Defined daily dose (DDD) is arbitrary chosen technical unit for measuring medicament usage and it is not a recommended therapeutic dose. It is in fact a statistical parameter for monitoring medicaments usage, and it is related to the
dose which is usually prescribed for the indication that the medicament was registered for. The aim of this work is to perform a detailed analysis of the extent and structure of the region of South Backa. According to the obteined data, medicaments
used in treatment of gastroinestinal tract contributed with 15.52 DDD/1000 inhabitants per day. Most commonly used are antacids and anti-ulcer drugs (8.14 DDD/1000 inhabitants per day). Medicaments used in treatment of muscular and skeletal
system contributed with 14.30 DDD/1000 inhabitants per day. Antiinflammatory and antirheumatic drugs sre used in amounts of 14.18 DDD/1000 inhabitants per day. In our country there is no complex survey of drug usage because there is no way of monitor ing which could apprehend all possible information sources. Defined daily dose is not introduced into practical qualitative and quantitative monitoring. It is necessary to make systematic network of information sources to provide for insight into medicament usage

Defined daily dose (DDD) is arbitrary chosen technical unit for measuring medicament usage and it is not a recommended therapeutic dose. It is in fact a statistical parameter for monitoring medicaments usage, and it is related to the dose which is usually prescribed for the indication that the medicament was registered for. The aim of this work is to perform a detailed analysis of the extent and structure of the region of South Backa. Antiinfective medicaments in systematic use, according to the obtained data, participate with only 7.96 DDD/1000 inhabitants. The most applied pharmacotherapeutic subgroup with 2.99 DDD/1000 inhabitants is comprised of cephalexine and cephachlor. 

The research was conducted at the Department of Pathology and Histology of Clinical center of Novi Sad. We analysed the reports of autopsies of newborns (to 28 days old), stillborns and miscarried fetuses in 1991 and 2001. Found
malformations were classified according to organ systems. Results for 1991 show next structure of congenital malformations: 3 malformations of central nervous system (14.29%), 0 malformations of urogenital system (0%), 3 malformations of
gastrointestinal system (14.29%), 1 malformations of musculosceletal system (4.76%), 9 malformations of cardiovascular
system (42.86%), 1 chromosomal defects (4.76%), 4 multiple malformations (19.05%). Results for 2001 have next value: 9
malformations of central nervous system (27.27%), 4 malformations of urogenital system (12.12%), 5 malformations of
gastrointestinal system (15.15%), 0 malformations of musculosceletal system (0%), 4 malformations of cardiovascular
system (12.12%), 2 chromosomal defects (6.06%), 9 multiple malformations (27.27%). By the comperison of the results of
structure of congenital malformations in 1991 and 2001, we can conclude that the differences of cardiovascular and urogenital malformations are statistically important

Reduced glutathion (GSH), glutathion-reductase (GR) and glutathion-peroxidase (GSH-Px) are significant indicators of oxidative stress. Oxidative stress is a consequence of increased production of reactive oxygen radicals and/or on the other hand, insufficient antioxidative protection. It is well-known that free radicals have key role in the large number of biological phenomena, such as differentiation, transformation, signal transduction, aging etc., and they are important factors in pathogenesis of various diseases (carcinoma, diabetes, Alzheimer, Parkinson, aterosclerosis). This paper presents results of investigation of content of GSH and activities of GR and GSH-Px in healthy patients and diabetes insulindependent patients between 20 and 75 years of age in the region of Indjija. Correlation between investigated parameters in healthy persons and diabetics was found, as well as with results of similar investigations in other countries. Investigated sample comprised 200 healthy patients (20-75 years) divided into 5 groups, and 80 diabetes patients divided into 4 groups. Every group consisted of equal number of males and females. Above mentioned parameters were determined in hemolysate. Parameters change depending on patient age, and changes are more intense in all patients. Some differences exist in correlation of our results with results obtained in other regions.

Hiposmia or anosmia are common cases after infections. The virus of influenza is most common cause of anosmia
and hiposmia. In a cause of hiposmia and anosmia which are the results of influenza it is need to start with regular and actual theraphy, or in other case anosmia or hiposmia are permanent.