Neuropatski bol predstavlja kompleksan klinički sindrom koji nastaje kao posledica oštećenja ili bolesti somatosenzornog sistema, bilo na perifernom
 ili centralnom nivou. Karakteriše ga prisustvo bola bez spoljašnjeg nadražaja ili dugo nakon što je povreda prošla. Obično je hroničan, a pacijenti ga
 opisuju kao žarenje, peckanje, probadanje ili mravinjanje. Etiološki spektar neuropatskog bola je širok i obuhvata različite nozološke entitete:
 dijabetes melitus (dijabetička polineuropatija), postherpetičnu neuralgiju, centralne vaskularne lezije (moždani udar), traumatske povrede, multiplu
 sklerozu, tumore i jatrogene uzroke poput hirurških oštećenja nerava.  
Cilj ovog rada je da se, na osnovu važećih kliničkih smernica, najnovijih naučnih saznanja i praktičnog kliničkog iskustva, sistematizuju aktuelni
 principi u dijagnostici i terapiji neuropatskog bola. Sprovedena je ciljana analiza savremene literature dostupne u bazama PubMed, Scopus i Cochrane
 Library, sa fokusom na savremene dijagnostičke i terapijske aspekte neuropatskog bola. 
Lečenje neuropatskog bola zahteva individualizovan, multimodalan pristup, koji obuhvata farmakološke i nefarmakološke intervencije. U
 farmakoterapiji se preporučuju četiri glavne grupe lekova: triciklični antidepresivi (npr. amitriptilin), inhibitori ponovnog preuzimanja serotonina i
 noradrenalina (duloksetin), antiepileptici (gabapentin, pregabalin) i opioidi (kod rezistentnih oblika). Lokalne terapije (lidokain, kapsaicin) i
 invazivne metode (npr. neuromodulacija) u određenim kliničkim kontekstima. 
Uprkos napretku u razumevanju mehanizama nastanka neuropatskog bola, terapijski odgovori su često suboptimalni. Stoga je ključno insistirati na
 personalizovanom pristupu, koji integriše preciznu dijagnostiku i racionalnu farmakoterapiju. Pravovremeno prepoznavanje i pravilno razumevanje
 patofiziologije ovog bola predstavljaju osnovu uspešne terapije i očuvanja kvaliteta života pacijenata.
 Ključne reči: neuropatski bol, dijagnoza, terapija, multimodalni pristup.

The emergence of brain infarction depends to a great extent on the status of collateral blood circulation and is associated with hemodynamic instability. This kind of brain infarction is usually found in border vascular zones. Infarction of borderline fields arises between vascular territories ACA and ACM or between ACM and ACP, deep paraventricular infarcts in internal border zones, wound or triangular cortical infarcts, as well as major infarctions involving the entire irrigated territory of ACM.

A case of a patient is shown, who was admitted for neurological exploration, with clinical manifestations of the cerebrovascular accident in the posterior circulation (TIA V-B vascularisation). In accordance with diagnostic protocol, an endocranial CT was performed. The results of the brain CT indicated an existence of an alteration in the right pontocerebellar angle area, which was subsequently diagnosed as a n. vestibularis schwannoma in an NMR examination. After a neurosurgical deliberation, the patient was treated with a gamma knife. After this surgery, which was done in a local anesthesia, the patient's condition was well and he was discharged. Control examinations have shown minor difficulties during the stimulation of the left ear auditive structures. Control examinations involving NMR showed no signs of recidivate focal findings.

Arachnoid cysts are cavities filled with liquor, usually localized on the floor of the middle cranial fossa. Clinically, they are usually asymptomaticand can sometimes be presented with increased intracranial pressure syndrome and epileptic seizures. We present a patient who, after a slight head injury in a accident develops an increased intracranial pressure syndrome followed by an epileptic seizure. Based on the clinical course and diagnostic processing, we want to draw attention doctors who are in a position to inspect these patients that apparently slight head injuries can be complicated and dangerous for the lives of the premorbid intracranial condition of the injured.