilli are sub-light microscopic tubular projections that are extensions of the apical cell membrane and compose the brush border. There are the enzymes and receptors in these structures which are required for terminal digestion and absorption

We want to present a boy with a several different, but benign disorders. Keratosis pilaris and strophulus infantum are very frequent, esspeciallv in children. Its association is not important. Pseudoacanthosis nigricans is especially associated with obesitas, and then this disorders is benign

Injuries of genital organs caused by electricity are rarely isolated and they begin with injuries of the other parts of a body. We present you a patient with very rare and difficult genital organs injury which brought to a very severe damage and lasting invalidity. The genitals were being carbonized but a patient have to spend the rest of his life with a final perineostomy.

Considering the fact that there are freer and more varying sex activities, we have today more varying genital organs injuries both at men and women. We present you a patient with two penis injuries caused by a bite. It must be done a complete wound treatment with ATprotection and maximum antibiotics appliance. It is necessary to perform an AIDS test.

The retrospective study included all patients treated at Clinical Centre in Kragujevac, who needed an acute HD treatment due to vital endangerment, during 2003. The objective of this study was to demonstrate our experiences in treating these patients using central venous catheter. The results of this study show that femoral catheters are dominant (over 95%), with slight using of jugular and subclavial catheters (5%), in spite of the recommendation of the American Association for Renal Diseases to use femoral catheters only for patients supposed to be in hospital during the interval of 5 days. The
frequency of infections in our study (16,6%), coincides with the data of the American Association for Nosocomial Infections (NNIS)[1] (17,8% catheter infections). Gram-positive bacterium from Staphylococci group are the most frequent cause of catheter infections also in our patients

Defined daily dose (DDD) is arbitrary chosen technical unit for measuring medicament usage and it is not a recommended therapeutic dose. It is in fact a statistical parameter for monitoring medicaments usage, and it is related to the
dose which is usually prescribed for the indication that the medicament was registered for. The aim of this work is to perform a detailed analysis of the extent and structure of the region of South Backa. According to the obteined data, medicaments
used in treatment of gastroinestinal tract contributed with 15.52 DDD/1000 inhabitants per day. Most commonly used are antacids and anti-ulcer drugs (8.14 DDD/1000 inhabitants per day). Medicaments used in treatment of muscular and skeletal
system contributed with 14.30 DDD/1000 inhabitants per day. Antiinflammatory and antirheumatic drugs sre used in amounts of 14.18 DDD/1000 inhabitants per day. In our country there is no complex survey of drug usage because there is no way of monitor ing which could apprehend all possible information sources. Defined daily dose is not introduced into practical qualitative and quantitative monitoring. It is necessary to make systematic network of information sources to provide for insight into medicament usage

The urgent surgical intervention need great atention in pregnant patients because of vital indication all surgical procedure interffer with pregnancy togheter with general anaesthesia and could cause complication of pregnancy and some times a damage of the foetus. Our study include all surgical procedure as the acute abdomen, trauma and politrauma in pregnant patient. Our aime was to give general anaesthesia which should be safe for mother and foetus.Post-operaative therapy and treatment of patients was done by theam of anaesthesia and gynecologists. The anaesthesia monitoring and surgical procedure have been improved up to the presset day but there are steel present great ricks in a treatment of this type of patients.The criteri in surgical and conservative treatment of pregnant patients was determined in colsultacion anaestetist-gynecologists.