Aging begins at the moment of birth and it is inevitable part of our lives. Statistical data obtained in recent years, indicate that the average human lifespan is significantly prolonged compared to the previous century, which is likely to come as a result of technological progress and consequently the development of medicine. Whole teams of scientists are constantly trying to clarify the process of aging and in some ways make it slower.Attempts to find the causes of aging is present for the purpose of extending the creative activity of man

Chronic kidney disease (CKD) is a syndrome which is caused by gradual progressive and irreversible reduction of kidney function. CKD has become a global health care problem. From a mental hygiene point of view, the aim of this study is to present the most important stressors in patients with CKD. Knowledge and recognition of everything that influences the increase of stress in people with CKD, on one hand leads to an improvement of understanding , and on the other gives us possibilities to prevent or at least reduce the negative effects of stress. Furthermore, patients with CKD often have anxiety and depressive symptoms which overlap with the clinical symptomatology of kidney disease, which is mostly caused by uremia. We have given certain suggestions for early depression screening in patients with CKD by analyzing previously conducted research. As far as diet is concerned, research suggests that patients with CKD should be prescribed a low protein diet which delays the progression of CKD, reduces the metabolical disbalance and delays the need for dialysis. A traditional diet focused on protein intake without a special selection of meals is recommended. Other recommendations are vegan diet as well as vegan diet with suplements. Furthermore, a diet without proteins with pastas without proteins, bread and other carbohydrates. There are also recommendations for a low protein diet with suplements with an intake of only 0.3 g/kg BM/protein a day with an addition of proteins from vegetables, amino and keto acids. Finally, it should be mentioned that comorbidities should be taken into consideration when prescribing a diet for patients with CKD. It is necessary for the patient to be compliant with the recommended diet.

Herpetic stomatitis as well as many other infections of the orofacial region in everyday practice represent an important percentage of pathology. These diseases can be a major problem for therapists in terms of early diagnosis and, consequently, in determining the correct treatment. The disease belongs to a group of droplet infection, caused by the herpes simplex virus, with characteristic changes in the skin and mucous membrane in children and adults. A relatively small percentage, 10-15% of primary infections are manifested with clinically distinct symptoms. At the oral mucosa occurs triad of symptoms: generalized catarrhal gingivitis, coated tongue and erosions dispersed all over oral epithelium of the oral cavity.

Standardized staging of tumors takes into account the depth of invasion of the intestinal wall and the presence of local or distant metastases, specifically focusing to precisely estimate length of patient survival. This assessment system does not fully reflect the biological behaviour of cancer individually, ie. tumor aggressiveness and ability of recurrence tumor after medical treatment. Futuremore, cancer at some patients have more aggressive growth than other carcinomas in the same clinical stage, because there are other parameters that determine the biological behaviors of colon cancer, which are not included in the standard classification of determining tumor stage. One of the recent arguments which are due in the spotlight is "tumor budding", which represents one cell or group of up to five non-differentiated tumor cells, which are found in the stroma out of the invasive front line of cancer. There are 92 colon cancer and upper rectum processed, which are collected at General Hospital in Trebinje and Medical Center in Kosovska Mitrovica. The aim is to determine whether there is a correlation between the number of tumor budding and stage of tumors in colorectal cancer. The tumor stage is determined by Astler Coller classification. Investigation, based on χ2-test, leads to the conclusion that there is not a statistical significance in tumor budding distribution in relation to tumor stage according to the Astler Coller classification (p = 0.383; p> 0.05).

As a mixed exocrine and endocrine gland pancreas has a very important role in the digestive tract. The juice of his exocrine part, which is released into the duodenum, carries more than 20 pancreatic enzymes, important for a normal process of digestion. Endocrine part of the gland, which consists of the islets-insula, actively participate in the metabolism of human organism, secreting two important hormones - insulin and glucagon. Because of its location, the pancreas is an extremely inaccessible organ for a physical examination. Despite of a large number of modern clinical methods for monitoring changes in the body, the detail knowledge of morphological characteristics of this gland is still very important. The material was taken from the cadaver of the fetus and newborn at the Institute of Pathology of the Faculty of Medicine. We classified samples of pancreas into three groups, with respect to age (from 3 months to neonates) and CS length. After dehydration and the molding compositions are cut at a thickness of between 6 and 10 microns. In addition to standard staining methods, some preparations are for identification of insula, painted by Grimelijus. In this study, we determined the morphological changes of the prenatal pancreas, from the third month of intrauterine fetal development, until the end of the fetal time and determine the dynamics of changes in the parenchyma and stroma. We could distinguish functional parts of the pancreas, in 10-11th week of development. In the first trimester of pregnancy, we have noticed an increase in parenchymal elements and the reduction of the stroma, which is slightly more pronounced in interlobular area, that clearly differentiating lobules. At the beginning of the second trimester of pregnancy, in the pancreas that are developing, we observed significant changes.The lobular structure of pancreas was clearly visible. Pancreatic acini are clearly differentiated and are in very close contact, since the stroma between them very reduced. Within almost all lobulus there are clearly expressed the islets of Langerhans, which are multiplied, different sizes, separated from the exocrine part by poorly expressed connective tissue. In the group of prematurely born children, we found that the morphology of the pancreas is very similar to the pancreas at the end of the fetal period.

Cervical cancer is one of the most common carcinomas in the female population; second in frequency. In the female population it makes up 12% of all malignant diseases. In general it takes the third place in frequency and ahead of it is the breast carcinoma and the colorectal carcinoma. Data accessed by WHO (World Health Organization) indicates that every year in the world around half a million women suffers cervical cancer, which is a significant number, of which 230.000, unfortunately, ends with lethal outcome, 83% of which comes from developing countries. In Montenegro, in 2006, 974 women died due to malignant neoplasm. In Europe, 65.000 women suffers cervical cancer, and 32.000 dies a in a year, with a significant increase in incidence and mortality in the last few years with younger population.