Sjögren'ssyndrom is autoimmune disorder where cells of immune system afack and destroy eccrine glands which produce tears and spit. We have a patients with following problems: dryness of the bucal lining and conjunctiva, dysphagia of solid food, paint in joints amd muscles, hand sensitivity to coldness.

Eosinophilic Granuloma (EG) represent the most benign and localized form of the three Langerhans cell histiocytosis syndromes. In bone, it is a tumor-like proliferation Langerhans cells. Intraosseous EG lesions can be solitary or multifocal. EG accounts for 60-70 % of Langerhans cells histiocytosis cases. The authors are describle a 21 year-old men with Eosinophilic granuloma. The disease had a rarely course with disorders multiple lesions in bones

Traumatic extraction of permanent teeth (avulsion completa) is a serious teeth injury with uncertain outcome and it requires dentist's on duty fast and adequate reaction. In this study a complete therapy plan for eleven year old girl, who came to the Clinic because of avulsed teeth 11, third class fracture of tooth 12 and second class fracture of tooth 21, was showed. After clinical examination and upper frontal region X-ray, we started with replantation of the tooth 11, as well as with wirecomposite splint placement. After successfully done replantation and injured teeth endodontic treatment, prosthetic sanation of the patient was done. In this study, clinical picture of the patient one year after the injury was also showed.

The biggest Serbian medival hospital had founded Stefan Urosh III Nemanjich in the monastery named Dechani. In 1340, it had been founded the hospital of the emperors Dushan in monastery of St.Arhangel near tawn Prizren. By liberation of the province Kosovo and Metohija from the Turkish rule and by united with Serbia,the health had been diveloping in this region. In 1922, it had been founded the state hospital in 1931. Governor, and in 1938, this hospital had the 120 beds and three laboratory rooms for analyses of blood and of urine. In 1924, it had been formed the first bacterologist station in Prizren. In 1928, it had been formed the State childrens home which is in 1929. had been become public health station with the general school ambulanta first aid station,bathroom and laboratory. In 1927. it had been working the Polyclinic in Prishtina were theyhad been carrying on the laboratory analyses.In these health resorts in the province of Kosovo and Metohija have been carrying on the analyses of blood, urine and of bowel as and the microscopy of preparation to malaria and it has been carrying on the education of skilled workers for these analyses. After the Second World war it had been carrying on the education of laboratory technians it the courses and by opening of laboratories in hospitals and health stations in Kosovo and Metohija the specialization of medicine biochemistry have been ending a lot of pharmacists who give a famous contribution to the development of biochemistry in this territory.

Periodontal disease is a chronic inflammatory disease that is largely attributable to infections with gram-negative bacteria and is characterised by both gingival inflammation and alveolar bone resorption. Beside macrophages, the second most common cells of the gingival inflammatory infiltrat are mast cells. Mast cells are heterogenous cell population which live from six months to one year. These cells are activated by differnt immunologic and non-immunologic signals. Activated mast cells can secrete a range of substances that regulate angiogenesis, tissue remodeling and wound healing, which include both degradation and synthesis of tissue components. Apart from that, mast cells have an important role in phagocytosis, antigen processing and presentation to T-cells. It is confirmed that gingival mast cells can express matrix metalloproteinases (MMPs) and the tissue inhibitors of metalloproteinases, TIMP-1 and TIMP-2. This indicates that mast cells are likely to play an important role in inflammation and tissue degradation in periodontal diseases.

Despite progress in conventional pharmacology in producing effective drugs, the plant kingdom might provide a useful source of new anti-ulcer compounds for development pharmaceutical entities or, alternatively, as simple dietary adjuncts to existing therapies. Botanical compounds with anti-ulcer activity include flavonoids(i.e.quercetin, naringin, silymarin, anthocyanosides, sophoradin derivatives) saponins (i.e. from Panax japonicus and Kochia scoparia), tannins (i.e. from Linderae umbellatae), gums and mucilages (i.e. gum guar and myrrh). This article reviews the gastro-protective and anti-ulcer properties of the most commonly employed herbal medicines and their identified active constituents. Among herbal drugs, liquorice, aloe gel and capsicum (chilli) have been used extensively and their clinical efficacy documented, but тhe documented literature has centred primarily on pharmacological action in experimental animals.

There are many forms of physical energy which, during such a short period of time, had rich history and which found wide application in the science of medicine, as was the case with the ultrasound in the last fifty years or so. The ultrasound got its affirmation rather soon, as valuable biologically harmless method used for detecting and explaining various pathological conditions in the science of medicine, and therefore in otorhinolaryngology as well. In the following study, the technique of the ultrasound examination of paranasal sinuses is described in details, standard echogramic patterns are
represented, and means of their interpretation are explained as well, regarding the fact that it is not standard. Special focus is
on the literature review whereby the valorization of the ultrasonography in relation to acute and chronic diseases of the maxillary sinuses is performed. In that sense, over 30 extracts by the authors from all parts of the world are represented. The
insight into the results of the latter reports, as well as the author own experiences, lead to the conclusion that the A-mode
ultrasonography represents an impartial method applicable in diagnostics of the maxillary sinus diseases. It is practical and
economical for it is performed quickly and in a rather simple manner. It is an invasive and painless method, comfortable for
the patient. Main advantage in relation to other radiological methods lies in the avoidance of the patient and medical doctor's
exposure to X-rays, therefore the ultrasonography method is a matter of choice for diagnosis of primarily maxillary sinus
acute diseases with children and pregnant women. Due to extraordinary sensitivity in the evaluation of the sinus secret, with
acute diseases it represents valuable, impartial supplementary method. On the other hand, due to weaker peculiarity, with
chronic diseases ultrasonography only represents a selective method

Work construe problems in children's protenuria.It is about physiology, pathological and insulated protenuria, also observation of examination stages of children with protenuria. It is about glomerul filtration and ultrafiltration barrier. Histochemical aspect show us that membrane is between palmately extensions and electromicroscopically aspect which indicate on subendotel part of basic membrane. About tubular absorption and removing of albumin from primary ultrafiltrate. Work is about proximal tubul and mechanism for reabsorption and transport of protein and peptid. Pathological protenuria is segmented on glomerul,tubul,hiper-production/overflow,and histuria. Work contains protenuria in different forms, transitiv, ortostatic and persistence. There are prepositions of three phases in examinations of protenuria

Allergen-specific immunotherapy (SIT) is the practice of administering gradually increasing quantities of an allergen extractto an allergic subject to ameliorate the symptoms associated with the subsequent exposure to the causative allergen. The major objectives of SIT in alergy disorders are, in the short term, to reduce the allergic triggers precipitating symptoms, and, in the long term, to decrease allergy inflammation and nonspecific bronchial hyperreactivity when bronchial remodeling is not prominent. The mechanisms of SIT are complex but it was convincingly shown to act by modifying Th2 cell responses either by immune deviation (increase in Th0/Th1) or T cell anergy (decrease inTh2/Th0) or more likely both. Specific immunotherapy is the only treatment that may alterthe natural course of allergic disease.

In this work we present a basic aspects of ionising radiation (afterward of depleted uranium), this effects to human organism, esspecially on radiobiological, health effects on human skin. Health effects ionising radiation on skin depends of its doses. High doses given stron reaction, already in a few days after radiation, and later manifestations arise after longer exposition lower doses this radiation. In this work we present a basics pathophysiological aspects, without specifical clinical manifestations of radiation dermatitis.