Disturbances of thyroid function are often accompanied by cognitive and affective disorders. Assessment of cognitive status in the patients with subclinical hypothyroidism represents a possibility for early diagnostics of cognitive impairment and timely introduction of necessary pharmacotherapy treatment. The aim of this study was to quantify whether there are P3 event related potential (ERP) deviations as electrophysiological markers of cognitive activity in patients with subclinical hypothyroidism. P300 potentials were examined in thirty patients with subclinical hypothyroidism and in 30 healthy subjects of the control group. P300 was recorded using the classic auditory oddball paradigm, with 20% of target and 80% of non-target stimuli. The results analysis showed a significantly longer latency P300 and reduced amplitude P300 in subjects with subclinical hypothyroidism compared to euthyroid subjects. There is also a statistically significant negative correlation between the results of a mini mental state examination and the P300 latency at Fz electrode (r= -0.47, p <0.01) and Cz electrode (r= -0.43, p =0.017). P300 ERP is important in the evaluation of patients with subclinical hypothyroidism, due to the sensitivity in the detection cognitive disorders.

Event-related potential which represents a large positive wave which varies in amplitude and depends on subject's capability as well as on stimulus modality on which subject needs to react and appears around 300 ms after stimulation is called event related potential P300. In 1965. Sutton and the assistants were the first to suggest division of evocated potentials, according to the stimulus that provoke them, on "exogenous" (under the influence of exogenous stimulus) and "endogenous" or "cognitive" provoked by endogenous stimulus, which depends on the state of consciousness (vigilance), attention, concentration and especially, the type of the task a subject needs to perform during the recording. One of the most studied responses of the event-related potentials is so called "P300", the late positive wave complex which appears around 300 500ms after the stimulus. It is gained when the subjects' attention is focused on the signal which rarely appears, especially if the signal has some emotional or motivational meaning. The aim of this work was to determine whether there was a difference in latency and amplitude of the event related potential P300 when the button is pushed with dominant hand compared with nondominant hand in both males and females. The experiment included 30 subjects (15 males and 15 females). P300 potential was provoked with the auditive "oddball" paradigm. Event-related potencial P300 is recorded with 10-20 system. Cz electrode is set in the middle of nazion-inion line, while Fz electrode is set on the third of nazion-inion line above frontal lobe. In classical "oddball" paradigm, when a subject reacted on the signal by pushing the button with dominant hand, the value of Fz end Cz latency was significantly shorter in comparison to the values of Fz end Cz latency gained by pushing the button with non-dominant hand (left hand) in males, while such differences were not found in females. 

By the investigation it was attempted to explain the fear in adolescents from stomatological treatment, by appraisement of fear through its two components (congnitive and motorical). Congnitive component was followed by means of question mark before first stomatologican intervention (by the standard scale of general anxiety). In the research participated 100 adolescents. On the basis of analysis of question-marks, examinees were distributed into three groups: normal, pathological and increasingly anxious. On the occasion of third stomatological intervention, the patients obtained placebo (vitamine C, half tablet, orally, 30 minutes before the initiation of stomatological interventions which were identical, i.e. the sanation of deep caries has been carried out). The motorical component (entering the dentist's office, sitting down in a dentis chair and tonning of muscles) were appraised by the method of clinical observations. All parameters were measured before all three stomatological interventions. In this study, in parameters measured by clinical observation the number of questioned people who enter and sit down voluntarily, has increased and the number of people who are showing the signs of tension and who shiver has decreased, at using of placebo therapy.

Febrile seizures are the most common neurological disorder of early childhood. By expressing the characteristics febrile seizures are divided into simple and complex. Our aim was to determine the elektroencephalography characteristics in children who had febrile seizures, and determine the relation between types of febrile seizures correlates with the appearance of epilepsy in children aged 9-11 years. In the group of children studied, 50% had a complex febrile seizures, 42.2% had simple febrile seizures, and 7.8% children had febrile epileptic status. The analysis of EEG findings observed were statistically significant differences in specific changes in the EEG depending on the type of febrile attack that the child would have. In the group of children with simple febrile attacks 92.1% has a normal EEG, 2.6% had a specific, a 5.3% nonspecific finding. For children with complex febrile attack, 44.4% have a specific, and 13.3% of non-specific changes in EEG. Specific changes in the EEG has 28.6% of children who had febrile epileptic status.

Bronchial asthma is the syndrome, characterized with chronic inflammation, hyperreactivity and obstruction of the respiratory pathways, accompanied with consequential symptoms and remodeling of the respiratory pathways. Application of inhaled corticosteroids accompanied with appropriate education of patients, significantly improve therapeutic treatment and outcome of the asthma. But, improvement of the lung function and patients subjective state is remarkable better yif inhaled corticosteroids are combined with adrenergic â2 agonists, than if the dose of inhaled corticosteroids is increased. So, according to Global initiative for asthma and clinical results long acting adrenergic â2 agonists in combination with inhaled corticosteroids are most efficient in asthma treatment and establishment and conservation of bronchial asthma control. 

The aim of this study was registration of change in the amplitude of motor unit action potentials of m. bicepsa brachii of the dominant arm in fatigue. Investigation as coducted on 30 participants (15 male and 15 female). In the first phase of the research, 1-RM (one repetition maximum) of the dominant arm was measured. In the second phase, registration of changes in the amplitude of motor units action potentials was conducted during static contraction. Registration was performed twice, with time interval of 15 minutes. The second measurement was significantly shorter than the first. Analysis of EMNG-registration showed linear increase in MUAPamplitude in time. Significantly higher values of MUAPamplitude in the second measurements were registrated in both groups (p<0.05). Analysis of MUAPamlitude velocity change showed significantly higher values in the second measurement in males. There is no significant change in all registered values between males and females (p> 0.05).

Nowdays, reaction time is most often used in data processing as a quantitative method and technique for information step and speed processing. The aim of this investigation was to examine everyday work pressure on reaction time nd among students. An examination included 30 students of 2 year of Medicine Faculty 15 males and 15 females. Audible and visual simple reaction time as well as choice reaction time for 2, 4 and 6 stimuli was used for reaction time measurement. Measurements were done three times a day. Achieved results acknowledge statistically significant improvement of reaction time at noon compared to reaction time in the morning in all samples except for visual simple reaction time for male students. For all kinds of stimuli, reaction time were significantly prolonged in the evening in both groups. Therefore, we have concluded that morning activities had positive impact on students functional condition but afternoon activities acted like an additional stress that altered students latent fatigue to clearly observable acute fatigue.

Ginkgo biloba is the oldest tree on the planet. Its healing characteristics have been weel known for more than 3000 years. The aim of this investigation to establish the influence of Ginkgo biloba extract (Egb 761 Tanakan) on bioelectric activity of brain in humans. 30 subjects aged from 52 to 56 years were included in study. The bioelectric activity (EEG) was registrated before and after three month therapy with Ginkgo biloba extract. The obtained results showed that summary bioelectric activity speeds up. Frequency of alpha rhytms increases significantly, number of desinchrayitation desreases, decreases number of non specific activity 

As a result of long-term heroin abuse we can see impairment of cerebral structures, that leads to specific deficits in cognitive and conative area. There is a positive correlation between intensity of mentioned deficits and duration of heroin abuse. Attention is a cognitive function highly sensitive to toxic effects of opioids. Attention disorders and concentration disorders in opiate addicts are frequently described as a part of frontal syndrome, in consideration of high neurons sensitivity of frontal and prefrontal cortex to heroin. The aim of this study was to evaluate results of heroin addicts on Trail making test, in order to estimate the effect of heroin abuse on attention and specific relation between attention deficit with the duration of abuse. Ninty heroin addicts, divided in tree groups, regarding to abuse duration, were included in study. Results showed that heroin abuse longer than one year is connected with attention disorders, like low flexibility of attention and low selectivity of attention. The intensity of mentioned effects is higher in addicts who use higher daily dosage of heroin

Drugs prescription and drugs accessibility are among the most important drug use related topics. A patients questionnaire was conducted in the area of Novi Sad, Bačka Palanka, Bač, Temerin and Odžak (all in South Bačka region), because the routine medical statistics does not provide all neccessary data about the drugs availability. It is demonstrated that pressure and expectations of patients and doctor-patient relationship influence the choice of drugs to be prescribed. Positive list drugs deficiency represent a great problem, forcing patients to buy drugs in private-owned stores or abroad.