Trombofilija, urođena ili stečena, tokom trudnoće, može dovesti do spontanog pobačaja, intrauterinog zastoja u rastu ploda koji može biti rani ili kasni, do preeklampsije i eklampsije kao i do prevremenog odlubljivanja posteljice. Tokom trudnoće, fiziološki se razvija hiperkoagulacija zbog normalnih promena u zgrušavanju krvi i fibrinolize. Ovakvo stanje u krvi trudnice ima potencijal da reaguje sa promenama u zgrušavanju krvi koje se javljaju kod trombofilije I potencijalno prouzrokovati neželjene komplikacije koje mogu ugroziti kako plod tako i trudnicu. Ispitivanja ka potencijalnoj trombofiliji, treba tražiti kod pacijantkinja kod kojih se ponavlja loš ishod trudnoće,intrauterini zastoj u rastu, fetalna smrt, preeklampsija.

The aim of work was to find out whether multiparity led to increased morbidity and mortality of mothers multyparous. Special attention was paid to appearance of diseases among mothers, both those developed during pregnancy and immediately after delivery. Multiparity is especially characteristic of women of Albanian nationality. Thus it is obvious that there is a reverse proportion between multiparous women and level of education the higher level of education is the smaller is the number of previous deliveries. There is a significant difference in apsolute number of deliveries according to the place of living in favor of rural residence. Number of both EPH gestoses (Eclampsia, pre-eclampsia) and indications for Caesarian section is increasing with multiparity. Abruption of normaly inserted placenta is significantly more frequent among multiparous women. It is obvious that multiparous women more frequently have bleedings during third and forth delivery period. There were also a large number of hysterectomies during delivery (75). Death rate of women is significantly increasing with multiparity. Eclampsia is the cause of death among more than half of all women. Resuming all data the autor is pointing out that grand multiparity, giving birth to more than six children, is, mfom medical point of view, an increased risk both for a newborn and a pregnant woman. Perinatal motality and morbidity is increased and high risk during pregnancy, delivery and puerperium is simultaneously rising until the pregnant woman's life is seriously endangered

Of 130 examined women who had not undergone a cytological and colposcopy check-up for at least a year, there were positive colposcopy: mosaic 39 (30,00 %), atipic vascularisation 15 (11,54 %) and suspect of invasive cervical cancer 1 (0,77 %). While the invasive carcinoma was ascertained most frequently at the ages of 40 to 59. The frequent incidence of severe displasia in subjects is 2,31 %, microinvasive cervical cancer 1,45 %, and the incidence of the invasive carcinoma is 3,85%.