The tests were made at deparment of infertility at the Gynecology and Obstretics Institute of Clinical Center of Serbia in the period from 01.01. untill 31.12.1998. The three hundred patients, on which hysterosalpingography (HSG) was made, and patients, on which chromolaparoscopy was made, were involved by prospectus studies. In the laparoscopy the larger anomalies of the uterus and significant hypoplasy coincide with HSG finding, while hypoplasy in the lower level or uterus arcuatus always can not be established by laparoscopy.The higher frequency of all pathological alterations of the uterus, except the myoma of the uterus, was established by HSG, relating to laparoscopy. Associate pathological alterations were established in the higher percent by HSG than by the laparoscopy, while the single changes were diagnosed in the lower percent.The deficit in the loading of the uterus by the constrast medium, also the changes at the endometrium, could be proved by HSG only. Intravasation can be identified by the both methods. In the diagnosis of the myoma of the uterus, laparoscopy is more important method than HSG.Pathological alterations of the uterus, especially higher anomalies of the uterus and hypoplasy were established in the higher percent by HSG than by the laparoscopy, but statistically the more significant difference was not established in the application of the both methods

Ahigher concentrations of microorganisms in the vagina can lead to preterm delivery. Bacterial vaginosis is a well known risk factor of preterm delivery. Aim of this study was to estimate the presence of bacterial vaginosis as a potential cause of preterm delivery relative to the patients with term delivery, as well as to define the type of present bacteria. The results of our investigation showed more frequent presence of bacterial infection of the vagina in the patients with preterm delivery. The following bacteria have been cultured in the group of patients with preterm delivery: Streptocossus agalctiae, Enterococcus, Staphylococcus sp. and Escherichia coli. In prevention of preterm delivery, we recommend a routine screening of pregnant women (such as obtaining smears to bacterial infection) as well as administration of the therapy in case of positive findings, particularly in those presenting a risk for the development of bacterial vaginosis and preterm delivery. 

The genes mutate either spontaneously or under the influence of mutagenic agents (irradiation, viruses, toxins).
The occurrence of genetic syndromes in the scope of one family is pointing more to the inherited than to de novo mutation.
Aim of this study was to present two syndromes in the same family tree, occurring subsequently one by one, which carry severe mental retardation and have a poor prognosis and frequently tragic outcome. A case report was given of a patient in
whom both pregnancies were completed by birth of the newborns presenting with severe syndromes: the first one with
Down's syndrome and the second one with Prader-Willi-Labhart syndrome. The results of investigation point to the necessity of genetic investigations before pregnancy and during pregnancy as early as possible, in order to avoid giving birth to
the children with syndromes which bear severe mental retardation and having poor prognosis.