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Lichen planus disseminatus partim vesiculosus after COVID-19 vaccine

Dragica Milosavljević ,
Dragica Milosavljević
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Milijana Relić ,
Milijana Relić
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Mirjana Stojanović-Tasić Orcid logo
Mirjana Stojanović-Tasić
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Published: 01.12.2021.

Volume 51, Issue 1 (2022)

pp. 59-62;

https://doi.org/10.5937/pramed2202059m

Abstract

Introduction: Lichen planus is an autoimmune inflammatory disease that can be associated with infections, drugs and vaccines. As concerning the potential triggering effect of vaccine, there is evidence a few cases of new-onset lichen planus that appeared after COVID vaccine, particularly the Pfizer/BioNTech vaccine. Case report: This report is a case of a newonset lichen planus triggered by the Pfizer/BioNTech vaccine administration in a healthy young female. Dermatological examination revealed polygonal, itchy, erythematous papules on trunk, upper and lower limbs, that coalesced into brownish plaques in the ankles, flexural wrist and knee. No mucosal involvement was noted. In view of the clinical picture, the timing of the skin eruption with respect to the vaccine and the histopathologic findings, a vaccine-induced lichen planus triggered by the COVID-19 vaccine has been diagnosed. Conclusion: Lichen planus or lichenoid-like eruption as a cutaneous manifestation following COVID-19 vaccines are rare, and the pathogenesis for its development is still unclear. Clinical trials showed that the leading vaccines upregulate Tcell response (Th1) and incrementing inflammatory cytokines involved in the pathogenesis of autoimmune diseases, such as lichen planus. Although we still do not completely understand its pathogenesis, dermatologists should be aware of the possibility and keep an eye out for worsening or debut of this disease after the COVID-19 vaccine. Vaccinated patients should be monitored for skin manifestations, and dermatological evaluation should be offered, when needed.

References

1.
World Health Organization: Coronavirus disease (COVID-19. 2021.
2.
Avallone G, Quaglino P, Cavallo F, Roccuzzo G, Ribero S, Zalaudek I, et al. <scp>SARS‐CoV</scp>‐2 vaccine‐related cutaneous manifestations: a systematic review. Vol. 61, International Journal of Dermatology. 2022. p. 1187–204.
3.
Bostan E, Yalici‐Armagan B. Herpes zoster following inactivated COVID‐19 vaccine: A coexistence or coincidence? Vol. 20, Journal of Cosmetic Dermatology. 2021. p. 1566–7.
4.
Temiz SA, Abdelmaksoud A, Wollina U, Kutlu O, Dursun R, Patil A, et al. Cutaneous and Allergic reactions due to COVID‐19 vaccinations: A review. Vol. 21, Journal of Cosmetic Dermatology. 2022. p. 4–12.
5.
Tan SW, Tam YC, Pang SM. Cutaneous reactions to COVID-19 vaccines: A review. Vol. 7, JAAD International. 2022. p. 178–86.
6.
López‐Valle A, Falkenhain‐López D, Ruiz‐Arranz C. Cutaneous reaction to BNT162b2 mRNA COVID‐19 vaccine. Vol. 60, International Journal of Dermatology. 2021. p. 891–2.
7.
McMahon DE, Amerson E, Rosenbach M, Lipoff JB, Moustafa D, Tyagi A, et al. Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: A registry-based study of 414 cases. Vol. 85, Journal of the American Academy of Dermatology. 2021. p. 46–55.
8.
Krajewski PK, Matusiak Ł, Szepietowski JC. Psoriasis flare‐up associated with second dose of Pfizer‐BioNTech BNT16B2b2 COVID‐19 mRNA vaccine. Vol. 35, Journal of the European Academy of Dermatology and Venereology. 2021.
9.
Karadaglić Đ. Lichen planus i lihenoidne reakcije. U: Đorđije Karadaglić, urednici. Dermatovenerologija. 2016.
10.
Lehman JS, Tollefson MM, Gibson LE. Lichen planus. Vol. 48, International Journal of Dermatology. 2009. p. 682–94.
11.
Diaz‐Guimaraens B, Dominguez‐Santas M, Suarez‐Valle A, Fernandez‐Nieto D, Jimenez‐Cauhe J, Ballester A. Annular lichen planus associated with coronavirus SARS‐CoV‐2 disease (COVID‐19). Vol. 60, International Journal of Dermatology. 2021. p. 246–7.
12.
Burgos‐Blasco P, Fernandez‐Nieto D, Selda‐Enriquez G, Melian‐Olivera A, De Perosanz‐Lobo D, Dominguez‐Santas M, et al. COVID‐19: a possible trigger for oral lichen planus? Vol. 60, International Journal of Dermatology. 2021. p. 882–3.
13.
Rosengard HC, Wheat CM, Tilson MP, Cuda JD. Lichen planus following tetanus–diphtheria–acellular pertussis vaccination: A case report and review of the literature. Vol. 6, SAGE Open Medical Case Reports. 2018. p. 2050313X1775033.
14.
Lai YC, Yew YW. Lichen planus and lichenoid drug eruption after vaccination. Vol. Dec;100(6):E6-E20. 2017.
15.
Alrawashdah HM, Al-Habahbeh O, Naser AY, Abu Serhan H, Hamdan O, Sweiss K, et al. Lichen Planus Eruption Following Oxford-AstraZeneca COVID-19 Vaccine Administration: A Case Report and Review of Literature. Cureus. 2022.
16.
Babazadeh A, Miladi R, Barary M, Shirvani M, Ebrahimpour S, Aryanian Z, et al. COVID‐19 vaccine‐related new‐onset lichen planus. Vol. 10, Clinical Case Reports. 2022.
17.
Merhy R, Sarkis A ‐S., Kaikati J, El Khoury L, Ghosn S, Stephan F. New‐onset cutaneous lichen planus triggered by COVID‐19 vaccination. Vol. 35, Journal of the European Academy of Dermatology and Venereology. 2021.
18.
Sharda P, Mohta A, Ghiya BC, Mehta RD. Development of oral lichen planus after COVID‐19 vaccination – a rare case report. Vol. 36, Journal of the European Academy of Dermatology and Venereology. 2022.
19.
Herzum A, Burlando M, Molle MF, Micalizzi C, Cozzani E, Parodi A. Lichen planus flare following COVID‐19 vaccination: A case report. Vol. 9, Clinical Case Reports. 2021.
20.
Nogueira PA, Carneiro S, Ramos‐e‐Silva M. Oral lichen planus: an update on its pathogenesis. Vol. 54, International Journal of Dermatology. 2015. p. 1005–10.
21.
Alter G, Yu J, Liu J, Chandrashekar A, Borducchi EN, Tostanoski LH, et al. Immunogenicity of Ad26.COV2.S vaccine against SARS-CoV-2 variants in humans. Vol. 596, Nature. 2021. p. 268–72.
22.
Sahin U, Muik A, Derhovanessian E, Vogler I, Kranz LM, Vormehr M, et al. COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses. Vol. 586, Nature. 2020. p. 594–9.
23.
Usatine RP, Tinitigan M. Diagnosis and treatment of lichen planus. 2011.

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