The thyroid gland produces two major active thyroid hormones, thyroxin (T4) and triiodothyronine (T3). The production of these hormones within the thyroid is regulated by thyreotropin (thyroid-stimulating-hormone- TSH). Iodine deficiency is the most common cause of goiter and borderline hypothireoidsm word-widw. In non iodine deficient areas, however autoimmunity is the most common cause of hypothyroidism. Destructive therapy by surgery or radioiodine for thyrotoxicosis acounts for approximately one third of all cases excessive iodine (e. g. as e result of chronic ingestion of proprietary cough medicines) may also cause hi pothyreoidsm. Primary hypothireoidsm due to failure much more common than failure secondary to pituitary dysfunction, or tertiary hypothireoidsm due to hypothalamic disease. The symptom of hypothireoidsm are non-specific and may be attributed by bath patient and doctor to ageing the onset usually being insidious. Hypothireoidsm is treated with replacement T4 therapy. The author describe a 55 year-old women with diagnosis of Primary hypothireoidism. The disease had a rarely course with disorders this metabolism lipids and complications here cardiovascular system. 

Sindrom X or Metabolic Syndrome are both terms used to describe a collection of herth risks contitions that increase your chance os developing heart disease, stroke and diabetes. The condition is aslo known by other names including insulin Resistence syndrome, and Dysmetabolic syndrome. The number of people with Metabolic Syndrome increases with
age, affecting more than 40 percent of people in their 60 s and 70 s. Components of Metabolic Syndrome are: Abdominal obesity, atherogenic dyslipidemia, raised blood pressure, insulin resistance, proinflamate state and prothrombotic state. The
National Cholesterol Education Program 's Adult Treatment Panel III report (ATPIII) identified 6 components of the metabolic syndrome that relevate to CVD. Insulin resistance is present in the majority of people with the matabolic syndrome.
It strongly associates is present with other metabolic risk factors and correlates unuvariately with CVD risk. Patiens with
longstanding insulin resistance frequently manifest glucose intolerance. When glucose intolerance evolves into diabetslevel hyperglicemia, independent risk factor for CVD. When 3 of 5 of the listed caracteristics are present, a diagnosis of metabolic syndrome can be made. The exact cause of Metabolic syndrome is not known. Most reserchers believe it is caused by
a combination of your genetic makeup and lifestyle choices-including the types of food you eat and level of physical activity.