Conclusion about efficacious of some medication can be given based on reducing morbidity and mortality in patients treated with that medication.. Aim of this work was to estimate intrahospital mortality in patients with acute myocardial infarction (AMI), role of myocardial reinfarction in that and side effects of medications in patients who were different treated in initial phase of AMI, based on what they were separated in three different therapeutic groups: group treated with thrombolytic therapy, group treated with beta-blockers and group treated with nitrates. It was shown that intrahospital mortality is highest in patients treated with nitrates but there was not significant difference between thera-peutic groups in frequency of myocardial reinfarction while frequency of complications and side effects were in range as in others similar studies.

Heart insufficiency is frequent and important complication of acute myocardial infarction (AMI). Aim of this work was to estimate frequency, haevyness and course of heart insufficiency in patients with AMI who were different treated in initial phase of AMI, based on what they were separated in three different therapeutic groups: group treated with thrombolytic therapy, group treated with beta-blockers and group treated with nitrates. It was shown that time of admission and condition of patient in moment of admission is the key factor for choise of therapy but using of therapy making less frequency and heavyness of heart insufficiency while for cases with most difficult forms of insufficiency of heart as a pump thrombolytic therapy is practically only posible choice

Besides big improvement of diagnostic, therapeutic and preventive procedures vascular disease generally and vascular disease of brain remain of biggest importance in total morbidity and mortality. This examination included patients in Urgent Surgery Center “Simonida” Gracanica. In article is represent relationship between brain and heart dysfunctions and it is obvious that cerebral disturbances can cause heart disturbances and also it can be in opposite direction. Well, based on this is very important to make fast and correct orientation: CARDIOCEREBRAL or CEREBROCARDIALSYNDROME. In diagnostic procedure and therapeutic treatment is necessary cooperation between cardiologist and neurologist because in most of these cases we have cardiocerebral or cerebrocardial syndrome. Better treatment patients with brain stroke claim teamwork different specialist.