Diabetes mellitus is the most frequently chronical disease.In the relation on the degree of affection populations (over 150 000 000 peoples), was able speak about pandemic of this illnesses. In the orgin of insulin-indipendent diabetes mellitus, the primary role has the insuline resistence. Date from literature gives the evidence that the metformin is a drug for insuline resitence. Behaind the rest, has been proved that metformin, decrease risk factors for beginning complications this illnesses

Cardiovascular diseases are one of the most significant social-medical problems. Having on mind their importance, the risk factors have been defined. Numerous clinical and epidemiological studies showed that deficit of magnesium in the human organism has a certain contribution in etiology, pathogenesis and evolution of cardiovascular diseases. RASKO, Rakovica's study of cardiovascular diseases, found out that these diseases are more frequent at the locations where
soft water with decreased content of magnesium is being used as drinking water. Magnesium is an integral part of about 300 enzyme systems in which catalyst's role have adenositriphospathase as Mg-ATP, a part of NaKATP-ase, exogenous and endogenous pumps for calcium, etc. A normal plasmatic concentration of magnesium is 0,8-1 mmol/l. Plasmatic level of magnesium is not directly correlated with actually content in an organism since 33% of plasmatic magnesium is connected with plasma's proteins and that's why hypoproteinemia can cause a false hypomagnesemia. The normal values of magnesemia don't exclude deficit of magnesium in an organism since PTH and calcitonin mobilize magnesium from the bones. Hypomegnesemia is caused by improper and irrational nutrition, hormone disturbances, and different conditions and diseases of an organism. Magnesium has vasodiletatoric, antianginosic, hypolipemic, antiagregatic effects. Mechanism of magnesium's effect is based on its physiological role in an organism, i.e. on correction of hypomagnesemia. In preventive and therapeutic purposes magnesium's compounds are used peroraly and parenteraly. With parenteral use the plasmatic concentrations of more than physiological 2,5-7,5 mEq/l can be attained in which case somnolentia can be appeared but not a coma nor depression of breathing. In prevention and therapy of cardiovascular diseases magnesium has a significant place in the largest number of cases as an adjuvant drug

Gout is a metabolic arthropathy caused by abnormal deposition of crystal histological they are urats (salts) of mononatrium in the joints and periatricular connective tissue. In 70% cases, decreased renal function in urats’excretion is responsible for hyperuricaemya. The other causes are mostly metabolic: increased (take in) of food wich contains mostly meat (purins) and increased synthesis of purin due to defective enzyme system (i.e. Lesch-Nyhan Sy)

With this case report we want to introduce is one rare disease, which can be spontaneonsly treat, buth it has a rare return. We present a pacient with rare febrile ulcero-necrotic variant, a possible persistent variant of PLEVA. The disease has been reprted in 20-th young adult

Most fistula-in-ano arise as result of chronic infection of an intersphincteric anal glands and persistence may be related more to non-specific epitelisation of the track. Preoperative definition of the anatomy of the fistulous track and the internal opening plays a primary role in adequate planing of the operative approach to minimize iatrogenic damage of sphincters and fistula recurrence. The diagnosis of anal fistula generally is straightforward and is based on clinical features. By
using palpation of the perianal area, digital examination, and careful probing of the track, the fistula anatomy was defined.
Fistulography, radiografic evaluation, is not routinely indicated in the initial avaluation of fistulas but may be helpful in identyng an occult cause of recurrent or multiple fistulas or if examination is suggestive of inflammatory bowel disease. AIM:
is evaluation of importance of the fistulography for surgical treatment of the fistula-in-ano. The study is prospective. In includes 60 patients divided in two groupies, each 30 patients. Examined group was operated after clinical findings by using
careful probing of the track and fistulography. Control group was operated after clinical findings by using careful probing of the track. In patients, examined group, treated with fistulography allowed a corect diagnosis of primary track 43.3%, secondary track 40.0%, horseshoe track 50.0% and internal opening in 40.0% of patients. The clinical findings, in the same group patients, allowed diagnosis of primary track 76.6%, secondary track 60.0%, horseshoe track 100% and internal opening in 73.3% of patients. Preoperative definition of fistulous track and internal opening by physical examination and its relationship with anal sphincters are important factors influencing the results of surgical management. We do not recommend routine fistulography in the diagnosis of fistula-in-ano. 

In process of chlorine-alkali electrolyze the big mercury failure exist in vapor shape, which across respiratory system, expire in exposed persons organism. The aim of the work was to examine connection between mercury vapor air pollution and sicknesses coming from diseases belonging to the XI group of diseases by International Classification of Diseases th (ICD) - 10 revision. Exploring groups were workers “Kalium chemistry” factory and administration at CI ”Zupa”. Recognized diagnosis on periodical exams year 2000, 2002 and 2004 were entered in reports (expertises) analyzed later on. Analyzed reports for total 571 examinees were done, 184 examinees year 2000, 191 examinees year 2002 and 196 year 2004. As of diagnosis recognized the diagnoses were separate for diseases belonging to XI ICD group. Examinees were divided in a four group according to the grade of exposure: I group day by day exposed; II group sporadically exposed; III group earlier
exposed; IV group not exposed. First, second and third group of examinees were workers of “Kalium chemistry” factory. It was established during the examination at rooms were exposed workers stay that only mercury vapor pollution 3.01 overcomes Maximum Permitted Concentration allowed by JUS. The frequency differences testing between groups according to the grade of exposure, like as frequency differences testing of sicknesses between all exposed opposite un-exposed, showed
to us that differences are statistically significant. Based on the results of the this research it can be conclude that connection exist between mercury vapor air pollution and sicknesses coming from diseases belonging to the XI group of diseases by ICD.

Very important role in the forensic investigation of mass graves takes forensic anthropology. Anthropologists take
part during the exhumation and later through the investigation and identification procedures. Forensic investigations of
mass graves in Kosovo and Metohija are going on. In this paper we observe all cases that were exhumed and identified during 2001., 2002., 2003. till the 1. 05 2004. In this time 280 dead bodies were exhumed and forensic team did autopsies, but
111 dead bodies were identified. Our aim was to analyze anthropological measurments (gender, age and stature) and compare them with the real state on identified dead bodies. Scientifics all over the world made the record of the very good results
of anthropology work. After our investigation we can say that anthropology is very valuable during the exhumation of mass
graves.

The aim of our work was to inquire characteristics of myocardial infarction in diabetic patients.We questioned
prospectively 441 patients, diagnosed with acute myocardial infarction. Diabetes mellitus (DM) was found in 31,3%
patients. Atrial fibrillation was found in 16,7% patients with DM and 7,3% on patients without DM(p<0,05).Ventricular
arrhythmias gr.III was found in 18,8% patients with DM and 15,8% on patients without DM (p>0,05), gr. IV 24,6% vs.
12,9% (p<0,05) and gr.V 18,1% vs.9,9% (p<0,05). Heart failure (NYHA I) was found in 10,9% patients with DM and
10,6% on patients without DM (p>0,05), heart failure NYHA II 13,8 vs.10,6% (p>0,05), heart failure NYHA III 14,5% vs.
5,6% (p<0,05) and heart failure NYHAIV 10,1 vs. 3,3% (p<0,05).Cardiogenic shock was found in 21,7% patients with DM
and 10,2% on patients without DM (p<0,05). QRS scor was found 8,3+-2,9 in patients with DM and 4,5+-1,5 on patients
without DM (p<0,05). In-hospital mortality was found 20,3% in patients with DM and 8,2% on patients without DM
(p<0,05). Post-hospital mortality was found 10,2% in patients wuth DM and 5,1% on patients without DM (p>0,05).
Myocardial infarction in patients with DM have difficulty clinical flow and higher mortality

Penetrating injuries of the eye are an important cause of unilateral visual loss. Hemophthalmos is frequently and
serious complication in penetrating eye injuries. We studied a series of 422 cause, children aged 1-15 years, treated from
1989 through 1998. There were 324 (76.78%) boys and 98 (23.22%) girls in the study group, with a mean age of 8 years 4
monats. Complication from penetrating eye injuries with hemophthalmos is noticed in 62 cases (14.69%). 

Luteal phase defect is disorder of low progesterone secretion (low level), or very short luteal phase (shorter than 11 days). Consequence of that is late endometrium maturation, almost 2 days. Such endometrum impedes and makes impossible ovum nidation. Today we have luteal phase defect in 14% of infertility women, and in 21% of women of unknown infertility reason. This has been frequently seen in women with spontaneous abortion and hyperprolaktinemia. Diagnostic methods of DLF are biopsy of endometrium and measuring of progesterone level. The aim of this study is the examine endometrium maturation disorders. The study includes 30 women that are hospitalized in Clinical of Gynecology Pristina. Unknown reason of infertility and normal hormonal status had been in 13 (43%), and hyperprolaktinemia in 7 (56,7%) of women. Histological verificated ovulation had been finding out in 60%of women. Late endometrium maturation, luteal phase defect, had been verificated in 23,3% of women, from there in 29,4% of hyperprolaktinemic women and in 5,4% of women of unknown infertility reason. There was evidence of late endometrium maturation of 2 days (85,7%). and of 4 days th (5,4%). Progesterone level in DFLthe 20th day was 30 nmol/l, the 24 day of menstrual cycle was 28,8 nmol/l. Progesterone level in women with histological proved regular endometrium maturation was higher and it was 45, nmol/l. The lowest progesterone level that can be find in good functioning of luteal body was 31,8 nmol/l.Citohormonal findings in DFL was showing progesterone domination. Take a look at infertility and ovarian function must not be concern only on ovulation, it must take care of endometrium maturation.