Getting on in years individually becomes the biggest risk factor in appearance of the woman's brest cancer. From the entire number of new discovered woman's breast cancers, 48% are women older then age of 65. Woman's breast cancer discovered by persons got on in years diagnose in getting forward condition of illness besides bigger cancer freqvency with propitious histology and biological profile. There are not enough proper studies about the breast cancer in elderly. For the project development material has been used from the surgical clinic and clinic for Oncology, as wellas institute for Pathology of the clinical centre in the city of Nis.The data from our serial direct attention to rarer conduct of standard diagnostic procedures at elderly with breast cancer. Also the conectivity between years of the patients; and time being passing from the initial diagnosis until treatment has been studied. Using pathhistology exam we were reseiving information about histological type of cancer, about the size of cancer, histological and nuclear grade, as well as absence or hold of metastasis process of lymph nodus. The most frequent used surgical procedure was radical mastectomy modified by Madden and Patey. The presence of complications has been tracked in the postoperative progress. In the postoperative progress depending on condition of breast cancer histological and nuclear grade, hold of the lymph knots,positivism of hormonereceptors, presence of comorbidity female patientswere subjected to adjuvant therapy. With purpose of perception of diagnoses as well as caracteristics and results of treatment of the female patient's survival has been tracked. The average survival in the examined group was 21 months while it was 31 month in the control group

The role of Eustachian tube dysfunction in chronic middle ear inflammation etiopathogenesis is obvious and almost always present. Shorter length of m. tensor velli palatini, the only active opener of the Eustachian tube, is related to tube dysfunction. The aim of the study is to investigate correlation between soft palate length, angle formed between soft and hard palate and chronic middle ear inflammation occurrence. Examinations have been performed on 60 adults. Group A consisted of patients suffering from chronic middle ear inflammation, whereas group B consisted of healthy individuals with respect to their gender and age. Examinations included medical check-up, auditory findings, radiological examinations and craniometrical X- ray measurements performed using lateral head X-ray. Soft palate length and angle formed between soft and hard palate angle were measured. It has been determined that soft palate length (distance from spine nasalis to the top of the uvula) is shorter in patients suffering from chronic middle ear inflammation ( average value for group A= 3,09, SD=0,422, whereas for group B =3,747, SD=0,448). Student test results indicate highly significant difference between examined groups ( value of variable t=6,025). Angle formed between hard and soft palate is higher in group A examinees (average value 138.4, SD=9.379, than in control group (average value 132,17, SD=8.765). Value of the variable t=2,658 indicate the significant differences in values between examined groups. Soft palate in patients suffering from chronic middle ear inflammation is positioned more horizontally and its length is shorter than in control group B. Depth and volume of the nasopharynx is lesser in group A patients. These soft palate dimensions impact soft palate muscular disbalance, mostly m. tensor velli palatini. In dysfunctional tube, medial lamina cartilage rotation is insufficient and muscular movement is minimal. Defining soft palate dimensions and nasopharyngeal morphology Eustachian tube dysfunction can be explained and chronic middle ear inflammation development predicted

Breast cancer remains one of the most common malignancies in women and is one of the leading causes of cancerrelated mortality. Despite the current emphasis on breast conservation, mastectomy rates remain at 30%. Mastectomy is often associated with significant psychological sequelae including distorted body image and sexual dysfunction. Breast restoration is assumed to allow a full emotional and physical recovery from a breast cancer crisis. Autogenous tissue gives the best results, and currently the best technique in most women is probably the free DIEPflap. there is theoretically minimal functional loss, minimal risk of hernia, less postoperative pain, and shorter hospitalization. However, there is a range of options, such as other flaps and use of implants, which can be tailored to specific situations

Visual acuity in the patients who suffered from end stage renal disease (ESRD) on hemodialysis (HD) treatment is essential prerequisite of good life quality. PURPOSE: to evaluate the prevalence and causes of visual impairment at the patients on HD. METHOD: 71 patients on HD were assessed with this study. The main outcomes were best corrected visual acuity and primary cause of visual impairment. RESULTS: statistical significance obtained for the followed refraction errors: 42 % of patients had hyperopia (p<0.000; 95% CI 0.36-0.48) and 15% of them myopia (p=0.030; 95% CI 0.11-0.19) as well as low vision (amblyopia) at 6% (p=0.024; 95%CI 0.03-0.09). CONCLUSION: it's necessarily to provide regular monitoring of all patients on HD. Prevalence of refractive errors and visual impairment is more often among patients on HD then on general population

Systematic and programmed physical exercise, called training, play a significant role in human health and ability improvement. A moderate physical exercise is considered as a very efficient method of increasing general physical ability and reaching the top results in sport, and simultaneously contributes to health quality of persons having sedentary professions. In active sportspersons, ability of cardiovascular, respiratory and bone-muscle systems are determined by training quality itself. Sportspersons show characteristically better adaptability of neurohumoral system to effort, as well as a higher activity of intracellular enzyme systems. Well-dosed physical exercise has an exceptional influence on human health, above all by regulating cholesterol blood level and electrolyte level of serum, whose minimal change can directly affect human health. This study was aimed to establish quantity and quality of organism response to physical exercise, in regard to level of daily training, by determining lipid fractions level in serum and electrolyte composition of serum. The study involved 50 healthy men in age between 20 and 25, divided into two groups. The first group was composed by physically untrained men, chosen by the random sample method. The other group of subjects was composed by 35 active sportsmen, chosen by direct selection for the best-trained ones among them. In order to reach a submaximal exertion, we used Astrand's test of submaximal exertion on the bicycle-ergometer. Blood samples were taken immediately before and after testing. The following parameters were determined in blood serum: high-density lipoproteins (HDL), low-density lipoproteins (LDL), triglyceride + + 2+ 2+ - content, as well as concentration of sodium (Na ), potassium (K ), calcium (Ca ), magnesium (Mg ) and chlorine (Cl) ions. On the base of our research we concluded that physical exercise of submaximal intensity did not lead to any quantitative and qualitative change of lipid fractions in blood serum of untrained persons. Physically inactive persons had higher serum concentrations of triglycerides and total cholesterol in regard to the investigated sportsmen. At the same time, sportsmen showed a higher HDL content of serum. Physical exertion in sportsmen led to a significant rise of triglycerides and highdensity lipoproteins content of serum, and the levels of total cholesterol and low-density lipoproteins did not changed + ++ significantly. Physical exertion of submaximal intensity in both studied groups caused a significant increase of Na , Ca and ++ + - Mg ion concentration, while concentration of K and Cl ions did not changed significantly. Numerous clinical studies showed that moderate aerobe exercise amplifies endothelial function and reduces cardiovascular risk

Old age can be defined as a variety of changes in structure and function which begin at the stage of reproductive maturity, and that changes are manifested as a lesser ability of adaptation and lesser way of defending from the influence of outside and inside factors. Neurons of sympathetic trunk, as well as the other neuron cells, are changeable during the life. Neurobiological, old age begins at the time of birth, because the number of neurons is not increasing, it's only getting lower, which means that neurons are post mitotic cells. The process of old age is increased with some degenerative changes at some diseases and its hard to know what belongs to, so called, physiologic way of getting old and what is pathologic. Concentration of lipofuscin in cells (pigment of old age), is the parameter for physiologic old age of a person. Concentration is changeable, and it depends from the tissue or the organ, concentration is controlled by the internal regulatory factors and the factors of environment as the way of nutrition, physical activity, stress and hygienic factors.

The aim of work was to find out whether multiparity led to increased morbidity and mortality of mothers multyparous. Special attention was paid to appearance of diseases among mothers, both those developed during pregnancy and immediately after delivery. Multiparity is especially characteristic of women of Albanian nationality. Thus it is obvious that there is a reverse proportion between multiparous women and level of education the higher level of education is the smaller is the number of previous deliveries. There is a significant difference in apsolute number of deliveries according to the place of living in favor of rural residence. Number of both EPH gestoses (Eclampsia, pre-eclampsia) and indications for Caesarian section is increasing with multiparity. Abruption of normaly inserted placenta is significantly more frequent among multiparous women. It is obvious that multiparous women more frequently have bleedings during third and forth delivery period. There were also a large number of hysterectomies during delivery (75). Death rate of women is significantly increasing with multiparity. Eclampsia is the cause of death among more than half of all women. Resuming all data the autor is pointing out that grand multiparity, giving birth to more than six children, is, mfom medical point of view, an increased risk both for a newborn and a pregnant woman. Perinatal motality and morbidity is increased and high risk during pregnancy, delivery and puerperium is simultaneously rising until the pregnant woman's life is seriously endangered

Work construe problems in children's protenuria.It is about physiology, pathological and insulated protenuria, also observation of examination stages of children with protenuria. It is about glomerul filtration and ultrafiltration barrier. Histochemical aspect show us that membrane is between palmately extensions and electromicroscopically aspect which indicate on subendotel part of basic membrane. About tubular absorption and removing of albumin from primary ultrafiltrate. Work is about proximal tubul and mechanism for reabsorption and transport of protein and peptid. Pathological protenuria is segmented on glomerul,tubul,hiper-production/overflow,and histuria. Work contains protenuria in different forms, transitiv, ortostatic and persistence. There are prepositions of three phases in examinations of protenuria

Periodontal disease is a chronic inflammatory disease that is largely attributable to infections with gram-negative bacteria and is characterised by both gingival inflammation and alveolar bone resorption. Beside macrophages, the second most common cells of the gingival inflammatory infiltrat are mast cells. Mast cells are heterogenous cell population which live from six months to one year. These cells are activated by differnt immunologic and non-immunologic signals. Activated mast cells can secrete a range of substances that regulate angiogenesis, tissue remodeling and wound healing, which include both degradation and synthesis of tissue components. Apart from that, mast cells have an important role in phagocytosis, antigen processing and presentation to T-cells. It is confirmed that gingival mast cells can express matrix metalloproteinases (MMPs) and the tissue inhibitors of metalloproteinases, TIMP-1 and TIMP-2. This indicates that mast cells are likely to play an important role in inflammation and tissue degradation in periodontal diseases.

Allergen-specific immunotherapy (SIT) is the practice of administering gradually increasing quantities of an allergen extractto an allergic subject to ameliorate the symptoms associated with the subsequent exposure to the causative allergen. The major objectives of SIT in alergy disorders are, in the short term, to reduce the allergic triggers precipitating symptoms, and, in the long term, to decrease allergy inflammation and nonspecific bronchial hyperreactivity when bronchial remodeling is not prominent. The mechanisms of SIT are complex but it was convincingly shown to act by modifying Th2 cell responses either by immune deviation (increase in Th0/Th1) or T cell anergy (decrease inTh2/Th0) or more likely both. Specific immunotherapy is the only treatment that may alterthe natural course of allergic disease.