The research was conducted at the Department of Pathology and Histology of Clinical center of Novi Sad. We analysed the reports of autopsies of newborns (to 28 days old), stillborns and miscarried fetuses in 1991 and 2001. Found
malformations were classified according to organ systems. Results for 1991 show next structure of congenital malformations: 3 malformations of central nervous system (14.29%), 0 malformations of urogenital system (0%), 3 malformations of
gastrointestinal system (14.29%), 1 malformations of musculosceletal system (4.76%), 9 malformations of cardiovascular
system (42.86%), 1 chromosomal defects (4.76%), 4 multiple malformations (19.05%). Results for 2001 have next value: 9
malformations of central nervous system (27.27%), 4 malformations of urogenital system (12.12%), 5 malformations of
gastrointestinal system (15.15%), 0 malformations of musculosceletal system (0%), 4 malformations of cardiovascular
system (12.12%), 2 chromosomal defects (6.06%), 9 multiple malformations (27.27%). By the comperison of the results of
structure of congenital malformations in 1991 and 2001, we can conclude that the differences of cardiovascular and urogenital malformations are statistically important