Anxiety disorders are very common illnesses that are reported in approximately one third to one quarter of the entire population during the lifetime. Many anxiety disorders are being reported early in life, they have chronic progress, and cause significant difficulties, interfere in daily life activities and create huge economical expenses. It has been evaluated that 46.6 billion dollars out of 147.8 billion dollars overall mental disorders expenses in US is being spent on anxiety disorders, while in European community those expenses exceed 41 billion Euros. In spite of that, pharmacoeconomical aspects of these illnesses so far drawn much less attention than so called large mental illnesses (schizophrenia, depression), and the reason for that is probably that earlier relatively cheep benzodiazepines were dominantly used in treating anxiety disorders. However, in newer times the anti-depressives became the first choice for anxiety disorders, especially those from the group of selective serotonin reuptake inhibitors (SSRI). The increase of anxiety disorders prevalence and changes in modern pharmacotherapy create promising research conditions for starting the studies in area of pharmacoeconomics in the world, and in our country

The tibial and femoral shaft fractures representing prototyp in orthopedic traumatology and great problem for resolving. The speed of limb recovering functionality after surgery is important, and often desicisive for result of treatment. Place of external fixation (EF) in surgical treatment of femurs in DCOS (damage control orthopedic surgery), cominutions of femoral shaft and open fractures, rarely as definitive method. EF in treatment of tibial shaft fractures today take a place as a definitive method like intramedulary nailing. On department of orthopedic surgery in HC Kosovska Mitrovica we examined quality of life and speed of lower limb recovering functionality on 70 patients treated with EF tip Mitkovic as a definitive curative method. The time of achieving early function of lower limbs we divided on 4 levels, and writed time when patients achieved level 3 and 4. Also this timing we compared with middle time of healing tibial or femoral shaft fractures (golden standard) .We examined quality of life with EuroQol 5D evaluation system. 90% of our patient in period 8 to 12 weeks achieved level 3 and 4. There statisticaly significant diference between examined gropu and golden standard, p<0,05. We concluded that EF tip Mitkovic as definiyive curative method improved the speed of lower limbs recovering functionality. Quality of life is very high, 84 points. The number of complications where expected and in proportion with literatures data.

Prepathogenesis of mass occurrence of disease as a complex happening is hiding the “screen”. Social influence remained hidden inside school «25. may», which had as a consequence shown higher distribution of manifested disease. As the main point at performance of events is scientism based on “black box system”. There is uncritical trust in paradigm, statistic methodology there comes “parroting”. Sheltered by screen content of the events, between the enter of the first (sub)system and exit of the final (sub)system the most critical maintain “mixed approach”, with the aim to reveal into the real dynamics by “natural happening of mass disease”, into “driving force” that is causes of self moving - spontaneous genesis of epidemics: a) for mass effects of it is 'natural work' (appropriate according to another effect, with accidentally casual effect of helping of appearance of disease) which contributes coherence and consistence of contagion and man who can get disease - what will result with binary 'causative link'; while the following cause is important b) the appearance of disease: pathogenic of contagion will reflect only after previous appearance of permanent 'immanent causative link'. Reconstitution of epidemic is final act, recapitulation of familiar natural happening of concrete epidemic with anterograde chronology how the event itself happened.

After restoration of approximative cavities where gingive wall is forming subgingivaly occurs an damage of epitel of gingival sulcus and subepitel fibrous tissue. These damages occur partially in order of direct irritative effect of materials, and partially because of inadequately made definite reisen. Anomaly which may occur while making reisen, is effect of micro leakage between reisen wall of cavities roughness and reisen parts which prominate above anatomic tooth sphere , enable faster and bigger accumulating of dental plaque. Gingive inflammation is widening deeper in parodontium trough vascular network situated in interdental bone septum. Inflammation is constantly spreading from the point and reaches parodontium. The aim of this study is to estimate clinical changes in parodontium within certain group of patients of different age and sex, caused by inadequate dental restoration. Results of this research present that anomaly in dental reisen , have great influence on inflammation reaction of parodontium. Composite reisen cause higher degree of inflammatory reaction in compared to amalgam reisen

Drugs prescription and drugs accessibility are among the most important drug use related topics. A patients questionnaire was conducted in the area of Novi Sad, Bačka Palanka, Bač, Temerin and Odžak (all in South Bačka region), because the routine medical statistics does not provide all neccessary data about the drugs availability. It is demonstrated that pressure and expectations of patients and doctor-patient relationship influence the choice of drugs to be prescribed. Positive list drugs deficiency represent a great problem, forcing patients to buy drugs in private-owned stores or abroad.

Myocarditis is defined, clinically and pathologically, as inflammation of the heart muscle. The autoimmune phase is belived to play a major role and the use immunosuppressive agents may be useful in containing myocyte destruction. Aims was to systematically review the impact of Immunomodulative therapy on the outcame of severe and acute myocarditis in children. We retrospectively studied all the children admitted to University Children s Hospital with an acute viral myocarditis (AVM) from 2003-2008y. Patients were included if they had 1.severe and acute heart failure, 2 left ventricular dysfunction assessed by echocardiography, 3. a recent history of viralillness and 4. absens of personal or familial history of cardiomyopthy. Fourteen patient (37%) had severe and acute myocaditys. Seven patients were treated with immunomodulative therapy and anticongestive therapy (group I). Other seven patients were treated with anticongestive therapi only (group II). We comparred the use of antikongestiv therapy alone, with a combination of immunomodulative. Such studies have documented succeful outcome of AVM with immunomodulative trearment.

Nonsteroidal antiinflamatory drugs are currently one of the most widely used categories of drugs, because there is a huge number of indication for theirs purpose. This huge purpose of this drugs has theirs own price, which is shown in side effects, especialy in the upper parts of gastrointestinal tract: erosions of the mucose in 35-60 %, ulcers in 10-25%, strong bleeding or perforation in <1%. It is appears that this drugs are responsible for 10-20 thousands lethal outcome in the world. Even small dose of acetlisalicil acid by 75 mg,which is used in prevention of cardiovascular disease, brings to the damage of mucose GIT and 11% have ulcer. Inhibition ciklooxigen-1,which have main role in protection mucose of stomach and duodenum on the part of NAIL, lead to damage mucose GIT, and that is the result of sistemic inhibition, which is indenpendant of the way of getting drugs. Some author instigate a local effect of Nail,as week acid. It is necessary to protect highrisk pacient with using gastroprotektiv drugs

Dental caries (Caries Dentis) is multi cause, multi phase, and reversible disease of infectious nature. Modern understanding of caries etiology is showing that dental caries is complex disease as a result of numbers of factors which can be divided on causal (primary) and conditional (secondary) . According to this concept caries is an implication of local factors synergy (host-tooth, microorganisms, nutrition or substratum), as primal factors and a number of secondary factors which can react in various phases of teeth growth and function. Specific type of caries is early caries, characteristic for youngest age (suckling and infants). Early childhood caries ECC is a concept used to realistically describe emersion of all caries changes, in primal, milk dentitio , when caries exists on tooth at the least. This disease is becoming very serious health problem both in dental and medical way. And it should not be observed isolated like a dental problem but like a problem which affects overall child development. In Kosovo County, among children of age from 2 to 5, there is 96.7% of caries teeth, 2.3% of filled teeth and 0.7% of extracted teeth. Percentage of children with caries is statistically growing with age and is in range from 45.4% for a two years old, up to 77.2% for a five years old

Diabetes mellitus with one`s chronical complications is the cause of the large percent morbidites and mortality, among the population. With regard to a lot of people who have diabetes mellitus tip 2 (WHO-over 170.000.000 peoples), adequate therapy is very important. By this stady, we wont to show positive consequence new therapy for medication diabetes mellitus typ 2, chiefly application tiazolidinedion in therapy. Handlend 25 patientis with diabetes mellitus typ 2 during 3-mounth observed. Patients were divide in II groups forms on basic of the kind therapy. At the end of 3-mounth, derived results (decrease HbA1c from 7.9%±1.24% to 6.99±0.89%; data value fasting glycemia from 8.99mmol/l±2.08 mmol/l to 7.45±1.35 mmol/l, and value glycemia after meal 10.36 mmol/l±2.18 mmol/l to 8.18 mmol/l±1.31 mmol/l) indicate validity the introduction tiazolidinedion in therapy diabetes mellitus type 2.

The aim of this study was to show values of dynamometric parameters in elite athletes, and to determine and explain difference in those parameters between persons of various sport specialities and non sportsmen. In the study were included 153 participants: 123 elite athletes (17 boxers, 17 wrestlers, 27 hockey, 23 volleyball, 20 handball, 20 basketball and 19 soccer players) and 30 students, non sportsmen. Muscular strength (A) and power (P) were registrated by dynamometry. As a result of chronic adaptation to training, athletes had significantly higher values of registered parameters than non sportsmen. Lowest values of dynamometric parameters were measured in non sportsmen, at arm flexion A was 57.65 kg and power P285.60 W. Comparing results of athletes of different sport specialties, significant difference was found in values of some parameters. Dynamometric parameter at arm flexion has had the highest value in tested wrestlers 82.0kg, and lowest values were registered in soccer players, but only in absolute values. Differences in some measured parameters between groups of athletes can be explained by specific demands in different sports, during prolonged training and performance activities