Abnormal liver function tests occur in 3-5% of pregnancies, with many potential causes, including coincidental liver disease (most commonly viral hepatitis or gallstones) and underlying chronic liver disease. Pruritus in pregnancy is common, affecting 23% of pregnancies, of which a small proportion will have obstetric cholestasis. Intrahepatic cholestasis of pregnancy (ICP) is a cholestatic disorder characterized by pruritus with onset in the second or third trimester of pregnancy, elevated serum aminotransferases and bile acid levels, and spontaneous relief of signs and symptoms within two to three weeks after delivery. ICP is observed in 0.4-1% of pregnancies in most areas of Central and Western Europe and North America. Genetic and hormonal factors, but also environmental factors may contribute to the pathogenesis of ICP. Intrahepatic cholestasis of pregnancy increases the risk of preterm delivery (19- 60%), meconium staining of amniotic fluid (27%), fetal bradycardia (14%), fetal distress (22-41%), and fetal loss (0.4-4.1%), particularly when associated with fasting serum bile acid levels >40 μmol/L. Important ICP-induced changes in serum profiles of amidated bile acids were observed, involving both a marked increase in cholic acid concentration and a shift towards a higher proportion of taurine-conjugated species. Ursodeoxycholic acid (10-20 mg/kg/d) is today regarded as the first line treatment for intrahepatic cholestasis of pregnancy. Delivery has been recommended in the 37-38th week when lung maturity has been established.

Its analyzed from a epidemic figurante aspect. The childrens department, health headquarters from Kosovska Mitrovica in the year of 2007. They were able to bring 748 children for healing. Down North Kosovo, they had 81% of children and another 7% from the village Priluzje and Plementina come. There was a increase in the number of incoming children in January and Febuary. And then the same time, in september and October. Half of the healed childrens age varies up to 2 years old. In a period of 6 days, they are able to heal 72, 6% of children. In the 94 stuctured diagnosises, they were able to show all the morbidity. Dominating sickness of the respitory system, in the winter season. And the digestive system in the fall season.

In two refugee camps, near K.Mitrovica (in little colliery city), gipsys refugees dislodge by Albanians were temporary located. In their blood, lead contamination is discovered. All together 310 children, 1-14 years old, were contaminated by lead. Examination and treatment is implement by the SZO patronage, which took capillar blood samples from 298 children and vein blood samples from 190 children. Level of lead, in 47 cases was more then 45 microgram./dl. All the children with high level of lead had physical and laboratory tests. Also, they were under special food diet, with a lot of calcium. In 45 cases, per os treatment is used with “Chemet” medication, produced by McNeil-USA.Only in 9 cases, week bad reaction was notice using this medication. In some isolated cases, headache, pain in stomach, sickness and sleepiness. This difficulties didn't required therapy cancelation. Treatment was fully successful except in two cases, where therapy was repeated.