Diabetes mellitus is a typical example for connection betwen sickness of internal organs and the skin. The ratio betwen glycose level in a gram of skin and the amount of glycose in a mililiter of blood is higher in diabetes mellitus then normal. This implies that insulin regulates intracelular distribution of glycose in the skin. It is recessary for the keratinocyt growth and diferentiation, healing of wounds, but also for the fibroblast functioning in the derm. In diabetes mellitus acidofil is lowered, and glycolised colagen is increased, and fibroblasts in the extra produce fibronectin. Skin and visible mucosys infections caused by candida albicans in diabetes patients belong to the group of deseases that could be a consequence of a disbalanced metabolism. They are seen frequently, but not patognomic for these patients, becuse they are also possible in people whose metabolism is normal. Badly controlled or undiagnosed dibetes mellitus is often coupled with candida induced skin deseases. Sometimes candida infections are the first sign of diabetes. Dermatologist is often in position to discover the disease on the basis of skin symptoms, which gives possibility for regulation of the sickness on time and avoid complications. It is known that complications develop slower when diabetes is regulated. Skin alterations in candidiasys and its connection with diabetes are described briefly, with an attempl to explain patogenesys of their apearence.

Haemodialysis, as a drastic medical procedure, needs a modern technology for performing of qualitative depurative process. Trying to imitate a function of healthy kidneys, it provides survival without one vital organ. The aim of the study was a qualitative estimation by comparing laboratory and clinical parameters of one-year haemodialysis treatment with different dialysis methods. In all patients treated with chronicle haemodialysis in Dialysis Centre in Kosovaska Mitrovica, we performed a set of laboratory analyses, recorded hepatotrophic viruses and determined a quality of haemodialysis by the degree of urea elimination. There are 16 patients on chronicle haemodialysis, 11 female (68,75%) and 5 male (31,25); mean age, 52,46±16,89 years, mean time on dialysis was 58±51,835. An increase of hemoglobin concentration was correlated with bicarbonate heamodialysis initiation. (61,692±19,405 vs. 75.466±13,814; p=0,038). Cholesterol (5,32±1,522 vs. 4,34± 1,006; p=0,0481) and inorganic phosphorus (1,427±0,2327 vs. 1,692±0,260; p=0,0056) are biochemical factors that are in a reverse correlation with bicarbonate haemodialysis in our patients. The degree of urea elimination as a measure for haemodialysis adequacy was statistically significant indicator of an adequate dialysis and was correlated with bicarbonate haemodialysis initiation (t=8,571; df=1; p=0,0389)

Diabetes is the most common cause of end-stage renal disease .in United States , Europa and Japan. Approximately 40% of patients with type 1 diabetes and 5-15% of patients with type 2 diabetes eventually develop end-stage renal disease. Risk factors for development of diabetic nephropathy include hyperglycemia, hypertension, positive family history of nephropathy and hypertension, and smoking. Key elements in the primary care of diabetes include glycemic control, blood pressure control, and screening for microalbuminuria. In general, the goal for glycemic control is a blood glucose level as close to normal (HbA C <7%) . Blood pressure control is at least as important as glucose control, especially after the onset of 1 renal damage, and blood pressure should be consistently <130/85. Screening for diabetic nephropathy involves monitoring at least yearly for urinary albumin excretion >30 mg per day. Microalbuminuria is defined as the urinary excretion of 30300 mg of albumin per day. Both glycemic control and rigorous control of blood pressure have significant impact on prevention and progression of diabetic nephropathy. Identification of patients with microalbuminuria selects a population of patients with increased mortality. Microalbuminuria screening should begin at the time of diagnosis. ACE inhibitors should be used when microalbuminuria is present regardless of the presence or absence of hypertension in type 1 diabetes and are widely.
used in normotensive patients with type 2 diabetes, as well.The effect of ACE inhibitors is probably not only via lowered
systemic blood pressure but also via direct effects on intraglomerular hemodynamics. 

In this work we have examined echocardiographic characteristics of left ventricle in patients with acute myocardial infarction (AMI). We used prospective study, during 12 months, and we followed 55 patients with diagnosed non Q AMI. All patients were hospitalized in the Coronary unit. Results: 55 consecutive (40 males middle age 55,4±8,7 and 15 females middle age 57,4±10,3) had non Q AMI. Value of ejection fraction: after 4.day - 50,4±6,2% ,2.weeks - 54,6±5,8%, 4. weeks - 59,3±5,4%. Value of ejection fraction in patients with thrombolytic therapy: 61,6±6,8% vs. 57,3±6,6% p> 0,05;Value of left ventricle fractional shortening: 28,8±2,5% (in patients with thrombolytic therapy 30,3±4,8% vs.27,2±5,9%) Value of end2 2 2 - diastolic volume: after 4.day- 62,5±5,3 ml/m , 2.weeks - 63,1±5,4 ml/m , 4. weeks - 64,4±5,8 ml/m (in patients with throm 2 2 2 bolytic therapy 60,5±9,2 ml/m vs. 67,4±8,4 ml/m ) Value of endsistolic volume: after 4. day - 26,2±2,1 ml/m , 2.weeks2 2 26,8±2,3 ml/m , 4. weeks - 27,6±2,2 ml/m (in patients with thrombolytic therapy 25,6±2,8 ml/m2 vs. 31,7±3,1 ml/m2 p> 0,05). During the in-hospital follow up period, 2(3,6%) patients and during the post-hospital follow up period, 1 (1,9%) patients with non Q AMI had lethal outcome.

Pruritus is one of the commonest symptoms of dermatologic appearances in uraemic syndrome and it occurs in 90% of patients on dialysis with different etiology and pathophysiology. The aim of the study was to estimate the frequency of uraemic pruritus and the comparison with clinical and biochemical parameters in 124 patients treated by chronicle haemodialysis at Department of Haemodialysis, Urology and Nephrology Clinic, Clinical Center “Kragujevac”. The routine laboratory analyzes were carried out in examined patients and the concentration of parathyroid hormone was determined. The study was based on data from history of disease and  questionnaire carried out in all patients. Of 124 patients, 65,3% were male and 34,7% were female, mean age of 55,98±12,94 years; the mean time on HD was 55,5 ±50,4 months. 46,8% of examined patients had symptoms of uraemic pruritus. Uraemic syndrome and uraemic complications, manifested by the concentration of urea, 21,57±7,56 vs. 22,93±5,754; p=0,05 and time on dialysis, 67,27±60,07 vs. 43,64±36,84; p=0,02, are the significant parameters of uraemic pruritus. Serum concentration of iron 15,16±8,03 vs. 11,73±6,21; p=0,05 and UIBC 25,12±10,6 vs. 30,45±9,86; p=0,04, as well as hyperglycemia 6,16±2,516 vs. 6,82±2,872; p=0,02 are significantly correlated with uraemic pruritus. There was a statistically significant difference in albumin concentration 35,84±9,09 vs. 37,72± 3,105; p=0,05 but our results were reverse to the data in literature where the reported albumin level was higher in patients with uraemic pruritus. 27,6% of examined patients had itching of all the body what is in correlation with literature. Between the patients with localized itching and patients with generalized itching, there are statistical significance in following: number of erythrocytes 2,4±0,96 vs. 2,7±0,6; p=0,02, concentration of hemoglobin 78,53±31,44 vs. 89,36±19,81; p=0,05, hematocrit 0,23±0,089 vs. 0,26±0,057; p=0,02 and TIBC 29,45±12,01 vs. 34±4,86; p=0,02, as well as concentration of glycemia 5,38±2,52 vs. 6,42±2,12; p=0,01.

A chronic hyperglicemia with diabetes leads to damage, disfunction and physiology disorders in various organs and tissues so the skin changes are occuring frequently. They are serious and are early discovered. The importance of knowing the bacterial skin infection with diabetes patient is in the fact that sometimes they can be markers and be preceded of the manifestation of the diabetes during the years i.e. in the prevention of the complications even though the glucose tolerance is limited. Then, any increase of the glucose level should be considered patological. Acute and chronic bacterial skin infections can change the regulation of diabetes which may lead to worse metabolic regulation with diabetes patients. The bacterial skin infections belong to the infection group that according to the clinical experience more frequently appear
in diabetes. But a close connection with diabetes is not proved. This study aims to point out the bacterial skin infections with diabetes patients. The results of our study indicates that bacterial skin infections are more frequently represented with diabetes patients (11.0%) than with the persons without Diabetes mellitus (4.8%).

Diabetes mellitus is the most frequently chronical disease.In the relation on the degree of affection populations (over 150 000 000 peoples), was able speak about pandemic of this illnesses. In the orgin of insulin-indipendent diabetes mellitus, the primary role has the insuline resistence. Date from literature gives the evidence that the metformin is a drug for insuline resitence. Behaind the rest, has been proved that metformin, decrease risk factors for beginning complications this illnesses

The aim of our work was to inquire characteristics of myocardial infarction in diabetic patients.We questioned
prospectively 441 patients, diagnosed with acute myocardial infarction. Diabetes mellitus (DM) was found in 31,3%
patients. Atrial fibrillation was found in 16,7% patients with DM and 7,3% on patients without DM(p<0,05).Ventricular
arrhythmias gr.III was found in 18,8% patients with DM and 15,8% on patients without DM (p>0,05), gr. IV 24,6% vs.
12,9% (p<0,05) and gr.V 18,1% vs.9,9% (p<0,05). Heart failure (NYHA I) was found in 10,9% patients with DM and
10,6% on patients without DM (p>0,05), heart failure NYHA II 13,8 vs.10,6% (p>0,05), heart failure NYHA III 14,5% vs.
5,6% (p<0,05) and heart failure NYHAIV 10,1 vs. 3,3% (p<0,05).Cardiogenic shock was found in 21,7% patients with DM
and 10,2% on patients without DM (p<0,05). QRS scor was found 8,3+-2,9 in patients with DM and 4,5+-1,5 on patients
without DM (p<0,05). In-hospital mortality was found 20,3% in patients with DM and 8,2% on patients without DM
(p<0,05). Post-hospital mortality was found 10,2% in patients wuth DM and 5,1% on patients without DM (p>0,05).
Myocardial infarction in patients with DM have difficulty clinical flow and higher mortality

The retrospective study included all patients treated at Clinical Centre in Kragujevac, who needed an acute HD treatment due to vital endangerment, during 2003. The objective of this study was to demonstrate our experiences in treating these patients using central venous catheter. The results of this study show that femoral catheters are dominant (over 95%), with slight using of jugular and subclavial catheters (5%), in spite of the recommendation of the American Association for Renal Diseases to use femoral catheters only for patients supposed to be in hospital during the interval of 5 days. The
frequency of infections in our study (16,6%), coincides with the data of the American Association for Nosocomial Infections (NNIS)[1] (17,8% catheter infections). Gram-positive bacterium from Staphylococci group are the most frequent cause of catheter infections also in our patients

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Diabetes mellitis,type 2 is often associate with disorders metabolism of lipid. That is base for development athero sclerosis, coronare disease and peripheral vascular complications. Patient with diabetes earlier get cariovascular disease. Frequency in equllent in female and male sex. Atherosclerosis is proces which is started earlier in patiens with diabetic, than in healthy population. So, prevention of cardiovascular disease is very important. When we elimination risk factors: smoking, hypertension and lipids, we will reduce coronary syndrome.The clinicly studies show us that the statins drugs are choice for prevention and controle metabolism lipids in these pations. Statins drugs had been show us the best therapy the efects on evolution of atherosclerosis plaques, reversed endothel disfunction and modulation of thrombotic parametars