Introduction: Sapho syndorm is a syndrom characterizing with osteoarticular end dermatologic symptoms. Acronym „SAPHO“ means: S-Sinovitis, A-Acne, H-Hyperostosis, O-Osteytis. SAPHO syndrom has a 50 different names in existing literature. For now, etiology remains unclear, but it belongs to group of seronegative spondylarthropathies. Therapy of SAPHO includes NSAIL, glucocorticosteroids, disease modifying anthireumatic drugs (DMARD), antibiotics, bifosfonatos, and anti TNF - alfa drugs with variable success. Case outline: Pacent P.Z, 47 age, female, comes in the hospital, because of pain in anterior chest, with propagation in right arm, end morning stiffness in sacral part, which passes short after. Also, with recidivant pustules on the palms, bilaterally, which precedes itch. Bone scintigraphy was performed: There is a clear increasing binding of radiopharmacs in projection of strenoclavicular joint, and slightly in both shoulders and both knees. HP: Pustulosis palmoplantaris. We introduced in therapy azithromycin in the dose of 500 mg, two times weekly, for 16 weeks. Patient, one year after, is without relapses of arthritis and skin lesions. Conclusion: This report has goal, to get more knowledge about this rare disease, and to be easier for recognition. Also we want to introduce other physicians, of varying specialities, like orthopaedics, and other surguries, with this disease, not only rheuamatologists, dermatologists, and pediatrics.

Hepatitis A is an acute viral disease of the liver caused by the hepatitis A virus (HAV) .In many areas of the world represents a significant epidemiological problem, and the infection is usually transmitted by contact, rarely contaminated water and food. The main objective of the study was to identify the most important epidemiological characteristics of hepatitis A in Serbian areas of Kosovo and Metohija. We used the data of reporting of infectious diseases, reports on infectious diseases (seven-day, month, year) of the Department of Public Health Pristina in Kosovska Mitrovica. In our research we used epidemiological Studies of cross-section (crosssectional). Between 2003-2015. in Kosovo and Metohija (Serbian middle) registered 223 cases of hepatitis A. The average incidence in the reporting period was 11.03 / 10,0000. Analysis of age distribution revealed that the most common incidence in people aged 15-19 years, and the rarest people aged 50-59 years. Hepatitis A occurs throughout the year, showing seasonal variations. Trend of incidence shows a negative trend with a reduction in the number of cases in the territory of Kosovo and Metohija. Based on the results of our study we can conclude that hepatitis A is an important public health and socioeconomic problem. In order to prevent hepatitis A, it is important to continue to improve hygiene and sanitary conditions of life as the best general preventive measures.

Introduction: Soot usually occurs as a result of incomplete combustion of fuels containing carbon (fossil fuels - wood, coal). Air pollution is one of the most serious environmental threats to the urban population, which has harmful effects on human health, regardless of age. Objective to determine the extent to which the development of concentrations of soot in the air affects the air quality in the area tested. Methods: In the period from 2007. to 2011. the soot immission was followed at two sites: in Kosovska Mitrovica and Zvecan. The concentration of soot is determined by the reflectometric method. The statistical hypotheses were tested on statistical significance level of 0.05. Results: Overall, for both measuring points, there was a statistically significant change in value of the concentration of soot in the air (F = 6.779; p = 0.009). There was a significant increase in the concentration of soot in the air during the investigated years, with the highest values in 2010. and 2011. The average value of soot concentration for the period from 2007 to 2009 was 17.7 ± 21.3 mg / m while in the period from 2010. to 2011. it was 36.7 ± 45.2 µg/m , which represents a statistically significant difference (U = 910082.5; p<0.001). The amount of average concentrations of soot in the heating 3 3 season was 32.8 ± 44.2 µg/m while out of the heating season it was 16.8 ± 15.6 µg/m which is a statistically significant difference (U = 1030936; p <0.001). The distribution of average concentrations of soot in the air represented by month 3 showed the highest value in January at both measuring locations, in Kosovska Mitrovica 86.8 µg/m , and in Zvecan 34 3 µg/m . The total number of soot over the limit value in the period surveyed was in Kosovska Mitrovica 256 days, and in Zvecan 90 days.

Often the only available way of checking the adequacy of HD reaching dry weight after completion of dialysis treatment or monitoring arterial blood pressure. The goal of this paper is to show whether echocardiographic index measuring inspiratory collapse VCI can further assist in assessing the state of hydration of patients on HD. Method: In a study that we conducted on the UDK in Belgrade Centre for HD at 20 toro children on HD (before and after HD) and 20 healthy children, the control group. The M mode echocardiography we measured the diameter of the inferior vena cava (VCI) and calculated the index VCI inspiratory collapse. Also, accompanied by the correlation of these parameters with the dimensions of the left atrium, left ventricular in diastolic and body weight. Results: Children were before HD was significantly higher static diameter VCI and LA diameter compared to the control group (p <0.05). Index is collapsed before the HD was be substantially lower than in the control group (p <0.05). After HD LA diameter was still significantly higher than in the control group (p <0.05). while the other parameters were not statistically be substantially different. Index collapsing VCI differed significantly before and after HD (p <0.05), examining the correlation between VCI and diameter dimensions of the left ventricle during diastole (LVD) found a statistically significant positive correlation between these two parameters in all three groups of measurements (p <0.01). A statistically significant positive linear correlation was found between the VCI diameter and diameter of the left atrium (LA) in all three of measurements (p <0.01). A statistically significant positive linear correlation was found between the diameter of VCI and body weight in children after HD and control groups (p <0.01). CONCLUSION: Index collapsing and VCI in combination with other parameters can further improve the monitoring of the state of hydration and improve the quality of life of patients on hemodialysis.

Parodontopathy is a complex disease of periodontal tissues. The patological changes that occure here are destructive and lead to gradual or progressive periodontium disease and its anatomical and functional desintegration. The aim of the research was to use the PCR method (Polimerase Chain Reaction) to identify the presence and spreading of the oral pathogen Actinobacillus actinomycetemcomitans in subgingival plaque in patients suffering from the agressive parodontopathy and then compare it to qualitative-quantitaive structure of dental plaque in patients suffering from chronic parodontopathy. The study included 70 patients, average age of 45. The identification of microorganisms in subgingival plaque was determined by PCR method. In order to comfirm the diagnosis and determine the extent of destruction of periodontal tissue the standar epidemiological criteria were used: plaque index (Silness-Lӧe), gingival index (Lӧe-Silness), SBI index (Mühleman-Son) and DPP. Extremely high statictical significance of presence of A. actinomycetemcomitans was obtained in patients with agressive parodontopathy. The presence of A. actinomycetemcomitans and P. gingivalis showed the difference in distribution in patients with chronic as well as in patients with agressive pardontopathy. In our sample A.a was detected in a high percentage of younger patients with the diagnosis of agressive parodontopathy. Higher rate of A. actinomycetemcomitans in subgingival plaque has a direct impact on the course of parodontopathy. Its detection may be a useful marker for identifying the icreased risk for developing agressive parodontopathy in patients of younger population.

Introduction: Vitamin D Deficiency (VDD) is defined as the level of 25(OH)D in the serum < 30 ng/ml. According to the contemporary research, even the slight vitamin D deficiency can adversely affect our body in many ways. Numerous studies indicate that vitamin D deficiency is very common in children. The study aimed to research the frequency of vitamin D deficiency in infants and toddlers, the connection between VDD and iron deficiency anemia (IDA), as well as the correlation between 25-hydroxycholecalciferol (25(OH)D) and haemoglobin (Hb) in the examinees. Method: The study includes 150 children, 73 (49%) newborns and 77 (51%) infants. Vitamin D status was determined through the amount of 25(OH)D in blood, using the electrochemiluminescence. Results: Vitamin D Deficiency was found in 58% of infants and toddlers (severe vitamin D deficiency was found in 16% of examinees, vitamin D deficiency was found in 23% of examinees, while vitamin D insufficiency was found in 19% of examinees). Vitamin D deficiency (VDD) and anaemia were found in 80% of examined infants and toddlers. VDD was found in 49% of newborns that were not anaemic. We have observed the substantial difference between the examinees suffering from both anaemia and VDD and the examinees suffering from VDD only. Conclusion: The highest level on anaemia was found in the children with severe vitamin D deficiency, while in the examined infants and toddlers, there was a connection between the level of 25(OH)D and Hb in the serum.