The purpose of this study was to evaluate the effect of aspirin and ticlopidine, administered alone and in combination, on liver function parameters. The experiment was conducted on white laboratory rats, type Wistar. Thirty-two rats were divided in four groups and they recived one of the following treatments for 4 days: group I, control, saline (1 ml/kg, i.p.); group II, aspirin (50 mg/kg/day i.p.); group III, ticlopidine (125 mg/kg/day i.p.) and group IV, aspirin+ticlopidine combination (50 mg/kg/day+125 mg/kg/day i.p.). After the treatment the animals were anaesthetised with ether and blood for further analyses was taken by cardiopunction. The total cholesterol serum level was significantly increased only in ticlopidine group in comparison to control (p<0.01).Also, the serum activity of alkaline phosphatase and total bilirubin concentration were significantly elevated only in ticlopidine treated group (p<0.001). Serum AST and ALT activities were not significantly elevated in all treating groups. On basis of the obtained results it can be noticed that the values of liver function parameters are greater in group treated with ticlopidine than in group treated with ticlopidine and aspirin combination.

In regulation of specific immune responses the most important role play interleukin-2, IL-4, IL-5, IL-13, inter feron- (INF- ), transforming growth factor- (TGF- ) and lymphotoxin (LT). These signal molecules are produced mainly by T-lymphocytes after recognition of foreign antigens by specific receptors (TCR) placed on plasmalema. Some of mentioned cytokines stimulate proliferation and differentiation of various lymphocyte populations in the activation phase of T cell-de pendent immune responses, while the others activate and regulate the function of specialized effector cells, such as mono nuclear phagocytes, eosinophils, and neutrophils, to eliminate antigens in the effector phase of immune responses. In con trast to most of cytokines which have stimulating action on an initiation and course of humoral and cell-mediated immune responses, TGF- has an inhibitory effect on the activation and proliferation of T-lymphocytes and the other leukocyts

Stress ulcer presents acute lesion of gastric mucosa, which resulted from influence of different stressors: trauma,
shock, burns, drugs administration, various irritants etc. Since pathogenesis of stress ulcer is not completely clarified, the
most adequate therapy for the patients which suffer from it, is not defined yet. Esomeprazole is a S-isomer of omeprazole
and is the first inhibitor of proton pump synthesized as an isomer. Our aim was to test effects of esomeprazole, given during
pretreatment and posttreatment period, on progress of alcohol induced stress ulcer lesions. We had experiments on sexually
mature Wistar rats weight 200-250 g. Alcohol stress was induced by intragastric administration of 1 mL 96% alcohol.
Alcohol stress produced massive submucosal lesions in glandular part of stomach. Macroscopic lesions were verified
histologicaly. Intragastric pretreatment administration of esomeprazole (20 mg/kg BW) significantly (p<0,001) reduced gastric lesions. Intragastric post-treatment administration of esomeprazole (20 mg/kg BW) did not reduce gastric lesions. Esomeprazole (20 mg/kg BW) administrated in pretreatment period of alcohol induced stress significantly decreased dimensions of stress ulcer lesions in rats, while the same dose administrated in posttreatment period did not cause that effect.

The complement system (complement) involves over 30 circulating and membrane-fixed proteins with an effector
role in the innate and humoral immunity. These proteins help the function of antibodies to protect the organism from foreign
molecules (antigens) which the term complement comes from. Soluble proteins of the complement system made mainly in
the liver and circulate in blood in an inactive form. The activation of complement may be initiated in three ways (classical,
alternative and lecitin pathway), and it is realized by sequential proteolysis of complement proteins (proenzymes) which
become emzymes with the proteolitic activity after cleavage. Products of the activatin of complement bind to the surface of
microbes or to the antibodies bound to antigens. An activated complement shows a number of biological effects, such as
lysis of an attached cell, opsonization, neutralization of viruses, inflammation, clearance of immune complexes etc. In contrast of microorganisms, human cells have a number of regulatory proteins which prevent the complement activation and in that way, they regulate its activity

Scientific research of effects of glucagon on the cardiovascular system have shown that glucagon has some
cardiostimulatory potential. The very interesting fact is that glucagon shows its cardiostimulatory effects by activating its
own, higly specific glucagonic receptors. That is way we wanted to research not only the effects of glucagon on the C.V.S.
but also its effects during the depression of the C.V.S. with high dosses of beta blocators (presolol) expecting a good
hemodinamic response. The experiment has been performed on two groups of 6 dogs. The first group of animal was treated
with i.v. bolus injections of glucagon and other group with presolol (15 mg/kg b.w.) i.v., and after that with i.v. bolus
injection of glucagon. Hemodinamic variables (mean arterial pressure, central venal pressure and hearth frequency) were
registred at the 1-st, 2-nd, 3-rd, 10-th, 20-th, 30-th and 40-th minute. The hearth frequency was registred by continous
monitoring, mean arterial pressure was registred with cateter in the arterial femoralis, while the central venal pressure was
registred over central venal cateter in v. femoralis. After the i.v. bolus injection glukagon shows higly positive effects,
followed by short-term increase of the mean arterial pressure, while the c.v.p. considerably falls. During the administration
of presolol the hearth frequency and mean arterial pressure fall considerably and progressively, while the c.v.p. rises
considerably. Glucagon, in conditions of c.v.s. depresion by high doses of presolol (15 mg /kg b.w.) considerably increases
hearth frequency and mean arterial pressure, while the c.v.p. falls considerably.

With this work we intended to examine antipyretical effect of different extracts from the leaf. The following extracts were examined: etherical chloroformic The experiments were conducted on white laboratory mice, type BALB/C. Mice were divided in 5 groups, where each group received the appropriate extract. Rectal temperature was measured by "Termistorowy" termometer. After the temperatures were measured, for each of examined group we defined area under the curve. The area values were later used to determine statistically significant differences between them. Examination results of antipyretic effects of different extracts ( ) from the leaf, i parsley (Et O), (CHCl ), ethyl-acetic (EtOAC), n-bhutanolic (nBuOH), aquae- 2 3 ous (H O). 2 etherical (Et O), chloroformic (CHCl ), ethyl-acetic (EtOAC), n-bhutanolic (nBuOH), aquaeous (H O) parsley 2 3 2 n experiment with mice, show that all the extracts mentioned above, decreased (annuled) pyrogenic effect of 12% yeast suspension.