Glucagon is polypeptide hormone derived from pancreas which in addition to its metabolic actions has also certain cardiovascular stimulatory effects. We've explored the effects of glucagon on hemodynamic variables (mean arterial pressure, heart rate and central venous pressure) and on catecholamine level and the electrolite level in the kanine sera. It was estimated that glucagon expressed the positive chronotropic effect and significantly lowers the central venous pressure while inconsiderably inceases mean arterial blood pressure. It also leads to transient (short-lasting) hipokaliemia and nonsignificant hipocalcemia. As the result of the action of the glucagone, the serum adrenaline concentrations were significantly increased while the serum noradrenaline concentratios were significantly decreased

It is known that the intoxication with heavy metals and pesticides is most often unmedical poisoning. In contrast to other heavy metals, for example: mercury, lead, cadmium and zinc, toxic copper activity and the mechanism of its effect are not known enough and they are not yet explained. Because of that, the aim of this work was ( with acute dog intoxication with copper sulfate ) to contribute to better clearing of biochemical mechanism as a result of copper toxical effect and to make analysis of its tissue distribution. Researching was done on adult dogs, both sexes, different races and body mass of 14- 20 kg, who were given a 10% water solution of copper sulfate in the dosage of 33mg/b.m. divided into 5 equal doses. The analysis of biochemical blood structure took the following things: total proteins, albumins, globulins, total lipids, chole2+ sterol, glucoze, transaminase (AST,ALT), catalase, peroxidase, vitamin C, proteine SH, the contretation of Cu in the serum 2+ and the content of Cu in the tissues. The results are presented in the charts and graphic presentation. All these changes can be the important directions in an biological monitoring as a biochemical indication of copper pollution in the surroundings.

The complement system (complement) involves over 30 circulating and membrane-fixed proteins with an effector
role in the innate and humoral immunity. These proteins help the function of antibodies to protect the organism from foreign
molecules (antigens) which the term complement comes from. Soluble proteins of the complement system made mainly in
the liver and circulate in blood in an inactive form. The activation of complement may be initiated in three ways (classical,
alternative and lecitin pathway), and it is realized by sequential proteolysis of complement proteins (proenzymes) which
become emzymes with the proteolitic activity after cleavage. Products of the activatin of complement bind to the surface of
microbes or to the antibodies bound to antigens. An activated complement shows a number of biological effects, such as
lysis of an attached cell, opsonization, neutralization of viruses, inflammation, clearance of immune complexes etc. In contrast of microorganisms, human cells have a number of regulatory proteins which prevent the complement activation and in that way, they regulate its activity

Scientific research of effects of glucagon on the cardiovascular system have shown that glucagon has some
cardiostimulatory potential. The very interesting fact is that glucagon shows its cardiostimulatory effects by activating its
own, higly specific glucagonic receptors. That is way we wanted to research not only the effects of glucagon on the C.V.S.
but also its effects during the depression of the C.V.S. with high dosses of beta blocators (presolol) expecting a good
hemodinamic response. The experiment has been performed on two groups of 6 dogs. The first group of animal was treated
with i.v. bolus injections of glucagon and other group with presolol (15 mg/kg b.w.) i.v., and after that with i.v. bolus
injection of glucagon. Hemodinamic variables (mean arterial pressure, central venal pressure and hearth frequency) were
registred at the 1-st, 2-nd, 3-rd, 10-th, 20-th, 30-th and 40-th minute. The hearth frequency was registred by continous
monitoring, mean arterial pressure was registred with cateter in the arterial femoralis, while the central venal pressure was
registred over central venal cateter in v. femoralis. After the i.v. bolus injection glukagon shows higly positive effects,
followed by short-term increase of the mean arterial pressure, while the c.v.p. considerably falls. During the administration
of presolol the hearth frequency and mean arterial pressure fall considerably and progressively, while the c.v.p. rises
considerably. Glucagon, in conditions of c.v.s. depresion by high doses of presolol (15 mg /kg b.w.) considerably increases
hearth frequency and mean arterial pressure, while the c.v.p. falls considerably.

With this work we intended to examine antipyretical effect of different extracts from the leaf. The following extracts were examined: etherical chloroformic The experiments were conducted on white laboratory mice, type BALB/C. Mice were divided in 5 groups, where each group received the appropriate extract. Rectal temperature was measured by "Termistorowy" termometer. After the temperatures were measured, for each of examined group we defined area under the curve. The area values were later used to determine statistically significant differences between them. Examination results of antipyretic effects of different extracts ( ) from the leaf, i parsley (Et O), (CHCl ), ethyl-acetic (EtOAC), n-bhutanolic (nBuOH), aquae- 2 3 ous (H O). 2 etherical (Et O), chloroformic (CHCl ), ethyl-acetic (EtOAC), n-bhutanolic (nBuOH), aquaeous (H O) parsley 2 3 2 n experiment with mice, show that all the extracts mentioned above, decreased (annuled) pyrogenic effect of 12% yeast suspension. 

In this research it was examined how fatigue in the working process affected the speed of reaction on a complicated
stimulus, and also on the frequency of inadequate reactions. The investigation was carried out by means method of combine
reaction time (CRT). CRT is the shortest time that passes from the moment when a person is affected by a complicated stimulus until the moment when the person responds to the stimulus, by making adequate and complicated reaction. CRTwas registrated in working population of railroad employees who were divided in two groups:group of locomotive drivers (n= 44) and group of a railroad employees (n=25). In the group of locomotive drivers it was taken into the consideration whether the type of locomotive was electrical or diesel power. In both groups, CRT was registrated in two phases of working process; before and after daily work. Results showed that in both examined groups CRT got significantly extended after the
working process. Duration of CRT was longer before and after working process in the group of electrical power locomotive
drivers compared to diesel power locomotive drivers. Fatigue did not affect significantly on the frequency of incorrect answers

Planning daily activities, depending on neurophysiological chronotipology, is one of the steps, which should be taken towards the more successful, healthier, high quality life. Aperiod of time within a day during which the individuals of both sexes, different age and profession are intellectually the most optimally efficient, was determined in the paper. The chronotype of a given person was taken into account for that purpose. The research was carried out using a questionnaire. The questioned individuals were divided into four groups: 120 students at the University of Novi Sad, 50 professors at the University of Novi Sad, 50 railway workers and 50 female civil servants employed in administration. The obtained results show the following: the highest percentages of students belong to the morning chronotype. They sleep more than professors do and the optimal time convenient for mental and heavy physical work is from 11 AM to 1 PM. This data should be taken into account while planning student tests. The University professors, both male and female, belong to the morning chronotype. The female professors sleep more than male professors, but are psychologically and physically optimally productive at the same time as the male professors, from 8 AM till 10 AM. In the group of railway workers, the most common are individuals of indifferent chronotype. The highest percentage of women employed in administration belong to the morning chronotype and for their optimal psychological activity they choose the period of time between 8 and 10 AM, as well as the railway workers. According to the opinion of most people that have been questioned, among all of the abovementioned groups, the optimal five-hour working period should begin at 8.30 AM.