The aim is to determine pathological -ulcero-erosive changes in the gastroduodenal mucosa (erosions, ulcers, ulcers, ulcer complications, subepithelial hemorrhage, etc.) resulting from the adverse effects of salicylates /ACK/ corticosteroid, imunoodulatora which was prescribed in the treatment of rheumatoid arthritis (RA). The test was performed on 50 patients diagnosed with RA who were on the two-year continuous therapy. When respondents were done gastroscopy and pathological macroscopic changes resulting from the gastroduodenal mucosa as a result of adverse effects of administered drugs verified. After two years of preparations ACK controlled therapy, corticosteroids, imunomodula- sector on mucosa gastroduodenal erosions were found in 81.5% of patients, gastric ulcer in 33%, duodenal ulcer with 18.5% of patients and bleeding in 44.4%.

Cilj rada je da utvrdi patoloske promene na sluznici gastroduodenuma (erozije,ulceracije, ulkusi, komplikacije ulkusa,subepitelna krvarenja i dr) nastale kao posledica stetnog dejstva NSAIL (Nesteroidnih antireumatika )lekova koji su ordinirani u terapiji Reumatoidnog artrit-(RA). Ispitivanje je vrseno na 100 bolesnika sa dijagnostikovanim RA koji su bili na kontinuiranoj terapiji NSAIL. Kod polovine bolesnika uradjena je gastroskopija da bi se verifikovale patoloske makromorfoloske promene pre kontrolisanog uzimanja NSAIL Posle 2godine uzimanja kontinuirane terapije NSAIL uradjena je kontrolna gastroskopija a patoloske makromorfoloske-endoskopske promene verifikovale. Posle dvogodisnje kontrolisane terapije NSAIL na sluznici gastroduodenuma erozije su opisane u 66% bolesnika, ulkus zeluca u 18%, duodenalni ulkus kod 14% bolesnika, krvarenja u 25% bolesnika.

Degenerative diseases are no inflammatory diseases intervertebrales discus, joints and ligaments vertebrae with subsequent changes in the bony spine structures. Degenerative diseases are very common and lumbar syndrome is most of them common. Because large disability that gives not only a medical but also social and economic problem. Starting of these facts here, work is set purpose,to the overall context of the diagnosis,differential diagnosis of degenerative lumbar sindrom. This is a complex problem that requires a great effort, expertise and modern diagnostic procedures in clinical rheumatology, which is outstanding problem in practice. We hove processed 55 patients with chronic low back pain and 20 patients with chronic low back pain and other etiology. With history, clinical examination, laboratory analysis, Rtg recordings,and other additional analysis (EMG,CT,MRI) that dodge tried to make the diagnosis and successful treatment.