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Volume 52, Issue 1, 2023

Online ISSN: 2560-3310

ISSN: 0350-8773

Volume 52 , Issue 1, (2023)

Published: 01.11.2024.

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01.01.2003.

Science Reports

SOMETHING MORE ABOUT CANCER

Until sixties of twenty centuries, it was little now abaot cancer. It was well-know than chemicals , radiation, onko viruses, can to provoke cancer.Untill seventies it was clear than cancer is not infection or inborn sicness.Than eighties discovering onko-gens (gens normal indebted for growth of cell who is mute. Understad is than cancer cell could be continue growth, and they must have onko gen ON and cancer supresor OFF. Discover so and fenomena of apoptosissuicide cell what something wrong begin.For the time of nineties thay are discover reasons of apoptosis. The main one is TP53 gen on short part of hromosoma 17, with 1179 letter. It's understand than cancer begining with muting gens what is reason of growth, continuing with muting gens what suprim growing and finish with fold of last defence muting gen TP53.In therapy of cancer is searcing for agenc who will stimulate apoptosis.Big step what genetics do on understanding cancer give us reall chance to beat cancer.

J. Živković

01.01.2002.

Professional paper

CHARACTERISTICAL BIOCHEMICAL DISORDERS DURING REYE'S SYNDROME AT CHILDREN TREATED IN PEDIATRICS CLINIC IN PRI[TINA (1991-1998).

Despite of Aspirin use in acute virus infection and reduce of incidence in many parts of the world, the Reye's syndrome is also actual in our country. Reye's syndrome was described for the first time in 1963. It's a non-inflammatory encephalopathy and lipid infiltration of liver and other organs. Etiology is unknown. Some viruses, some chemical compounds,
Aspirin and genetically abnormal answer have the role. The damage of mitochondria appears. Organism is in hard catabolism. The biochemical parameters in serum and liquor were followed at 26 children cured in treated in Pediatrics Clinic in Priština in the period from 1991-1998. The extreme hypoglycemia (<2.2 mmol/L) was in 46,1%, medium hypoglycemia
(2,3-3-,3 mmol/L) in 7,7%. Three times high transaminases appeared in 46% of children. The level of chaemostasis was reduced in 11,5% of children. Half of the total number children had the higher values of urea and creatinine. Hyperproteinorachia in liquor was 27% and hypoglycorachia was 19,3%. Metabolic acidosis was present in 61,5%. Half of the children had convulsions and pneumonia. Enterocolitis, acute renal insufficiency, anemy and urinary infection were also present.

J. Drmončić-Putica, J. Živković

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